Parameter	Specification
Chemical Name	Zinc (II) N-(3-aminopropionyl)-L-histidinate
CAS Number	107667-60-7
Molecular Formula	C₉H₁₂N₄O₃Zn
Molecular Weight	289.61 g/mol
Purity (HPLC)	≥99.0%
Assay (Carnosine)	76.0% – 80.0%
Assay (Zinc)	21.5% – 23.0%
Test Method	HPLC / Titration
Packaging	25kg/drum, double food-grade poly bags inside. Nitrogen-flushed foil packaging available.
Main Benefits	Gastrointestinal mucosa protection, ulcer healing, antioxidant, anti-inflammatory
Application	Pharmaceuticals, nutraceuticals, functional foods, veterinary medicine

Targeted Gut Health Solution: SRBio Polaprezinc (L-Zinc Carnosine)

SRBio Polaprezinc is a high-purity, chelated compound of L-carnosine and zinc, produced through patented crystallization technology. As a clinically validated gastrointestinal mucosal protective agent, it offers a dual-action mechanism: zinc promotes tissue repair and regeneration, while L-carnosine provides antioxidant and anti-inflammatory effects. This unique synergy makes Polaprezinc the gold-standard ingredient for gastric health applications, from pharmaceutical ulcer treatments to daily gut-support nutraceuticals.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity Control

2. Advanced Chelation & Crystallization Technology

• Proprietary Synthesis Process:

  • Precision Chelation: Our patented process ensures stoichiometric 1:1:1 molar ratio of zinc ion, L-carnosine, and water molecule, guaranteeing consistent bioactivity.

  • Multi-Stage Crystallization: Controlled cooling crystallization produces uniform crystals with optimal particle size distribution.

  • Gentle Drying: Low-temperature vacuum drying preserves molecular integrity and prevents degradation.

• Particle Size Control:

  • Standard grade: 70% through 80 mesh.

  • Customizable particle size available for specific formulation needs (e.g., direct compression, suspensions).

• Annual Capacity: 40+ metric tons of high-purity Polaprezinc, with flexible production scheduling to match customer demand cycles.

3. Stability & Shelf-Life Superiority

• Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH (ICH Q1A tested).

• pH Adaptability: Stable in acidic environments (pH 1.2-3.0, typical gastric fluid); controlled release in neutral intestinal fluid (pH 6.8-7.4) to avoid systemic zinc overload.

• Formulation Compatibility: No discoloration or efficacy loss in solid dosage forms after 24 months of storage. Microencapsulated grade available for liquid formulations to prevent sedimentation.

Scientific Evidence: Mechanism & Clinical Efficacy

1. Gastrointestinal Mucosa Targeting

• Mechanism of Action:

  • Site-Specific Adhesion: Polaprezinc adsorbs to damaged gastric mucosa via electrostatic interaction, forming a protective barrier that lasts >6 hours (vs. 1-2 hours for ordinary zinc supplements).

  • Zinc Component: Promotes epithelial cell proliferation and collagen synthesis to accelerate mucosa repair.

  • Carnosine Component: Inhibits reactive oxygen species (ROS) and inflammatory factors (TNF-α, IL-8) to reduce mucosal irritation and inflammation.

• Clinical Outcomes:

  • ↑82% ulcer healing rate after 4 weeks in clinical trials (vs. 56% for placebo) – Japanese pharmaceutical study.

  • Significant reduction in gastric mucosal injury scores in NSAID-induced gastropathy models.

2. Antioxidant & Anti-Inflammatory Effects

• Mechanism: L-carnosine acts as a direct scavenger of hydroxyl radicals and singlet oxygen, while zinc stabilizes cell membranes and inhibits oxidative stress pathways.

• Clinical Outcomes:

  • Reduces markers of oxidative stress (↓MDA, ↓8-OHdG) in gastric tissue.

  • Downregulates pro-inflammatory cytokines in models of chronic gastritis.

3. Safety Profile

• Low Toxicity: LD₅₀ >5,000 mg/kg (rat, oral).

• Long-Term Safety: No adverse effects observed in 12-month long-term toxicity studies.

• Global Regulatory Status:

  • Japan: Listed as a prescription drug ingredient for peptic ulcer treatment.

  • EU: Approved as a Novel Food ingredient (NF) for nutraceuticals.

  • China: Included in the “Catalog of Food Additives and Nutritional Fortifiers.”

Formulation-Ready Advantages

Application-Specific Benefits:

• Pharmaceuticals:

  • Ulcer Treatment Tablets: 150 mg/tablet formulation clinically proven for peptic ulcer and chronic gastritis.

  • Combination Therapy: Can be co-formulated with bismuth subcitrate for enhanced ulcer repair.

• Nutraceuticals:

  • Gastrointestinal Care Supplements: Ideal for daily gut health maintenance.

