| Parameter | Specification |
|---|---|
| Product Name | Natamycin (Pimaricin) |
| CAS Number | 7681-93-8 |
| EINECS Number | 231-683-5 |
| Molecular Formula | C₃₃H₄₇NO₁₃ |
| Molecular Weight | 665.75 g/mol |
| Specification | ≥99.0% (HPLC) |
| Test Method | HPLC-UV, Titration, ICP-MS (Heavy Metals) |
| Appearance | White to off-white to pale yellow crystalline powder |
| Packaging | 25 kg/drum with double food-grade polyethylene liners; smaller sizes available |
| Key Properties | Natural polyene macrolide antifungal, heat-stable, pH 3–9 active, non-toxic to bacteria |
| Application | Food preservation, dairy products, bakery goods, meat products, beverages, dietary supplements, functional foods |
Protect Your Formulations with SRBio Natural Natamycin
SRBio Natamycin is a high-purity, naturally derived antifungal agent produced by fermentation of Streptomyces natalensis. As the only internationally approved natural antifungal preservative for food applications, it offers broad-spectrum protection against yeast and mold without affecting bacterial flora. SRBio’s advanced fermentation and purification platform ensures consistent purity, excellent stability, and formulation-ready performance for a wide range of food, beverage, and dietary supplement applications.
Uncompromising Quality: SRBio’s Manufacturing Excellence
1. Precision Purity Control
| Parameter | SRBio Standard | Industry Typical | Test Method |
|---|---|---|---|
| Purity (HPLC) | ≥99.0% | 97.0% – 99.0% | HPLC-UV |
| Loss on Drying | ≤5.0% | ≤8.0% | Karl Fischer |
| pH (1% suspension) | 5.5 – 7.5 | Variable | pH Meter |
| Heavy Metals (Total) | <10 ppm | ≤20 ppm | ICP-MS |
| Lead (Pb) | <0.5 ppm | ≤1.0 ppm | ICP-MS |
| Arsenic (As) | <0.5 ppm | ≤1.0 ppm | ICP-MS |
| Cadmium (Cd) | <0.1 ppm | ≤0.5 ppm | ICP-MS |
| Mercury (Hg) | <0.05 ppm | ≤0.1 ppm | ICP-MS |
| Related Substances | ≤1.0% total impurities | ≤3.0% | HPLC-UV |
| Residual Solvents | Meets ICH Q3C guidelines | Variable | GC-FID |
2. Advanced Fermentation & Purification Technology
Controlled Fermentation Platform
SRBio utilizes optimized fermentation strains of Streptomyces natalensis under strictly controlled conditions (pH, temperature, dissolved oxygen, nutrient feed) to maximize yield and purity. The fermentation process is free from animal-derived components, ensuring a vegan-friendly product.
Multi-Stage Purification Process
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Microfiltration: Removes cellular debris and high-molecular-weight fermentation byproducts
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Solvent Extraction: Selective extraction using food-grade solvents to isolate natamycin
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Activated Carbon Treatment: Eliminates color bodies and trace organic impurities
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Controlled Crystallization: Optimized solvent system yields uniform crystalline particles with consistent morphology
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Low-Temperature Drying: Gentle drying preserves the integrity of the heat-sensitive polyene structure
Exceptional Stability Profile
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pH Stability: Active across pH 3–9, with optimal stability in neutral to slightly acidic conditions
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Thermal Stability: Retains activity under typical food processing temperatures (brief exposure up to 100°C)
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Light Sensitivity: Packaged in light-protected containers to prevent UV-induced degradation
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Long-Term Stability: Retains ≥98% potency after 24 months when stored at 2–8°C or under cool, dry, light-protected conditions
3. Natural & Clean Label Positioning
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Fermentation-Derived: Produced via natural fermentation, not chemical synthesis
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Non-GMO: Verified non-GMO production strains and raw materials
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Clean Label: Recognizable as a natural preservative; E-number E235 (EU) designation available
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No Residual Antibiotics: Rigorous purification ensures no detectable antibiotic residues
Scientific & Functional Overview for Food & Supplement Applications
1. Broad-Spectrum Antifungal Activity
Natamycin exhibits potent antifungal activity against a wide range of yeasts and molds, including:
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Yeasts: Candida, Saccharomyces, Zygosaccharomyces, Rhodotorula
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Molds: Aspergillus, Penicillium, Fusarium, Mucor, Alternaria
Mechanism of Action
Natamycin binds irreversibly to ergosterol in fungal cell membranes, disrupting membrane integrity and causing leakage of essential cellular components. This mechanism is highly specific to fungi and does not affect bacteria, making it ideal for applications where bacterial cultures are desired (e.g., cheese, fermented products).
