Chemical Name	Trimagnesium Dicitrate Nonahydrate
CAS Number	153531-96-5
Molecular Formula	C₁₂H₂₈Mg₃O₂₃ / Mg₃(C₆H₅O₇)₂·9H₂O
EINECS Number	222-093-9
Specification	14.0% – 15.5% (Elemental Magnesium, on as-is basis)
Test Method	Complexometric Titration (EDTA) for Mg; HPLC for Citrate; Loss on Drying
Packaging	In paper-drums with double polyethylene bags inside. Net weight: 25kg/drum
Main Benefits	High-purity magnesium source, controlled solubility, ideal for solid dosage forms, supports bone and muscle health
Application	Dietary supplements, pharmaceuticals, food fortification, infant formula, clinical nutrition, feed & pet food

The Crystalline Choice for Controlled Release: Premium Magnesium Citrate Nonahydrate by SRBio

SRBio Magnesium Citrate Nonahydrate is a high-purity, crystalline magnesium salt produced from the reaction of citric acid and magnesium carbonate. Characterized by its nine molecules of hydration, this form offers a unique set of physical properties, including controlled solubility and excellent stability in solid formulations. It is widely recognized as a safe and effective source of magnesium for pharmaceutical, nutraceutical, and food applications where precise mineral delivery is required.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity & Composition Control

   • Guaranteed Elemental Magnesium: Our controlled crystallization process ensures a consistent elemental magnesium content between 14.0% and 15.5% (on an “as-is” basis), verified by complexometric titration.

   • Controlled Hydration: Rigorous process control ensures the consistent formation of the nonahydrate crystal structure (9 H₂O), guaranteeing predictable solubility and stability.

   • Heavy Metal Screening: ICP-MS validated limits: Arsenic (<0.5 ppm), Lead (<0.1 ppm), Cadmium (<0.05 ppm), Mercury (ND). Compliant with global pharmacopoeia (USP/EP/FCC).

   • Microbiological Control: Total Plate Count < 1000 CFU/g, Yeast & Mold < 100 CFU/g. Tested for pathogens (E. coli, Salmonella, S. aureus) with negative results.

2. Advanced Synthesis & Crystallization Technology

   • Controlled Reaction & Crystallization: Our process reacts high-purity magnesium carbonate with food-grade citric acid under precisely controlled temperature and concentration parameters. This promotes the formation of large, uniform nonahydrate crystals.

   • Multi-Stage Purification: The crystalline product undergoes gentle washing to remove any residual reactants or by-products, guaranteeing exceptional purity and a neutral taste profile.

   • Gentle Drying & Classification: Low-temperature, controlled-humidity drying preserves the nonahydrate structure (preventing efflorescence). The final product is gently milled and sieved to achieve a consistent, free-flowing powder.

3. Stability & Shelf-Life Superiority

   • Long-Term Stability: The well-defined crystal structure makes this form exceptionally stable. Accelerated studies confirm it retains its hydration level, chemical integrity, and physical properties for over 36 months when stored in cool, dry conditions (25°C/60% RH).

   • Low Hygroscopicity: In its proper crystalline form, it exhibits significantly lower moisture pickup compared to anhydrous or amorphous forms, ensuring excellent flowability and preventing caking during storage.

   • Light/Oxygen Protection: Nitrogen-flushed, moisture-barrier foil packaging with desiccant guarantees stability from factory to formulation.

Scientific & Functional Overview

1. A Trusted Pharmaceutical & Nutritional Ingredient

   • Active Pharmaceutical Ingredient (API) : Used in OTC and clinical nutrition products as a reliable source of magnesium for addressing deficiencies and supporting metabolic functions.

   • Superior Bioavailability: As an organic magnesium salt, it offers excellent bioavailability, essential for physiological roles including muscle relaxation, nerve transmission, and energy metabolism. [Reference: Magnes Res. 2018]

2. Controlled Solubility for Formulation Flexibility

   • Unique Dissolution Profile: Its relative insolubility in cold water, but ready solubility in dilute acid (gastric fluid), makes it ideal for:

     • Solid Dosage Forms: Ensures tablets and capsules remain intact and non-bitter during storage, yet dissolve predictably in the stomach.