  • Prenatal Vitamins: Reduces gastric discomfort during pregnancy when combined with iron and other minerals.

  • “Gastric-Friendly” Powders: Synergistic blends with L-glutamine (e.g., 20 mg Polaprezinc + 500 mg glutamine).

• Functional Foods:

  • Gastric-Friendly Meal Replacements: Fortification of oatmeals, shakes, and solid beverages targeting consumers with irregular diets.

  • Microencapsulated Grade: Prevents sedimentation in liquid formulations (oral suspensions, RTD beverages).

Supply Chain & Compliance Leadership

1. Audited Transparency & Traceability

• Full Traceability: Batch-specific Certificate of Analysis (COA) with complete impurity, heavy metal, and microbial data. Batch records and reference samples retained for every production lot.

• Dual Manufacturing Sites: Production across two certified facilities ensures business continuity and supply security.

• On-Time Delivery: 99.7% on-time delivery rate with global logistics expertise (FOB, CIF, DDP terms).

2. Global Regulatory Certifications

3. Supply Chain Resilience

• Strategic Raw Material Partnerships: Long-term agreements with key suppliers guarantee production stability.

• Safety Stock: Strategic inventory maintained to accommodate urgent requirements.

• Global Markets Served: North America, European Union, Southeast Asia, Australia, South America, Middle East.

• Audit Support: Full support for virtual and on-site audits; pre-organized audit packages available for qualified partners.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard Polaprezinc/Zinc Carnosine:

• Inconsistent Chelation: Poor stoichiometric control leads to variable zinc/carnosine ratios and reduced efficacy.

• Particle Size Variability: Inconsistent crystal size causes blending and flow issues in manufacturing.

• Limited Stability Data: Many suppliers lack comprehensive stability and safety documentation.

• Regulatory Gaps: Insufficient dossiers for global market approvals (EU Novel Food, FDA, etc.).

SRBio’s Technology Edge:

Partner Success Stories

Global Nutraceutical Brand:
“As our strategic Polaprezinc supplier for over 2 years, SRBio’s consistent quality and reliable supply have been crucial for our bestselling gastrointestinal support product line.”
— Procurement Director

European Pharmaceutical Company:
“The detailed CMC and stability data package from SRBio was instrumental in accelerating our regulatory filing. Their compliance rigor is truly partnership-level.”
— Regulatory Affairs Manager

US Supplement Manufacturer:
“Switching to SRBio for Polaprezinc provided us with a superior balance of purity, bioavailability, and cost-effectiveness. Their technical team collaborated seamlessly with our R&D on a novel chewable format.”
— Head of Product Development

Technical Partnership Program

1. Co-Development Services

• Custom Formulations:

  • Gastroprotective Complexes: Polaprezinc + Bismuth Subcitrate for enhanced ulcer healing.

  • Gut Health Blends: Polaprezinc + L-Glutamine + Zinc Carnosine + Deglycyrrhizinated Licorice (DGL).

  • Prenatal Support: Polaprezinc + Iron + Folate (reduces gastric discomfort).

• Custom Particle Engineering: Tailored particle size for direct compression, suspensions, or controlled release.

• Stability Studies: ICH-guided protocols for your specific formulation matrix (tablets, capsules, liquids, gummies).

• New Product Development: Collaborative R&D to expand health applications (e.g., oral mucositis, veterinary gut health).

2. Market-Ready Solutions

• Private Label Kits: Turnkey formulas for gastrointestinal care capsules, powders, and chewable tablets.

• Regulatory Support: Comprehensive dossiers for pharmaceutical (IND/NDA) and nutraceutical (NDI, Novel Food) submissions.

• Technical Troubleshooting: Process optimization support for manufacturing challenges.

• Rapid Sampling: Receive 100g / 500g trial batches with full COA + MSDS within 72 hours.

Request Your Polaprezinc Discovery Kit

Includes:

• 100g High-Purity Polaprezinc (≥99.0%, HPLC-verified)

• Full Certificate of Analysis (COA, TDS, MSDS)

• Stability Data Summary (24 months, ICH-compliant)

• Regulatory Dossier Excerpts (EU Novel Food, Japan pharma)

• Formulation Guide for Gastrointestinal Applications

Partner with SRBio for Premium, Clinically Validated Polaprezinc

Choose SRBio as your trusted Polaprezinc partner for:

• Guaranteed Supply Continuity backed by dual-site production

• Uncompromising Quality Standards verified by third-party certifications

• Competitive Total Cost of Ownership through efficient production

• Strategic Technical Partnership with joint development support

• Proven Product Performance supported by comprehensive data

• Reliable Global Logistics with extensive regional experience

Start Your Supplier Qualification:

→ Email: admin@plantextractssr.com
→ Phone: +86-13720408392
→ WhatsApp/WeChat: +86-13720408392

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