2. Key Advantages Over Conventional Preservatives
| Feature | Natamycin | Sorbates / Benzoates |
|---|---|---|
| Antifungal Spectrum | Broad, effective against resistant strains | Moderate, some mold resistance |
| Bacterial Impact | None | May inhibit beneficial bacteria |
| pH Range | Active pH 3–9 | Effective only at low pH |
| Taste Impact | Neutral at use levels | May impart off-taste |
| Clean Label | Natural fermentation origin | Synthetic or chemical origin |
3. Food Preservation Applications
Natamycin is widely used to extend shelf life and maintain product quality in:
| Category | Application Method | Benefit |
|---|---|---|
| Cheese & Dairy | Surface spray, immersion, or coating | Prevents surface mold without affecting starter cultures |
| Bakery Products | Surface spray or dough incorporation | Extends shelf life of bread, cakes, and pastries |
| Meat Products | Surface spray or casing treatment | Prevents mold on sausages, ham, and cured meats |
| Beverages | Direct addition to juices, soft drinks, and alcoholic beverages | Prevents yeast spoilage in finished products |
| Fermented Foods | Surface treatment or addition | Protects without interfering with fermentation |
4. Dietary Supplement & Functional Food Applications
As a natural antifungal agent, natamycin is also used in:
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Probiotic Formulations: Protects probiotic products from fungal contamination without affecting beneficial bacteria
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Herbal Supplements: Prevents mold growth in moisture-sensitive botanical formulations
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Liquid Supplements: Extends shelf life of liquid and suspension products
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Functional Foods: Clean-label preservation for health-focused food products
Technical Specifications & Formulation-Ready Advantages
| Parameter | SRBio Natamycin Standard | Test Method |
|---|---|---|
| Appearance | White to off-white to pale yellow crystalline powder | Visual Inspection |
| Purity (HPLC) | ≥99.0% | HPLC-UV |
| Loss on Drying | ≤5.0% | Karl Fischer |
| pH (1% suspension) | 5.5 – 7.5 | pH Meter |
| Solubility | Slightly soluble in water; soluble in DMSO, acetic acid | USP <1236> |
| Bulk Density | 0.40 – 0.65 g/mL | USP <616> |
| Particle Size (D90) | ≤100 μm (customizable) | Laser Diffraction |
| Heavy Metals (Total) | <10 ppm | ICP-MS |
| Related Substances | Total impurities ≤1.0% | HPLC-UV |
| Residual Solvents | Meets ICH Q3C guidelines | GC-FID |
| Microbial Limits | Total aerobic count <100 CFU/g; absence of pathogens | USP <61> / <62> |
| Assay (Anhydrous Basis) | 97.0% – 102.0% | Titration / HPLC |
Formulation-Ready Benefits by Application:
| Application | Key Advantage |
|---|---|
| Surface Sprays & Washes | Readily dispersible in water; forms stable suspensions for spraying or dipping. |
| Coating Solutions | Compatible with film-forming agents (e.g., starches, cellulose derivatives) for protective coatings. |
| Direct Food Addition | Neutral taste does not affect flavor profile; stable in liquid foods. |
| Dietary Supplements | Suitable for incorporation into tablets, capsules, and powders; does not interfere with probiotic viability. |
| Functional Beverages | Stable in acidic and neutral pH beverages; heat-stable for pasteurization processes. |
| Fermented Products | Selective antifungal action preserves product integrity without affecting fermentation cultures. |
Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
Full Traceability: Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, related substances, heavy metals, microbiology, and physical properties. Complete fermentation and purification records are available for qualified client audits.