     • Suspensions: Can be used to create stable, non-gritty suspensions where slow dissolution is desired.

   • Neutral Taste: The highly purified, crystalline form is virtually tasteless and odorless, preventing flavor interference in finished products.

3. Broad-Spectrum Application

   • Infant Nutrition: Recognized as a safe and suitable magnesium source for infant formula and follow-on formulas in major global markets (e.g., EU, US).

   • Specialized Nutrition: Ideal for clinical nutrition products, weight management formulas, and medical foods requiring precise mineral fortification.

   • Animal Health: Widely used in premium pet food and animal feed as a highly bioavailable mineral supplement.

Formulation-Ready Advantages

Application-Specific Benefits:

• Tablets & Capsules: Excellent compressibility and flow. The crystalline structure allows for high tablet hardness with low ejection force. No grittiness upon disintegration.

• Powdered Blends & Stick Packs: Acts as a free-flowing agent, preventing segregation. Remains stable and non-reactive with other vitamins and minerals.

• Infant Formula & Medical Foods: Meets stringent purity standards required for sensitive populations. Provides a reliable, non-reactive mineral source.

• Suspensions: Its low water solubility allows for the creation of palatable, stable liquid suspensions that do not settle or degrade quickly.

Supply Chain & Compliance Leadership

1. Audited Transparency

   • Full Traceability: Batch-specific Certificates of Analysis (COA) with complete heavy metal, microbial, and physical property data are always available.

   • Production Capacity: Multiple production lines across ISO 9001 and GMP-certified facilities ensure consistent supply for projects of any scale.

2. Regulatory Preparedness

   • Global Compliance: Meets Food Chemicals Codex (FCC), USP/NF, and EP standards. Full documentation for GRAS determination, EU Novel Food compliance, and other regional filings available.

   • Allergen Statement: Validated free from gluten, soy, dairy, nuts, and crustaceans (ELISA tested). Produced in dedicated allergen-managed facilities.

3. Ethical Certifications

   • Kosher & Halal Certified: Available upon request.

   • Non-GMO & Vegan: Sourcing and production processes ensure a final product suitable for all dietary preferences and lifestyles.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard Magnesium Citrate:

• Inconsistent Hydration: Variable water content (e.g., mixtures of anhydrous, dihydrate, nonahydrate) leads to inconsistent magnesium potency and unpredictable solubility.

• Poor Flow & Caking: Incorrectly processed material absorbs moisture, leading to poor powder flow, sticking, and caking in bulk containers.

• Amorphous Structure: Lack of defined crystallinity can result in poor compression characteristics and variable dissolution rates.

• Residual Impurities: Incomplete washing can leave bitter-tasting by-products, impacting the palatability of finished goods.

SRBio’s Manufacturing Edge:

• Guaranteed Crystalline Nonahydrate: Our controlled process ensures the consistent formation of the desired nonahydrate crystal structure, guaranteeing predictable physical properties.

• Formulator-Friendly Solubility: The unique balance of water insolubility/acid solubility is ideal for controlled-release and palatable solid dosage forms.

• Optimized Physical Properties: Consistent density and particle size ensure superior flow and compression, enabling high-speed manufacturing.

Technical Partnership Program

1. Co-Development Services

   • Custom Particle Engineering: We can tailor particle size distribution, from fine powders for direct compression to granular grades for improved flow.

   • Formulation Support: Our lab can assist with stability studies, dissolution testing, and compatibility assessments with other actives in your specific matrix.

2. Market-Ready Solutions

   • Custom Premixes: Combine nonahydrate with other vitamins, minerals, and excipients into a homogeneous, ready-to-use premix for your product.

   • Private Label Kits: Turnkey formulas for capsules, tablets, or powdered drink mixes for rapid market entry.

Receive 1kg/5kg trial batches with COA + MSDS within 72 hours

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We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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