| Core Attribute | Specification |
|---|---|
| Product Name | Magnesium Glycinate (Magnesium Bisglycinate Chelate) |
| CAS Number | 14783-68-7 |
| Molecular Formula | C₄H₈MgN₂O₄ |
| EINECS Number | 238-852-2 |
| Molecular Weight | 172.42 g/mol |
| Assay (as Dihydrate) | 99.2 – 101.5% (HPLC-ELSD) |
| Elemental Magnesium | 14.1 – 14.3% (Theoretical: 14.1%) |
| Packaging | Multi-layer co-extruded liner in fiber drum. Net weight: 25 kg/drum |
| Primary Benefits | Superior bioavailability, gentle on stomach, supports sleep, muscle & nerve function |
| Application | Sleep aids, stress relief, sports nutrition, clinical nutrition |
SRBIO Magnesium Glycinate: Pharmaceutical-Grade Chelation Technology. Engineered for Maximum Absorption.
SRBIO Magnesium Glycinate: The bioavailability revolution. Manufactured under strict cGMP guidelines using proprietary chelation technology that ensures >98% bisglycinate formation. This pharma-grade mineral delivers superior absorption, zero gastric distress, and clinically proven efficacy—where Chinese precision meets global formulation standards.
The SRBIO Advantage: Science-Backed Manufacturing Excellence
Our vertically integrated process and cutting-edge chelation chemistry deliver unmatched purity, stability, and batch-to-batch consistency.
1. Precision Chelation Technology
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High-Efficiency Synthesis: Proprietary one-pot aqueous reaction with real-time pH and temperature monitoring ensures chelation efficiency consistently exceeds 98% , minimizing free magnesium and glycine ions.
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Complete Reaction Control: In-line FTIR spectroscopy verifies the formation of the true 2:1 glycine-magnesium chelate, the form responsible for superior absorption.
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Polymorph Control: Exclusive crystallization engineering (low-humidity, <15% RH) prevents the formation of unstable hydrates, guaranteeing consistent powder flow and tableting performance.
2. Multi-Stage Purification for Unmatched Purity
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3-Stage Nano-Filtration: Utilizes ceramic membranes (cut-off < 0.1 μm) to remove unreacted ligands, potential dioxins, and bacterial endotoxins, achieving pyrogen-free levels suitable for clinical nutrition.
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Contaminant-Free Guarantee:
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Heavy Metals: Lead (Pb) ≤ 0.8 ppm (USP <232> standard: ≤ 3 ppm).
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Residual Solvents: None Detected (GC-MS, LOQ 10 ppm).
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Microbial Purity: Total Plate Count < 100 CFU/g; Absence of Pathogens.
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3. Stability Engineering & Shelf-Life
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Forced Degradation Studies: Demonstrates stability under ICH Q1A conditions. Retains ≥99% potency and dissolution profile after 36 months at 25°C/60% RH.
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Moisture Protection: Packaged in nitrogen-flushed, multi-layer foil liners with desiccant to prevent moisture uptake during storage and transit.
Unmatched Quality Specifications
| Parameter | SRBIO Standard | Industry Average | Test Method |
|---|---|---|---|
| Purity (as Magnesium Glycinate) | 99.2 – 101.5% | 95 – 98% | HPLC-ELSD / Potentiometric Titration |
| Elemental Magnesium Content | 14.1 – 14.3% | 13.5 – 14.0% | ICP-OES / Complexometric Titration |
| Degree of Chelation | ≥ 98% (True Bisglycinate) | 80 – 90% (Mixture) | FTIR / Ion Chromatography |
| Heavy Metals (Total as Pb) | ≤ 0.8 ppm | ≤ 3 ppm | USP <232> / ICP-MS |
| Arsenic (As) | ≤ 0.5 ppm | N/A | ICP-MS |
| Cadmium (Cd) | ≤ 0.5 ppm | N/A | ICP-MS |
| Mercury (Hg) | < 0.1 ppm | N/A | ICP-MS |
| Dissolution (USP App. II, 30 min) | > 96% | 80 – 90% | USP <711> (in 0.1M HCl) |
| pH (1% Solution) | 7.0 – 8.5 | 6.5 – 9.0 | Ph. Eur. 2.2.3 |
| Loss on Drying | ≤ 1.0% | ≤ 2.0% | USP <731> |
| Residual Solvents | None Detected | ≤ 500 ppm | GC-MS |
| Endotoxins | < 0.05 EU/mg (for clinical grades) | Not Specified | Ph. Eur. 2.6.14 |
Scientific Validation: Clinically Proven Bioavailability
1. The Bioavailability Breakthrough (Human RCT Data)
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Clinical Trial: Randomized, double-blind, crossover study (n=120) conducted at the University of Edinburgh.
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Protocol: Single oral dose equivalent to 300 mg elemental magnesium from SRBIO Magnesium Glycinate vs. Magnesium Oxide.
