Chemical Name:	4-Butylbenzene-1,3-diol
CAS Number:	18979-61-8
Specification:	99%+ (HPLC)
Test Method:	HPLC-UV, GC-MS
Packaging:	Double-layer poly bags inside, sealed foil-lined paper-drums. Net weight: 1kg, 5kg, 25kg/drum
Main Benefits:	Potent tyrosinase inhibition, even skin tone, reduces hyperpigmentation
Application:	Cosmetics, topical skincare (creams, serums, lotions)

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity Control

   • HPLC-UV/GC-MS Dual Verification: Purity is stringently controlled to ≥99.0% (tested per in-house and pharmacopoeia standards). Impurity profile monitored down to 0.05%.

   • Heavy Metal Screening: ICP-MS analysis confirms conformity with global cosmetic regulations: Lead (Pb) < 2 ppm, Arsenic (As) < 1 ppm, Mercury (Hg) < 0.1 ppm, Cadmium (Cd) < 0.1 ppm.

   • Residual Solvents: GC-FID analysis verifies absence of residual solvents like ethyl acetate or heptane, complying with ICH Q3C guidelines for topical applications.

2. Advanced Synthesis & Purification Technology

   • Optimized Synthesis Route: Proprietary, multi-step organic synthesis (Patent Pending) using high-purity precursors to minimize side reactions and by-product formation (e.g., resorcinol isomers).

   • Controlled Crystallization Process: High-vacuum distillation followed by low-temperature, multi-solvent recrystallization yields a consistently pure, white to off-white crystalline powder with a sharp melting point.

   • Eco-Impact: Our closed-loop solvent recovery system reduces VOC emissions and solvent waste by over 85% compared to conventional batch processes, supporting your green formulation goals.

3. Stability & Shelf-Life Superiority

   • Accelerated Stability Data: Formulated in a standard oil-in-water emulsion and tested under ICH conditions, it retains ≥98% potency after 24 months at 25°C/60% RH and 6 months at 40°C/75% RH.

   • Thermal & Oxidative Protection: Supplied in nitrogen-flushed, light-protective, vacuum-sealed foil packaging to prevent oxidation and discoloration, ensuring formulation-ready integrity.

Scientific Evidence: Mechanism & Efficacy

1. Potent Tyrosinase Inhibition

   • Direct Enzyme Targeting: Acts as a competitive inhibitor of tyrosinase, the rate-limiting enzyme in melanogenesis. Binds directly to the enzyme’s active site, blocking the conversion of L-tyrosine to L-DOPA and L-DOPA to dopaquinone.

   • Comparative Potency Data: In vitro studies demonstrate an IC50 value of 5 µM for tyrosinase inhibition, showing significantly higher potency than kojic acid (IC50 ~25 µM) and hydroquinone under the same assay conditions.

2. Visible Reduction in Hyperpigmentation

   • Clinical Outcomes (Human Patch Test): In a 8-week, double-blind, placebo-controlled study (n=30 with facial melasma):

     • 42% reduction in melanin index (measured by Mexameter) with 1% 4-Butylresorcinol cream.

     • 31% improvement in skin tone evenness (clinical grading per standardized scale).

     • Visible lightening of age spots and post-inflammatory marks was observed as early as week 4.

3. Superior Efficacy & Safety Profile

   • Favorable Safety Margin: Unlike hydroquinone, 4-Butylresorcinol is not genotoxic and shows no evidence of exogenous ochronosis in long-term dermal studies.

   • Non-Irritating at Effective Levels: Formulated at 0.1-1.0%, it demonstrates excellent skin compatibility with no significant irritation in HRIPT (Human Repeat Insult Patch Test) at recommended use levels.

Formulation-Ready Advantages

Application-Specific Benefits:

• Serums & Light Lotions: Pre-dissolve in a small amount of propylene glycol, ethoxydiglycol, or a suitable oil phase at 40-50°C for homogeneous dispersion. Compatible with standard thickeners like xanthan gum and carbomer.

• Creams & Emulsions: Easily incorporated into the heated oil phase during emulsification. Maintains stability in pH range 4.0-7.0.

• Leave-on & Rinse-off Products: Effective and stable in both leave-on creams (0.5-1.0%) and rinse-off cleansers (0.1-0.5%).

• Synergistic Blends: Pairs effectively with niacinamide, vitamin C (ascorbic acid), and alpha-hydroxy acids (AHAs) for enhanced brightening and exfoliation.

Supply Chain & Compliance Leadership

1. Audited Transparency

   • Full Traceability: Certificate of Analysis (COA) includes detailed impurity profile, residual solvent data, and heavy metal analysis.

   • Batch Consistency: All production across our ISO 22716 (GMP for cosmetics) certified facilities ensures batch-to-batch uniformity.

2. Regulatory Preparedness

   • Global Dossiers: We provide comprehensive Technical Data Sheets (TDS), Material Safety Data Sheets (MSDS), Allergen Statements, and GMP compliance documents to support your international registrations.

   • Cosmetic Compliance: Full documentation available to support safety assessments under EU Cosmetic Regulation (EC) No 1223/2009, and compliance with FDA guidelines for OTC cosmetic ingredients.

3. Ethical & Safety Certifications

   • Cruelty-Free & Vegan: No animal testing conducted; product suitable for vegan formulations.

   • Allergen-Free: Validated free from the 26 major declared fragrance allergens (EU CosIng).

Competitive Breakdown: SRBio vs. Market Alternatives

Common Deficiencies in Standard 4-Butylresorcinol:

• Resorcinol Contamination: Presence of unreacted resorcinol, a known skin irritant, can cause formulation instability and adverse reactions.

• Discoloration Issues: Lower purity grades often contain colored oxidation products, leading to yellowing or browning of final cosmetic creams and serums.

• Inconsistent Potency: Variable purity and impurity profiles lead to unpredictable efficacy and formulation behavior.

SRBio’s High-Purity Advantage:

• <0.1% Free Resorcinol: Our advanced purification ensures virtually undetectable levels of free resorcinol, maximizing safety and minimizing irritation potential.

• Superior Color Stability: High purity and antioxidant packaging guarantee a pristine white powder that remains color-stable in formulations, protecting the aesthetic integrity of your products.

• Predictable Performance: Consistent purity (≥99.0%) ensures reliable tyrosinase inhibition and predictable solubility in every batch.

Technical Partnership Program for Cosmetic Brands

1. Co-Development Services

   • Formulation Stability Testing: ICH-compliant stability studies for your specific prototype (e.g., vitamin C + 4-butylresorcinol serum). We assess compatibility, potency retention, and color change over time.

   • Efficacy Validation: Access to in vitro tyrosinase inhibition assays or ex-vivo skin permeation studies (Franz cell) to support your product claims.

2. Market-Ready Solutions

   • Custom Pre-Blends:

     • BrightSynergy™: 4-Butylresorcinol + Niacinamide + Enantia Chlorantha Bark Extract (targets multiple melanin pathways).

     • EvenTone Complex®: 4-Butylresorcinol + Microencapsulated Retinol (for brightening with reduced retinoid irritation).

   • Turnkey Sampling: Receive 50g/100g trial samples with full COA and MSDS for R&D validation, typically shipped within 48-72 hours.

Shipping & Packing Information

OEM SERVICE

We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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