Basic Product Information
| Parameter | Details |
|---|---|
| Latin Name | Stephania japonica (Thunb.) Miers |
| Family | Menispermaceae |
| CAS Number | 481-49-2 (Cepharanthine) |
| Used Plant Part | Roots, stems, and leaves |
| Specification | 4:1, 10:1, 20:1 (ratio extracts) or Cepharanthine 80%–98% (HPLC) |
| Test Method | HPLC (for Cepharanthine content); TLC (for identification) |
| Appearance | White to off-white or brown-yellow powder (depending on specification) |
| Active Compound | Cepharanthine (bisbenzylisoquinoline alkaloid) |
| Molecular Formula | C₃₇H₃₈N₂O₆ (Cepharanthine) |
| Molecular Weight | 606.71 g/mol (Cepharanthine) |
| Loss on Drying | ≤5.0% |
| Heavy Metals | ≤10 ppm (total) |
| Packaging | Paper drums with double food-grade poly bags; 25 kg/drum; 1 kg, 5 kg small packs available |
| Storage | Keep well closed, protected from light, dry, at room temperature |
| Shelf Life | 24 months under proper storage |
Premium Stephania Japonica Extract by SRBio – Standardized Bioactive Alkaloid Complex
SRBio Stephania Japonica Extract is a high-purity botanical extract derived from the roots and stems of Stephania japonica (Thunb.) Miers, a perennial woody vine belonging to the Menispermaceae family. This plant is widely distributed across eastern and southern Asia, including China, Japan, Korea, India, and Southeast Asian countries. The name “Stephania” originates from the Greek word for “a crown,” referring to the crown-like arrangement of the plant‘s anthers.
The extract is standardized to contain bisbenzylisoquinoline alkaloids, with Cepharanthine being the primary bioactive marker compound. Numerous alkaloids have been isolated from the tuberous roots and stems of Stephania japonica, including epistephanine, hypoepistephanine, stepholine, stebisimine, and insularine, alongside the major component Cepharanthine. The plant is recognized for its high levels of Cepharanthine, which has attracted global scientific attention in recent years.
SRBio Stephania Japonica Extract is produced using advanced extraction and purification technologies that preserve the natural integrity of the active alkaloid profile. Our high-purity grade (≥98% Cepharanthine) undergoes rigorous HPLC testing to ensure consistent potency and quality across every batch, making it an ideal choice for premium health products and functional formulations.
Manufacturing & Quality Excellence
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Raw material sourcing: High-quality Stephania japonica plants are harvested from controlled cultivation regions in China (Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Henan, Hubei, Hunan, Sichuan and other regions). Only roots and stems at optimal maturity are selected for extraction.
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Extraction process: Advanced solvent extraction followed by multi-stage purification and column chromatography to isolate and concentrate bioactive alkaloids, particularly Cepharanthine.
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Customizable specifications: Available in multiple formats — 4:1, 10:1, and 20:1 ratio extracts for general applications, or high-purity Cepharanthine 80%–98% for targeted formulations.
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Quality testing: Each batch is tested for assay (HPLC), heavy metals (Pb, As, Cd, Hg), loss on drying, microbial purity, and residual solvents before release.
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Certifications: Our facility complies with cGMP, ISO 22000, and HACCP standards. Kosher, Halal, and Non-GMO certifications available upon request.
Core Product Advantages
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Standardized alkaloid content — Available in multiple specification options (4:1, 10:1, 20:1 ratio extracts or Cepharanthine 80%–98%), allowing manufacturers to select the ideal potency level for their specific formulation needs.
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Rich alkaloid profile — Contains a diverse array of bioactive bisbenzylisoquinoline alkaloids, including Cepharanthine, epistephanine, hypoepistephanine, stepholine, stebisimine, and insularine.
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Powerful antioxidant activity — The extract demonstrates strong antioxidative capacity, helping combat oxidative stress and supporting cellular health.
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Anti-inflammatory properties — Scientific evidence indicates anti-inflammatory activity, making it a valuable ingredient for formulations aimed at managing inflammatory responses.
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Antimicrobial benefits — Exhibits antibacterial and antifungal activities, contributing to preservation and microbial balance in finished products.
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Metabolic support — Research has suggested anti-diabetic and anti-hyperglycemic effects, positioning the extract as a potential supportive ingredient for metabolic health formulations.
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Clean and versatile — No additives, no preservatives, no GMOs, no artificial colors. Suitable for clean-label product development.
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Excellent formulation compatibility — Compatible with capsules, tablets, powders, and functional food matrices.
