Chemical Name:	(R)-3-Acetyloxy-4-(trimethylazaniumyl)butanoate
CAS Number:	14992-62-2
Molecular Formula:	C₉H₁₇NO₄
Molecular Weight:	203.24 g/mol
Specification:	99%+ (HPLC)
Test Method:	HPLC-UV, Titration
Packaging:	Double-layer poly bags inside, sealed foil-lined paper-drums. Net weight: 1kg, 5kg, 25kg/drum
Main Benefits:	Supports mitochondrial energy production, crosses blood-brain barrier, provides neuroprotective antioxidant effects
Application:	Dietary supplements, cognitive health formulas, sports nutrition

Fuel Mind and Body with Premium Acetyl-L-Carnitine (ALCAR) by SRBio

SRBio Acetyl-L-Carnitine (ALCAR) is the acetylated ester of L-carnitine, a naturally occurring amino acid derivative crucial for cellular energy metabolism. Unlike standard L-carnitine, the acetyl group allows ALCAR to cross the blood-brain barrier, making it uniquely effective for both peripheral energy support and cognitive function. Sourced and manufactured under strict GMP guidelines, SRBio offers high-purity ALCAR powder designed for optimal bioavailability, stability, and formulation flexibility in premium dietary supplements.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity Control

   • HPLC-UV/Titration Dual Verification: Purity is stringently controlled to ≥99.0% (HPLC). Chiral purity (L-isomer) is verified to be >99.5%, ensuring maximum biological activity and absence of the inactive D-form.

   • Heavy Metal Screening: ICP-MS analysis confirms conformity with global pharmacopoeia standards (USP, EP): Lead (Pb) < 1 ppm, Arsenic (As) < 0.5 ppm, Cadmium (Cd) < 0.1 ppm, Mercury (Hg) < 0.1 ppm.

   • Residual Solvents: GC-FID analysis verifies compliance with ICH Q3C guidelines, with all Class 1 and Class 2 solvents below detectable limits. Residual acetone and ethanol (from synthesis) are controlled to <100 ppm.

2. Advanced Synthesis & Purification Technology

   • Enantiomerically Pure Synthesis: Proprietary synthesis route starts from high-purity L-carnitine, followed by a selective enzymatic or chemical acetylation process that preserves the chiral integrity of the molecule.

   • Multi-Step Purification Process:

     1. Ion Exchange Chromatography: Removes ionic impurities and unreacted L-carnitine.

     2. Activated Carbon Treatment: Eliminates color bodies and pyrogenic substances.

     3. Controlled Crystallization: Low-temperature crystallization from food-grade solvents yields a brilliant white, crystalline powder with consistent particle size and excellent flow properties.

   • Eco-Impact: Solvent recovery systems achieve >90% recycling rates, minimizing environmental footprint and ensuring sustainable production.

3. Stability & Shelf-Life Superiority

   • Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH and 12 months at 40°C/75% RH in sealed, moisture-protected packaging (ICH Q1A tested).

   • Hygroscopicity Control: Engineered particle morphology and nitrogen-flushed, foil-laminated packaging minimize moisture absorption, preventing caking and ensuring free-flowing powder characteristics.

Scientific Evidence: Mechanism & Efficacy

1. Dual-Action Mitochondrial Support

   • Fatty Acid Oxidation: Transports activated long-chain fatty acids (acyl groups) across the inner mitochondrial membrane for β-oxidation, fueling cellular ATP production in muscles and peripheral tissues.

   • Acetyl Group Donation: The acetyl moiety contributes to the acetyl-CoA pool in mitochondria, supporting the Krebs cycle and enhancing energy yield, particularly under high metabolic demand.

2. Neurocognitive Benefits

   • Blood-Brain Barrier Penetration: The acetyl group facilitates passive diffusion across the blood-brain barrier, delivering carnitine directly to neurons.

   • Neurotransmitter Modulation: Serves as a precursor for acetylcholine synthesis and modulates cholinergic neurotransmission, which is vital for memory and learning.

   • Clinical Outcomes (Meta-Analysis Review): A meta-analysis of double-blind, placebo-controlled trials (e.g., in Journal of Alzheimer’s Disease) indicates that ALCAR supplementation (1.5-3.0 g/day) can slow cognitive decline and improve clinical scales in patients with mild cognitive impairment and early-stage Alzheimer’s disease.

3. Antioxidant & Neuroprotective Effects

   • Membrane Stabilization: Protects neuronal membranes from peroxidation by chelating iron and copper ions, reducing free radical damage.

