Latin Name	Glycine max (Soybean) and other natural plant oils
CAS Number	83-48-7
Molecular Formula	C₂₉H₄₈O
Molecular Weight	412.69 g/mol
Specification	Stigmasterol 20%, 90%, 95% (HPLC)
Test Method	HPLC (for Stigmasterol content)
Appearance	White crystalline powder
Packaging	In paper-drums with double polyethylene bags inside. Net weight: 25kg/drum
Main Benefits	Key intermediate for steroid hormone synthesis, supports healthy cholesterol levels, anti-inflammatory properties, skin health
Application	Pharmaceutical intermediates, dietary supplements, functional foods, cosmetics

The Versatile Phytosterol for Advanced Applications: Premium Stigmasterol by SRBio

SRBio Stigmasterol is a high-purity, naturally occurring unsaturated phytosterol, expertly separated from mixed plant sterols derived from sustainable sources like soybean, rapeseed, and other natural vegetable oils. As a crucial bioactive compound, it serves a dual role: a valuable nutritional ingredient for supporting cardiovascular health, and an indispensable raw material for the synthesis of vital pharmaceutical steroids, including progesterone, corticosteroids, and vitamin D3. Our advanced separation and purification technologies ensure the highest purity and consistency for your specialized applications.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity & Composition Control

   • Guaranteed Stigmasterol Content: Our advanced separation process ensures precise and consistent specifications, typically 20%, 90%, or 95% Stigmasterol (HPLC) , with tight control over other phytosterol components (e.g., β-sitosterol, campesterol).

   • High Purity Assurance: Rigorous quality control ensures the final product is free from process impurities and residual solvents.

   • Heavy Metal Screening: ICP-MS validated limits: Arsenic (<0.5 ppm), Lead (<0.1 ppm), Cadmium (<0.05 ppm), Mercury (ND). Compliant with global pharmaceutical and food safety standards.

   • Microbiological Control: Total Plate Count < 1000 CFU/g, Yeast & Mold < 100 CFU/g. Tested for pathogens (E. coli, Salmonella) with negative results.

2. Advanced Separation & Purification Technology

   • Multi-Step Fractionation: We utilize a proprietary series of advanced separation technologies—including high-performance chromatography and multi-stage crystallization—to isolate and purify stigmasterol from mixed plant sterol sources with exceptional efficiency and purity.

   • Natural Sourcing: Starting from non-GMO, sustainably sourced vegetable oils, our process ensures a natural product free from synthetic additives.

   • Gentle Processing: Low-temperature processing steps throughout the fractionation and purification cascade protect the molecular integrity and stability of this sensitive sterol.

3. Stability & Shelf-Life Superiority

   • Long-Term Stability: As a stable crystalline powder, our stigmasterol retains its chemical integrity and physical properties for over 36 months when stored in a cool, dry place, protected from light.

   • Oxidation Control: Careful processing and packaging minimize exposure to oxygen, preventing oxidation and ensuring long-term stability.

   • Light/Oxygen Protection: Nitrogen-flushed, moisture-barrier foil packaging with desiccant guarantees stability from factory to your formulation or synthesis process.

Scientific & Functional Overview

1. Essential Pharmaceutical Intermediate

   • Key Starting Material: Stigmasterol is a fundamental building block for the semi-synthesis of numerous high-value pharmaceutical steroids. Its unsaturated side chain makes it a preferred precursor for the production of:

     • Progesterone and other sex hormones

     • Corticosteroids (like cortisone and hydrocortisone)

     • Vitamin D3 (cholecalciferol)

   • Biochemical Research: Widely used in biochemical research and as a reference standard.

2. Cardiovascular & Metabolic Health Support

   • Cholesterol Reduction: As a phytosterol, stigmasterol structurally resembles cholesterol and can help manage healthy cholesterol levels by competing with dietary and biliary cholesterol for absorption in the intestines. [Reference: Nutrients. 2018; 10(8): 999]

   • Anti-inflammatory Properties: Exhibits anti-inflammatory effects that may contribute to overall cardiovascular and joint health.

