SRBio Co-Crystallized Lutein: 20X Bioavailability, Unmatched Stability
BREAKTHROUGH TECHNOLOGY
1. Patented Co-Crystallization
-
Solvent-Free Mechanochemistry: Dry fusion with GRAS carriers (α-cyclodextrin, HPMC)
-
Supramolecular Architecture:
-
Hydrogen-bonded lattice (PXRD-validated) locks lutein against oxidation
-
36-month stability at 40°C/75% RH (ICH Q1A)
-
-
Bio-Performance:
Parameter SRBio Co-Crystal Standard Lutein Relative Bioavailability 20X (primate) 1X (baseline) Serum Cmax (μg/mL) 18.3 ± 2.1 0.9 ± 0.3 *Source: 6-month primate study (Mol. Nutr. Food Res. 2024)*
QUALITY & COMPLIANCE
Triple-Phase QC Protocol
-
Raw Material: Marigold extract ≥80% lutein (HPLC, USP <2027>)
-
In-Process: Crystallinity ≥97% (PXRD), moisture ≤1.5% (Karl Fischer)
-
Finished Product:
-
Dissolution ≥98% in 15 min (USP <711>, simulated gastric fluid)
-
Contaminants: Lead (<0.05 ppm), Total Aerobes (<1,000 CFU/g)
-
Global Certifications:
-
Regulatory: FDA GRAS Notice 1221, EFSA Novel Food 2024/2087, FSANZ
-
Purity: ISO 22000, Halal (JAKIM), Kosher (Star-K), Non-GMO (ProTerra)
-
Eco: CarbonNeutral® (scope 3 certified), USDA Organic
TECHNICAL SPECIFICATIONS
| Parameter | Specification | Method |
|---|---|---|
| Form | Free-flowing orange powder | Visual |
| Lutein Content | 20% ± 0.5 (w/w) | HPLC (ISO 20635) |
| Particle Size | D<sub>50</sub>: 10μm (D<sub>90</sub>≤25μm) | ISO 13320 |
| Solubility (25°C) | Water: ≥40 mg/mL | USP <1231> |
| ORAC Value | 950,000 μmol TE/g | Brunswick Labs |
APPLICATION ENGINEERING
Nutraceuticals
-
Softgels: 5mg dose = 100mg standard lutein efficacy (AREDS-2 equivalent)
-
Gummies: Zero crystallization at 3% loading (pH 4.0-5.5)
-
Tablets: Direct compression compatible (≤0.3% magnesium stearate)
Functional Foods
-
Beverages: Stable in clear drinks (0.05% w/v, pH 3.0-7.0; ∆E<2 @ 12mo)
-
Dairy: Homogeneous dispersion in yogurt (0.1% w/w; no syneresis)
Cosmeceuticals
-
Topical Efficacy:
-
2.8X faster dermal absorption vs. nanoemulsions (Franz cell)
-
Reduces blue light-induced ROS by 74% (in vitro, 0.5% dose)
-
SUPPLY CHAIN ADVANTAGES
-
Capacity: 8,000 kg/month | Lead Time: 12 days (standard)
-
Traceability:
-
Blockchain QR codes: Farm GPS + crystallization parameters + CoA
-
-
Packaging:
-
Nitrogen-flushed foil bags (1kg/5kg/25kg)
-
IBC totes (500kg) with humidity sensors
-
CUSTOMIZATION
-
Concentrations: 10%, 20%, 30% lutein (±0.5%)
-
Carrier Systems:
-
γ-Cyclodextrin (beverages), PVP K30 (tablets), Pullulan (organic)
-
-
Private Label:
-
MOQ 200kg | Turnkey solution: Formulation + regulatory dossier
-
PARTNER PROGRAM
1. Technical Enablement
-
Free formulation troubleshooting (48h response)
-
Joint clinical trial design (3 pending human studies)
2. Sampling & Trials
-
R&D Kit: 100g sample + Stability Report + 5 Application Guides
-
Pilot Batch: 100kg @ 30% discount (GMP-compliant)
CLINICAL & MARKET VALIDATION
*”SRBio’s co-crystals solved our gummy crystallization issues and increased product shelf life by 18 months. Their bioavailability data boosted our brand’s clinical credibility.”*
— Dr. Emma Chen, Chief Formulator, UK
Results: 42% sales growth in 6 months | 0 customer complaints
Video & Articles
Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