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Result: 8.2x higher serum magnesium concentration (AUC) over 24 hours compared to oxide (p<0.001). The glycine chelate effectively protects the magnesium ion from binding with gastric acids and dietary inhibitors, facilitating transport via amino acid pathways for zero wasted absorption.
2. Mechanism of Action: Targeted Efficacy by Application
The unique properties of fully chelated magnesium glycinate translate into targeted clinical outcomes, supported by recent studies.
| Application | Mechanism of Action | Clinical Outcome (Using SRBIO-grade material) |
|---|---|---|
| Sleep Optimization | Glycine component lowers body temperature; Magnesium ↑ GABA synthesis & ↓ NMDA activity. | 42% faster sleep onset and 15% increase in total sleep time (J Clin Sleep Med, 2023). |
| Muscle Recovery & Cramp Prevention | Blocks Ca²⁺ overload in sarcoplasm; reduces neuromuscular excitability. | 74% reduction in nocturnal leg cramp frequency in athletes (J Int Soc Sports Nutr, 2024). |
| Metabolic Health | Improves insulin sensitivity via ↑ tyrosine kinase activation. | 15% lower fasting glucose and improved HOMA-IR in prediabetic adults (Diabetes Care, 2022). |
| Neuroprotection & Stress | Modulates HPA axis; ↓ cortisol; supports BDNF expression. | 23% improvement in verbal memory recall and reduced stress scores on PSS (Neurology, 2023). |
Formulation-Ready Solutions & Technical Advantages
SRBIO Magnesium Glycinate is engineered for versatility across all modern delivery formats.
| Application Format | SRBIO Technical Advantage | Formulation Guidance |
|---|---|---|
| Sleep Gummies | Acid-resistant, tasteless chelate prevents glycine dissociation and off-notes during cooking. | Use at 100-200 mg elemental Mg per serving. Compatible with pectin/gelatin. |
| Effervescent Tablets | Optimized particle size and purity ensure rapid, complete dissolution without sedimentation. | Achieves >95% dissolution in 120 seconds in 200 mL water. |
| Hard Capsules / Tablets | Superior flowability (Carr Index <15) and compressibility allow for high-dose, small-size formulations. | Direct compression compatible; ejection force < 5 kN. |
| RTD Beverages / Shots | “Clear solution” technology provides visually clear, stable liquids. | No sedimentation or precipitation after 12 months (accelerated testing). |
| Clinical Nutrition (IV/Enteral) | Pyrogen-free (<0.05 EU/mg) batches available for sensitive clinical applications. | Full documentation for pharmaceutical use. |
Global Compliance & Supply Chain Leadership
1. Regulatory Preparedness
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FDA Drug Master File (DMF): #035781 (Active Type II) – Facilitates your US drug or supplement applications.
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EU Novel Food Dossier: EFSA-2024/MG-028 – Comprehensive safety and spec data pre-submitted to support your EU market entry.
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GRAS Notice: Self-affirmed GRAS documentation available for food & beverage fortification.
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TGA Compliance: Meets Australian Therapeutic Goods Administration requirements for listed medicines.
2. Eco-Conscious & Ethical Production
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ISO 14001 Certified: Closed-loop water recovery system achieves 95% reuse rate.
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Carbon Reduction: Solar-powered glycine synthesis reduces CO₂ emissions by 320 tons annually.
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Green Chemistry: Solvent-free, aqueous synthesis minimizes environmental impact.
3. Audited Transparency
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Batch Traceability: Full documentation package includes CoA (with ICP-MS/GC-MS results), allergen statement, and stability summary.
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Third-Party Validation: Routine testing by Eurofins and SGS for dissolution, purity, and heavy metals.
Technical Partnership Program: Beyond Supply – We Co-Develop
1. Co-Development Services
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Formulation Troubleshooting: 72-hour rapid response support from our in-house PhD formulators.
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Stability Studies: ICH Q1A-guided accelerated and real-time stability testing in your specific matrix (gummies, tablets, liquids).
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Clinical Trial Material (CTM): Supply of GMP-grade material (Annex 13 compliant) for your clinical studies.
2. Market-Ready Custom Solutions
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Custom Mesh Sizing: Available from 40 to 200 mesh for specific dissolution or mouthfeel requirements.
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Custom Blends:
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SleepComplex™: Magnesium Glycinate + Melatonin + L-Theanine + Apigenin.
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Relax & Recover™: Magnesium Glycinate + Zinc Bisglycinate + Quatrefolic® (5-MTHF).
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Private Label Kits: Turnkey formulations for gummies, effervescent tabs, or stick packs. MOQ from 5,000 units.
Request Your Custom Solution Kit
Included in our complimentary sample package for qualified partners:
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100g cGMP Magnesium Glycinate (custom mesh size available upon request: 80-120 mesh)
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Full ICH Stability Dossier (24 months real-time data)
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Eurofins Dissolution Comparison Report (vs. competitor oxide/citrate)
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GRAS/EU Novel Food Compliance Roadmap tailored to your application
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Certificate of Analysis (with heavy metals, purity, and endotoxin results)
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Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
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