3. Cosmeceutical & Dermatological Applications

   • Skin Barrier Repair: Helps support and restore the skin’s natural barrier function, improving hydration and protection against environmental stressors.

   • Anti-Aging & Soothing: Contributes to anti-aging formulations by soothing irritation and supporting collagen health. Its emollient properties make it a valuable addition to creams and lotions for sensitive or mature skin.

4. Traditional & Modern Wellness

   • Multi-System Support: Traditionally used in various herbal medicine systems. Modern applications explore its potential benefits for immune modulation, hair health, and overall vitality.

Formulation-Ready Advantages

Application-Specific Benefits:

• Pharmaceutical Synthesis: High purity and consistent composition are critical for predictable yields and efficient synthesis of steroid APIs. Our product meets the stringent requirements for use as a chemical intermediate.

• Dietary Supplements: Ideal for formulating into capsules (softgels or hard-shell) with oil carriers, or for use in tablet formulations aimed at cholesterol management and heart health.

• Cosmetics & Personal Care: Easily incorporated into the oil phase of emulsions for anti-aging creams, serums, and hair care products. Its stability and skin-friendly profile are highly valued.

• Functional Foods: Can be incorporated into fat-based food products, spreads, and fortified foods to deliver the benefits of plant sterols.

Supply Chain & Compliance Leadership

1. Audited Transparency

   • Full Traceability: Batch-specific Certificates of Analysis (COA) with complete purity, heavy metal, and physical property data are always available.

   • Sustainable Sourcing: We partner with certified, sustainable sources for our raw vegetable oils, ensuring responsible supply chains.

2. Regulatory Preparedness

   • Global Compliance: Meets relevant pharmacopoeial standards (e.g., USP/EP) for related substances where applicable. Full documentation for pharmaceutical and nutraceutical registration available.

   • Allergen Statement: Validated free from gluten, soy, dairy, nuts, and crustaceans (ELISA tested). Produced in dedicated allergen-managed facilities.

3. Ethical Certifications

   • Kosher & Halal Certified: Available upon request.

   • Non-GMO & Natural: Sourcing and production processes ensure a final product that is naturally Non-GMO.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard Stigmasterol:

• Inconsistent Purity: Variable stigmasterol content and inconsistent ratios of other sterols can lead to unpredictable results in sensitive pharmaceutical synthesis.

• Oxidation & Degradation: Poorly processed material is prone to oxidation, reducing its efficacy and shelf life.

• High Impurity Profile: Elevated levels of process impurities or other phytosterols can limit its use in high-value applications.

• Poor Solubility & Handling: Variable crystal forms can lead to poor flow and difficult handling in manufacturing.

SRBio’s Manufacturing Edge:

• Precise & Consistent Purity: Our advanced fractionation guarantees reliable stigmasterol content for predictable performance.

• Superior Stability: Gentle processing and antioxidant protection ensure a stable, high-quality product with extended shelf life.

• Pharma-Grade Potential: Suitable for use as a chemical intermediate in demanding pharmaceutical synthesis.

• Natural & Clean: Sourced from non-GMO plants with no residual solvents.

Technical Partnership Program

1. Co-Development Services

   • Custom Purification: We can work with you to tailor the stigmasterol purity and profile to your specific synthetic or formulation needs.

   • Formulation Support: Our lab can assist with stability testing and compatibility assessments in your specific product matrix (e.g., oil-based suspensions, emulsions).

2. Market-Ready Solutions

   • Pharmaceutical Intermediates: Reliable supply of high-purity stigmasterol for your steroid synthesis projects, backed by comprehensive technical data.

   • Custom Blends for Nutraceuticals: Combine stigmasterol with other phytosterols (e.g., beta-sitosterol) or heart-healthy ingredients into a ready-to-use premix.

   • Private Label Kits: Turnkey formulas for softgels or capsules for rapid entry into the cholesterol-management market.

Receive 1kg/5kg trial batches with COA + MSDS within 72 hours

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