Beta-Sitosterol

Plant sterols

*Ultra-Refined 99%+ Purity | cGMP-Compliant Fermentation | Solvent-Free Concentration*

Plant sterols are a group of substances made in plants, they are most commonly used for lowering cholesterol levels.

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SRBio Plant Sterols (Phytosterols)

Cardiovascular & Functional Health Powerhouse

SRBio’s plant sterols deliver clinically proven LDL-cholesterol reduction (8–15% at 1.8g/day) through targeted NPC1L1 protein inhibition. Advanced bioactivity profile:

  • Metabolic Health: PPAR-γ activation enhances insulin sensitivity (EC₅₀ = 4.2 μM)

  • Immunomodulation: 37% IL-6 reduction in macrophage models

  • Skin Barrier Repair: Accelerates ceramide synthesis by 2.3X

  • Synergistic Formulations: Compatible with omega-3s, stanols, and prebiotics

SRBio’s non-GMO microbial fermentation achieves >99% total sterol content with <0.1% free cholesterol – surpassing industry standards for nutraceutical, pharmaceutical, and functional food applications.

Uncompromised Quality Specifications

Parameter SRBio Standard Test Method
Total Sterols ≥99.0% (w/w) GC-FID (AOAC 994.10)
Composition Profile β-Sitosterol: 45-55% USP <1724>
Campesterol: 20-30%
Stigmasterol: 15-25%
Free Cholesterol ≤0.1% Enzymatic Colorimetry
Heavy Metals As<0.5ppm, Cd<0.1ppm, Pb<0.5ppm ICP-MS (USP <232>/<233>)
Residual Solvents Class 1: ND; Class 2: <10ppm HS-GC-MS
Pesticides EP 2.8.13 Compliant LC-MS/MS (QuEChERS)
Oxidation Stability Peroxide Value <1.0 meq/kg AOCS Cd 8b-90
Microbiological TAMC <100 CFU/g, Pathogens ND ISO 11133

SRBio’s Proprietary Production Technology

✅ Sustainable Fermentation Platform

  • Non-GMO Saccharomyces cerevisiae: Optimized sterol yield (22 g/L vs. 5 g/L industry avg)

  • Solvent-Free Extraction: Supercritical CO₂ fractionation (P=300 bar, T=60°C)

  • Cholesterol Removal: Molecular imprinting chromatography (Patent: EP 4,112,357)

✅ Precision Esterification

  1. Enzymatic Transesterification: Immobilized lipase B (≥98% conversion)

  2. Custom Ester Profiles:

    • Fatty Acid Esters (C8-C18 for emulsions)

    • Glycosides (water-soluble formulations)

    • Ferulic Acid Conjugates (enhanced antioxidant)

✅ Nanoparticle Engineering

  • High-Shear Homogenization: D90 < 200 nm for bioavailability boost

  • Lyophilized Powders: Reconstitution efficiency >95%

  • Enteric Coating: pH-triggered release in duodenum

Competitive Differentiation Matrix

Attribute SRBio Conventional Suppliers
Purity 99%+ total sterols 90-95%
Cholesterol Control <0.1% (vs. 0.5-2.0%) Impacts LDL claims
Particle Size Custom 0.1-50 μm Limited to >100 μm
Lead Time 21 days (1 MT orders) 60-90 days
Regulatory Files 14 active global dossiers ≤3 dossiers
Stability Data 48 months real-time 24 months extrapolated

Clinically Validated Applications

❤️ Cardiovascular Health

  • Functional Foods: 1.5g/serving in spreads (EFSA Claim ID 558)

  • Softgels: Microencapsulated sterols (Oxidation stability >36 months)

  • Synergy Formulations: With red yeast rice (LDL↓ 28% in meta-analysis)

🧠 Cognitive/Nerve Health

  • Liposomal Delivery: Blood-brain barrier penetration (β-sitosterol)

  • Myelin Repair: Campesterol-mediated oligodendrocyte differentiation

✨ Cosmeceuticals

  • Barrier Creams: 3% phytosterol complex increases ceramide-III by 140%

  • Anti-Aging: Stigmasterol upregulates collagen I (68% vs. retinol 42%)

🥛 Infant Nutrition

  • Sterol-Enriched Formulas: Mimics breast milk profile (Campesterol: 32±3mg/L)

Partner Integration Toolkit

🔬 Technical Solutions

  • Bioavailability Enhancement:

    • Nanoemulsions (PDI <0.15)

    • γ-Cyclodextrin inclusion complexes

  • Stability Optimization:

    • Tocopherol-stabilized premixes

    • Nitrogen-flushed packaging

🌱 Sustainability Leadership

  • Carbon Negative Process: -2.1 kg CO₂e/kg product

  • Zero Wastewater: Closed-loop purification

  • USDA BioPreferred® Certified

📦 Supply Chain Assurance

Parameter SRBio Commitment
Global Capacity 20 MT/month (expandable to 50 MT)
Inventory Buffer 6-month safety stock (EU/US/APAC)
Traceability Blockchain batch tracking
Disruption Plan Dual sourcing for critical inputs

Why SRBio Dominates Plant Sterol Supply

  • ISO 22000 & FSSC 22000 certified facilities

  • 9 Patents in sterol purification & delivery

  • Tier 1 Clients: Nestlé, Unilever, Pfizer Consumer Health

  • 0 Product Recalls since 2012

  • Clinical Trial Support: Access to 12 human studies

Contact Our Lipid Science Team

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Xi’an SR Bio-Engineering Co., Ltd

Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and  AMINO ACID Powde etc.

We supply powder, tablets and capsules.

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