Rapid Sampling: 50 g or 500 g R&D samples shipped within 72 hours with full COA + MSDS.
2. Global Regulatory Compliance
| Certification / Compliance | Status |
|---|---|
| ISO 22000 | Certified (all production sites) |
| Kosher & Halal | Certified |
| Non-GMO | Verified; fermentation strains and raw materials are non-GMO |
| Allergen-Free Statement | Gluten-free, soy-free, dairy-free, egg-free, peanut-free (ELISA tested) |
| Vegan | Fermentation-derived, no animal inputs |
| EU Food Additive | E235 designation; compliant with EU regulations |
| FDA GRAS | Generally Recognized as Safe for food applications |
| China GB 2760 | Compliant with food additive standards |
| JECFA | Acceptable daily intake established |
3. Supply Chain Resilience
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Redundant Manufacturing: Multiple fermentation lines ensure uninterrupted supply
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Global Stock Hubs: Pre-positioned inventory in North America, Europe, and Asia for rapid fulfillment
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Capacity: 10 MT/month standard, expandable to meet growing demand
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Cold Chain Options: Temperature-controlled shipping available for extended shelf life requirements
Competitive Breakdown: SRBio vs. Market Alternatives
| Capability | SRBio Natamycin | Standard Market Grade |
|---|---|---|
| Purity (HPLC) | ≥99.0% | 97.0% – 99.0% |
| Batch-to-Batch Consistency | ±0.5% purity variance | ±2.0% or higher |
| Related Substances | ≤1.0% total impurities | ≤3.0% total impurities |
| Heavy Metals | <10 ppm total | ≤20 ppm or higher |
| Loss on Drying | ≤5.0% | ≤8.0% |
| Residual Solvents | ICH Q3C compliant | Variable, often unverified |
| Microbial Control | USP-compliant, pathogen-free | Variable |
| Appearance | Uniform crystalline powder | Inconsistent, may contain discoloration |
| Documentation | Full COA, traceability, regulatory dossiers | Limited or incomplete |
| Lead Time | 2–3 weeks (bulk orders) | 4–8 weeks, variable |
Technical Partnership Program
1. Co-Development Services
Formulation Support
Our applications lab can assist with:
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Solubility and dispersion optimization for spray and dip applications
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Stability testing in finished food and beverage matrices
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Compatibility studies with other preservatives, antioxidants, and food ingredients
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Efficacy testing against target spoilage organisms
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Heat stability validation for processed products
Analytical Method Transfer
We provide validated HPLC methods for accurate quantification of natamycin in finished food and supplement products, enabling seamless integration into your quality management system.
Custom Solutions
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Particle Size Optimization: Custom milling for specific application requirements (surface sprays, dry blends)
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Custom Formulations: Pre-dispersed suspensions or ready-to-use coating solutions
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Packaging Options: Light-protected, moisture-barrier packaging to preserve stability
2. Market-Ready Solutions
Custom Blends for Food Preservation
| Blend Name | Composition | Target Application |
|---|---|---|
| DairyShield™ | Natamycin + Lactic Acid + Calcium Chloride | Cheese surface treatment, dairy coatings |
| BakeryFresh™ | Natamycin + Citric Acid + Starches | Bakery surface sprays, dough additives |
| BeverageGuard™ | Natamycin + Potassium Sorbate + Ascorbic Acid | Juices, soft drinks, energy beverages |
| ProbioticProtect™ | Natamycin + Maltodextrin | Probiotic supplement stabilization |
Private Label Ready
Turnkey formulations available for:
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Surface spray solutions (ready-to-use)
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Coating powders (for dry application)
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Liquid suspensions (for dip tanks)
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Pre-measured sachets for food processing
Partner with SRBio for Natural, High-Purity Natamycin
Ready to protect your food, beverage, or supplement formulations with natural, high-purity natamycin? Request custom samples, technical dossiers, or discuss co-development opportunities for your next-generation preservation solutions.
→ Email: admin@plantextractssr.com
