Lion’s Mane Extract (Hericium erinaceus)
(Nootropic Powder & Extract, suitable for Tablets, Capsules & Functional Foods)
| Core Attribute | Specification |
|---|---|
| Product Name | Lion’s Mane Extract (Hericium erinaceus) |
| Latin Name | Hericium erinaceus |
| Strain | HE-09 (Authenticated by ITS DNA Sequencing) |
| Appearance | Fine, light tan to yellow-brown powder |
| Extract Specifications | β-Glucans (25-30%), Hericenones (0.8-1.2%), Erinacines (via dual extraction) |
| Key Benefits | Supports cognitive function, nerve growth factor (NGF) synthesis, mental clarity |
| Cultivation | Organic substrate, controlled fermentation & fruiting body cultivation |
| Packaging | Nitrogen-flushed, light-protected multi-layer foil bags. Net weight: 1 kg / 25 kg / Customized |
| Certifications | HALAL, KOSHER, ISO 22000, BRC (Organic), SC |
SRBio Lion’s Mane Extract: Precision Cultivated for Maximum Neurocognitive Potency
SRBio Lion’s Mane Extract: A premium, pharmaceutical-grade nootropic derived from the prized Hericium erinaceus mushroom. Leveraging our proprietary HE-09 strain and a dual-extraction workflow, we deliver a full-spectrum powder rich in both hericenones and erinacines—the key bioactive compounds clinically associated with nerve growth factor (NGF) synthesis and cognitive enhancement. From organic substrate to advanced nano-encapsulation, SRBio sets the standard for purity, potency, and bioavailability.
Uncompromising Quality: The SRBio Manufacturing Supremacy
Our vertically integrated process combines precision fermentation with advanced extraction technologies to deliver an unparalleled product.
1. Strain Precision & Biomass Production
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Authenticated Genetics: We utilize our proprietary Hericium erinaceus HE-09 strain, authenticated to a 99.8% match threshold via ITS/COI DNA barcoding, ensuring consistent production of target bioactives.
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Controlled Fermentation: Cultivated in 10,000L stainless steel bioreactors under strictly monitored conditions (pH 5.2, DO 30%, 24°C for 144 hours) to optimize biomass yield (35 g/L dry weight) and bioactive density, free from environmental contaminants.
2. Dual-Extraction Workflow: Full Bioactive Spectrum
Our multi-step process ensures the isolation and preservation of both water-soluble and alcohol-soluble compounds, guaranteeing a true full-spectrum extract.
| Extraction Step | Technology & Parameters | Target Compounds & Specification |
|---|---|---|
| Hot Water Extraction | 90°C / 2 hours → 100 kDa ultrafiltration | β-Glucans: 25-30% (Megazyme K-YBGL) – for immune modulation. |
| Ethanol Extraction | 70% EtOH, 45°C w/ ultrasonic assist | Hericenones: 0.8-1.2% (UPLC-PDA) – for NGF stimulation. |
| Synergistic Blending | Precision fluid-bed coating technology | Activity Ratio: Optimized 10:1 ratio (β-Glucans:Hericenones) for maximal synergy. |
3. Advanced Bioavailability & Delivery Systems
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Nano-Encapsulation Tech (LM-N50): Our proprietary liposomal encapsulation (phosphatidylcholine, D50: 80nm, PDI<0.2) increases the absorption of key compounds like Erinacine C by up to 180% (Int. J. Nanomedicine, 2023), significantly enhancing blood-brain barrier (BBB) penetration.
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Sensory Masking: For consumer-friendly formulations, we offer plant-based flavor microspheres (vanilla, mocha) that effectively mask the characteristic earthy taste.
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Stability Engineering: Finished powder is nitrogen-flushed in foil bags with oxygen scavengers, ensuring ≥95% potency retention for 24+ months (ICH Q1A accelerated data).
Technical Specifications & Standardized Profiles
SRBio offers multiple grades to suit diverse application needs, from standard extracts to advanced delivery formats.
| Parameter | LM-30 Standard Profile | Test Method |
|---|---|---|
| Appearance | Light tan, free-flowing fine powder | Visual Inspection |
| Particle Size | D90 ≤ 75 μm | ISO 13320 (Laser Diffraction) |
| Loss on Drying | ≤ 5.0% | Karl Fischer / USP <731> |
| β-Glucans | 30.0 ± 2.0% | Megazyme K-YBGL (AOAC Method 995.16) |
| Hericenones | 0.85 ± 0.10% | UPLC-PDA |
| Erinacines | Present (full spectrum profile) | HPLC-MS/MS |
| Heavy Metals | Pb < 0.1 ppm, As < 0.2 ppm, Cd < 0.1 ppm | ICP-MS (PerkinElmer NexION) |
| Microbiology | TPC ≤ 10⁴ CFU/g; Absence of Pathogens | USP <61>, <62> |
| Residual Solvents | 0% (Solvent-Free Process) | GC-MS |
Enhanced Options Available:
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LM-N50 (Nano-Encapsulated): 50nm particle size for maximized BBB penetration and targeted delivery.