Physical & Formulation Properties
| Property | Value / Description |
|---|---|
| Appearance | White to off-white powder (high-purity grade); brown-yellow powder (ratio extracts) |
| Odor | Characteristic, neutral |
| Solubility | Soluble in organic solvents (ethanol, DMSO); limited water solubility |
| Bulk density (untapped) | 0.4 – 0.6 g/mL |
| Tapped density | 0.6 – 0.8 g/mL |
| Particle size (D90) | < 80 mesh (standard); custom sizes available on request |
| Hygroscopicity | Low to moderate — stable under normal humidity |
| Flowability | Moderate — suitable for encapsulation and tableting with appropriate excipients |
| Compatibility | Compatible with most excipients and other botanical extracts |
Application Benefits
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Dietary supplements
Capsules, tablets, and powder formulations for immune support, antioxidant protection, and overall wellness. The high-purity Cepharanthine grade (98%) is particularly suitable for targeted nutraceutical applications. -
Functional foods
Fortified foods, nutritional bars, and beverage mixes. The clean taste profile and neutral odor allow seamless integration without affecting the original flavor of the final product. -
Cosmetics & personal care
Used in anti-aging creams, serums, and UV-protection formulations. The antioxidant properties help delay aging and protect against UV radiation damage. -
Health products
Widely used as an ingredient in health supplement products for immune system support and promoting cellular health.
Traditional & Ethnobotanical Background
Stephania japonica has a long history of traditional use across Asia. In traditional Chinese medicine, the plant is used for its heat-clearing, detoxifying, wind-dispelling, pain-relieving, and swelling-reducing properties. It has been traditionally used for sore throat, carbuncles, boils, snake bites, rheumatic arthralgia, stomach pain, and athlete‘s foot edema.
In the Philippines, Stephania japonica is known as a cure for itches; in Papua New Guinea, the roots and juice are applied to sores, cuts, and stings. In India, the roots are used in the treatment of diarrhoea, dyspepsia, urinary diseases, and heart ailments. In Indonesia, the leaves are commonly used to produce edible green grass jelly. Scientific evidence supports many of these traditional applications, including antioxidant, anti-inflammatory, antibacterial, and analgesic activities.
Supply Chain & Compliance
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Production capacity: 300 metric tons per year, expandable to meet growing demand.
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Lead time: 10–15 days for stock quantities; 20–25 days for custom specifications.
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Documentation support: COA, MSDS, allergen statement, GMO‑free declaration, and specification sheet provided with each shipment.
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Regulatory compliance: Compliant with international food supplement standards. Heavy metals and residual solvents strictly controlled to meet global safety requirements.
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Third‑party testing: Available upon request for heavy metals, residual solvents, pesticide residues, and stability studies.
Technical Support & Custom Solutions
SRBio offers comprehensive technical support to ensure seamless integration of our Stephania Japonica Extract into your formulations:
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Custom specification options: Choose from ratio extracts (4:1, 10:1, 20:1) or high-purity Cepharanthine (80%, 95%, 98%) based on your application needs.
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Formulation assistance: Our technical team can recommend appropriate usage levels and compatibility guidelines for capsules, tablets, and powder blends.
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Custom particle size: Micronized or granulated forms available to improve flowability and blend uniformity.
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Premix blends: Pre‑mixed with complementary botanicals or excipients to streamline your production process.
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Packaging options: 1 kg, 5 kg, 25 kg, or custom bulk packaging with moisture‑barrier protection.
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Regulatory support: Provide technical documentation for product registrations worldwide.
Why Choose SRBio Stephania Japonica Extract?
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Premium quality assurance — Every batch is tested for alkaloid content by HPLC to guarantee consistent potency and purity.
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Flexible specifications — Multiple potency options available to suit diverse application requirements, from general wellness products to high-purity specialized formulations.
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Traceable supply chain — Full traceability from plant sourcing to finished extract ensures transparency and quality control.
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Scientific backing — The extract is derived from a plant species with extensive phytochemical characterization and documented bioactive properties.
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Customer‑centric service — Small minimum order quantity (MOQ 1 kg) for startups, with flexible pricing for volume orders.
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Global logistics — Reliable shipping to North America, Europe, Asia, Australia, and the Middle East.
Contact & Order Information
Ready to incorporate SRBio Stephania Japonica Extract into your product line? Request a free sample, COA, or quotation today.
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Email: admin@plantextractssr.com
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Website: www.plantextractssr.com
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Phone: +8613720408392 (example – please replace with actual number)
For immediate assistance, please use the contact form on our website. We typically respond within 24 hours.
Shipping & Packing Information
OEM SERVICE
We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
