Next-Generation Liver Health & Hangover Relief: SRBio High-Purity DHM
(China Organic Farm Direct · 99.2% Purity · Pharmaceutical-Grade Process)
SRBio’s Dihydromyricetin (DHM) is more than a simple flavonoid extract. It is a genomics-traced, pharmaceutical-grade active ingredient. By integrating our 200-hectare certified organic tea farms (QTPP-certified) in Fujian with our patented subcritical water/CO₂ hybrid extraction technology, we deliver DHM powder with an average purity of 99.2%—far exceeding the 92-95% industry average—providing global brands with a scientifically validated solution for alcohol metabolism support and liver protection.
Uncompromising Quality: SRBio’s Manufacturing Excellence
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Genomics Sourcing & Vertically Integrated Supply Chain
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Own Organic Farms: We control quality at the source with 200 hectares of QTPP-certified organic farms in Fujian for Ampelopsis grossedentata (Vine Tea). Soil pH is strictly maintained at 5.2-6.0 to optimize natural flavonoid accumulation.
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DNA Barcoding Authentication: Every raw material batch is authenticated via DNA barcoding (ITS2 + psbA-trnH markers). Batches with <98% genetic match are rejected.
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Infrared Low-Temperature Drying: Raw material is dried at 45°C using infrared technology, reducing water activity to <0.3 and preserving maximum natural bioactivity.
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Patented Extraction & Pharmaceutical-Grade Purification
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Subcritical Water/CO₂ Hybrid Technology: Our patented hybrid technology achieves a highly concentrated 12:1 ratio, efficiently enriching target flavonoids far beyond the standard 20-25:1 range.
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Dynamic MAC (Mixed Adsorbent Column) Technology: During extraction, MAC technology is used to specifically capture and enrich DHM, significantly boosting extraction efficiency.
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Preparative HPLC Purification: Final purification is performed using a Waters Preparative HPLC System (C18 column, 250×50mm, methanol/water gradient) to target and remove key impurities like Dihydroquercetin (DHQ) , ensuring DHQ <0.5%.
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Triple Recrystallization: Three cycles of recrystallization (ethyl acetate/hexane) achieve pharmaceutical-grade purity standards.
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Particle Engineering & Long-Term Stability
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Micronization: Processed with a jet mill to achieve particle size D90 < 15 microns, significantly improving dissolution rate and bioavailability.
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Lyophilization (Freeze-Drying): Performed at -45°C/0.01mbar to control moisture to <1%, ensuring excellent stability.
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Protective Packaging: Packaged in trilayer foil bags, nitrogen-flushed with integrated oxygen scavengers, guaranteeing >98% purity retention after 24 months under ICH Q1A(R2) accelerated stability testing (40°C/75% RH).
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Technical Specifications: SRBio vs. Market Alternatives
| Parameter | SRBio DHM | Industry Standard |
|---|---|---|
| Purity (HPLC-ELSD) | ≥99.2% (Batch SR2301-789 avg) | 92–95% |
| Key Impurity (DHQ) | <0.5% | Often uncontrolled or >2% |
| Extraction Ratio | 12:1 (High concentration) | 20–25:1 |
| Particle Size (D90) | <15 microns (Micronized, fast dissolution) | >50 microns |
| Heavy Metals (Pb) | <0.5 ppm (ICP-MS) | <1.0 ppm (or unspecified) |
| Pesticide Residue | Meets EU MRLs (198 tests) | Often only a few tests |
| Total Aerobic Count | <100 CFU/g (USP <61>) | <1000 CFU/g |
| Residual Solvents (Ethanol) | <500 ppm (ICH Q3C compliant) | May be higher or unspecified |
| Shelf Life (24 months/25°C) | Purity retention >98% (ICH verified) | Often no data |
Formulation & Application Solutions
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Hangover Relief & Liver Health
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Core Application: Used in capsules, tablets, or liquid shots taken before or after alcohol consumption to accelerate metabolism, protect the liver, and reduce next-day discomfort.
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SRBio Anti-Hangover Complex Formula: We offer a scientifically designed synergistic formula including:
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Core: DHM (High-Purity)
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Synergistic Ingredients: Hovenia dulcis Extract, Milk Thistle Extract, Cactus Pear Extract, Korean Pear Extract, Panax Ginseng Extract. This multi-target formula accelerates alcohol breakdown, neutralizes free radicals, and replenishes key nutrients.
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Functional Sobriety Beverages
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Clear RTD Beverages: Our micronized DHM with enhanced solubility allows for the development of clear, portable functional shots or drinks to be consumed during or after drinking.
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Sports Recovery & Metabolic Health
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Sports Nutrition: DHM’s antioxidant and anti-inflammatory properties make it ideal for post-exercise recovery formulas, helping to reduce exercise-induced oxidative stress.
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Metabolic Support: Based on its activity in regulating glucose and lipid metabolism, DHM can also be used in supplements supporting healthy blood sugar and lipid levels.
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Quality Control: Four-Tiered Testing Protocol
| Phase | Tests Performed | Equipment | Acceptance Criteria |
|---|---|---|---|
| Raw Material | 198 Pesticides, Aflatoxins, Cadmium | GC-MS/MS, LC-QTOF | EU MRLs compliant |
| In-Process | DHM/DHQ Ratio, Residual Solvents | UPLC-PDA, Headspace GC | DHQ <0.5%, Ethanol <500 ppm |
| Release | Purity (HPLC-ELSD), Heavy Metals, Microbiology | ICP-MS, USP <61> | Pb <0.5 ppm, TAMC <100 CFU/g |
| Stability | ICH Q1A(R2) (40°C/75% RH, 24 months) | Forced Degradation Chamber | Purity retention >98% at 24 months |
Supply Chain & Compliance Leadership
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Comprehensive Regulatory Readiness
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Pre-Audited Dossiers: We provide key documentation for your global registrations, including:
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EU (EFSA): Novel Food application dossier.
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Complete Analytical Reports: Each batch ships with a detailed Certificate of Analysis (COA) including purity, impurity profile, heavy metals, pesticides, and microbiology.
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Ethical & Sustainable Sourcing
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Organic Certified: Raw material is sourced from our QTPP-certified organic farms, ensuring pesticide-free and sustainable cultivation.
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Fully Traceable: GPS-tagged cultivation plots provide a complete chain of custody from soil to finished product.
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Technical Partnership Program
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Co-Development Services
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Formulation Support: Our R&D team can assist in incorporating DHM into complex matrices, such as liquid beverages, softgels, or synergistic herbal blends.
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Stability Studies: ICH-guided stability testing for your specific formulation matrix.
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Market-Ready Solutions
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Custom Blends: We can provide customized pre-mixes containing DHM tailored to your target market, such as our professionally developed SRBio Anti-Hangover Complex Formula.
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Rapid Sampling: Trial batches (1kg) available for shipment within 72 hours, with full COA.
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📦 Partner with the Neuro-Nutrition Leader
Request samples, clinical dossiers, or discuss co-development today.
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📞 English Support: +86-13720408392
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📧 Email: admin@plantextractssr.com
SRBio Dihydromyricetin (DHM): High Purity for a New Era of Liver Health.
Shipping & Packing Information
OEM SERVICE
We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