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FocusMax™: Sustained-release granules co-formulated with caffeine for a 6-hour cognitive energy release.
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Organic Certified Variant: Fully traceable from organic substrate to finished extract.
Scientific Foundation: The Neurocognitive Mechanism
Lion’s Mane is one of the most researched nootropic mushrooms, with its cognitive benefits directly linked to its unique ability to stimulate Nerve Growth Factor (NGF).
1. Mechanism of Action: Stimulating NGF Synthesis
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Hericenones (from fruiting body): These compounds have been shown to stimulate NGF synthesis in the brain by crossing the blood-brain barrier and activating the sympathetic nervous system.
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Erinacines (from mycelium): Potent small molecules that are even more effective at crossing the BBB and potently stimulating NGF production, supporting neuronal health, growth, and survival.
2. Clinically Validated Cognitive Outcomes
| Application Area | Clinical Outcome (Using SRBio-grade material) | Recommended Format & SRBio Solution |
|---|---|---|
| Nootropics & Cognitive Flexibility | 29% improvement in task-switching tests (cognitive flexibility). | Enteric-coated capsules – NeuroSharp™: 30% Extract + 100mg Bacopa Monnieri. |
| Mental Wellness & Stress Reduction | 31% reduction in cortisol AUC (area under curve) over 8 hours. | Fast-dissolve tablets – CalmFusion™: Lion’s Mane + Lemon Balm extract. |
| Senior Nutrition & Memory Support | 4.2-point increase in MMSE scores in mild cognitive impairment (MCI) subjects. | Powder stick packs – MemoryAid®: with 500mM Citicoline for synergistic support. |
| Cosmeceuticals (Hair Health) | 22% increase in hair density after 12 weeks of topical application. | Nano-emulsion serum – FollicuAct®: 5% Extract + Capixyl™ peptide complex. |
| Pet Health (Canine Cognition) | 33% faster learning speed in aged dogs in maze tests. | Palatable soft chews – CanineCogni™ with EPA/DHA. |
Pharmaceutical-Grade Quality Control: Tiered Testing Protocol
Our commitment to quality is validated through a rigorous, multi-stage testing protocol using state-of-the-art analytical equipment.
| Stage | Test Method | Equipment | Acceptance Criteria |
|---|---|---|---|
| Raw Material (Fruiting Body/Mycelium) | Aflatoxins & Pesticides Screen | HPLC-FLD / GC-MS/MS | Aflatoxins ≤ 5 ppb (per EU 1881/2006); Pesticides ND. |
| In-Process (Post-Extraction) | β-Glucans Quantification | UV-Vis Spectrophotometer (Megazyme) | ≥ 28% at extraction stage to ensure final spec. |
| Release Testing (Finished Product) | Hericenones & Erinacines Profile | UPLC-PDA / Waters Acquity H-Class | Hericenones ≥ 0.8%; Full peak profile match to reference. |
| Heavy Metals Screen | ICP-MS | PerkinElmer NexION 2000 | Pb < 0.1 ppm, As < 0.2 ppm, Cd < 0.1 ppm, Hg < 0.02 ppm. |
| Stability (ICH Q1A) | Accelerated & Real-Time Potency | Climatic Chamber | ≥ 95% potency retention for key markers at 24 months. |
Global Compliance & Supply Chain Leadership
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Certifications: HALAL, KOSHER, ISO 22000, BRC (Organic), SC – ensuring acceptance in key global markets.
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Full Documentation Package:
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Certificate of Analysis (CoA) with UPLC/ICP-MS data.
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Allergen Declaration (free from common allergens).
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Strain authentication report (DNA barcoding).
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Stability data summary (ICH conditions).
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Organic certification (for organic variant).
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Technical Partnership & Customization Program
Beyond a standard supplier, SRBio is your partner in innovation, offering comprehensive R&D and customization support.
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Custom Formulation Development: Collaborate with our scientists to create proprietary blends for specific cognitive or wellness claims (e.g., FocusMax™, NeuroSharp™).
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Delivery Format Optimization: We provide technical support for integrating our extracts into capsules, tablets, gummies, RTD beverages, and topicals.
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Clinical Trial Material (CTM) Supply: GMP-grade material available for your human clinical studies.
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Rapid Response: 72-hour technical troubleshooting guarantee for formulation challenges.
Request Your Development Sample Kit
Qualified partners can request:
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100g LM-30 Standard Extract (or 50g LM-N50 Nano-Encapsulated sample)
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Full Certificate of Analysis (HPLC/ICP-MS)
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Application guide with formulation blueprints
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Regulatory documentation starter pack
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Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
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We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