   • Mitochondrial Protection in Aging: Shown to restore age-related declines in mitochondrial membrane potential and cardiolipin levels in brain tissue, preserving neuronal energy homeostasis.

   • Nerve Growth Factor (NGF) Support: In vitro studies suggest ALCAR can support NGF signaling, promoting neuronal survival and repair.

Formulation-Ready Advantages

Application-Specific Benefits:

• Cognitive Health Capsules/Tablets: Excellent flowability and compressibility for high-speed tableting. Compatible with common excipients (microcrystalline cellulose, magnesium stearate).

• Sports Nutrition Powders: Neutral taste profile when blended; mixes readily in water or beverages without significant sedimentation. Compatible with electrolytes and BCAAs.

• Anti-Aging & Neuroprotective Formulas: Ideal pairing with other cognitive ingredients like Phosphatidylserine, Ginkgo Biloba, or PQQ for synergistic mitochondrial and brain health formulations.

• Liquid & RTD Formulations: Stable in aqueous solutions within a pH range of 3.0-6.0. Preservative efficacy testing available for custom liquid prototypes.

Supply Chain & Compliance Leadership

1. Audited Transparency

   • Full Traceability: Certificate of Analysis (COA) includes detailed impurity profile, residual solvent data, heavy metal analysis, and microbiological specifications (TPC, Yeast & Mold, E. coli, Salmonella).

   • Batch Consistency: All production across our ISO 9001 (Quality Management) and GMP-certified facilities ensures batch-to-batch uniformity for global customers.

2. Regulatory Preparedness

   • Global Dossiers: We provide comprehensive Technical Data Sheets (TDS), Material Safety Data Sheets (MSDS), Allergen Statements, and Kosher/Halal certifications upon request.

   • Supplement Compliance: Full documentation available to support dietary supplement registrations under FDA DSHEA guidelines, EU Food Supplements Directive, and other international frameworks.

3. Ethical & Safety Certifications

   • Vegan Society Verified: Production process uses no animal-derived inputs. Suitable for vegan and vegetarian formulations.

   • Allergen-Free: Validated free from gluten, soy, dairy, egg, peanuts, and crustaceans (ELISA tested).

   • Non-GMO & BSE/TSE Free: Certified free from GMO materials and Transmissible Spongiform Encephalopathy risks.

Competitive Breakdown: SRBio vs. Market Alternatives

Common Deficiencies in Standard Acetyl-L-Carnitine:

• Residual L-Carnitine: Incomplete acetylation can leave significant residual L-carnitine, reducing the specific cognitive benefits associated with ALCAR.

• Hydrolysis & Odor: Exposure to moisture can hydrolyze ALCAR back to L-carnitine and acetic acid, potentially causing a vinegar-like odor in the final product.

• Chiral Impurities: Racemization during synthesis can produce the biologically inactive D-isomer, reducing overall efficacy.

• Poor Flow Properties: Standard material can be cohesive or sticky, causing issues in high-speed capsule filling or tablet compression.

SRBio’s High-Purity Advantage:

• Minimal Residual L-Carnitine (<0.5%): Our optimized acetylation and purification process ensures maximum conversion, guaranteeing the potency of the acetylated form.

• Superior Stability & Odor Control: Advanced drying and packaging technologies prevent hydrolysis, ensuring a stable, odorless product throughout its shelf life.

• Chirally Pure (>99.5% L-Form): Guaranteed enantiomeric purity ensures you deliver the full, intended biological activity to your customers.

• Engineered Flowability: Consistent particle size distribution (D50 ~150-250 μm) ensures smooth, high-speed manufacturing with minimal waste.

Technical Partnership Program for Brands

1. Co-Development Services

   • Formulation Stability Testing: ICH-compliant stability studies for your specific finished product (e.g., ALCAR + Alpha-Lipoic Acid capsules). We assess potency retention and degradation products over time.

   • Custom Particle Engineering: Micronization or granulation services to meet specific requirements for blends, stick packs, or controlled-release formulations.

2. Market-Ready Solutions

   • Custom Pre-Blends:

     • Neuro-Energy™ Matrix: ALCAR + CoQ10 + B-Complex Vitamins (for comprehensive cellular and cognitive energy).

     • Mitochondrial Renew™: ALCAR + Alpha-Lipoic Acid + PQQ (targeted support for mitochondrial biogenesis and function).

   • Turnkey Sampling: Receive 1kg/5kg trial samples with full COA and MSDS for R&D and stability validation, typically shipped within 48-72 hours.

Video & Articles

Shipping & Packing Information

OEM SERVICE

We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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