| Parameter | Specification |
|---|---|
| Chemical Name | D-chiro-Inositol |
| CAS Number | 643-12-9 |
| Molecular Formula | C₆H₁₂O₆ |
| Molecular Weight | 180.16 g/mol |
| Specification | ≥98.0% (HPLC); ≥99.0% customizable |
| Test Method | HPLC-RID, Polarimetry, ICP-MS (Heavy Metals) |
| Packaging | 25 kg/drum with double food-grade polyethylene liners; smaller sizes available |
| Key Properties | Naturally occurring inositol isomer, excellent water solubility, neutral taste, non-GMO |
| Application | Dietary supplements, functional foods, sports nutrition, women’s wellness formulations, metabolic health products |
Unlock the Potential of D-chiro-Inositol with SRBio’s High-Purity Production
SRBio D-chiro-Inositol (DCI) is a high-purity, bioidentical isomer of inositol, produced through advanced fermentation or controlled enzymatic conversion. As a key mediator of insulin signaling and cellular energy metabolism, DCI plays a critical role in maintaining metabolic balance and ovarian function. SRBio’s manufacturing platform ensures batch-to-batch consistency, exceptional purity, and a reliable supply chain—free from the variability of plant-derived sourcing.
Uncompromising Quality: SRBio’s Manufacturing Excellence
1. Precision Purity Control
| Parameter | SRBio Standard | Industry Typical | Test Method |
|---|---|---|---|
| Purity (HPLC) | ≥98.0% | 95.0% – 98.0% | HPLC-RID |
| Premium Grade Purity | ≥99.0% (Customizable) | Not Standard | HPLC-RID / Polarimetry |
| Optical Rotation ([α]²⁵/D) | +38.0° to +42.0° | Variable | Polarimetry |
| Loss on Drying | ≤1.0% | ≤2.0% | Karl Fischer |
| Heavy Metals (Total) | <10 ppm | ≤20 ppm | ICP-MS |
| Lead (Pb) | <0.5 ppm | ≤1.0 ppm | ICP-MS |
| Arsenic (As) | <0.5 ppm | ≤1.0 ppm | ICP-MS |
| Cadmium (Cd) | <0.1 ppm | ≤0.5 ppm | ICP-MS |
| Mercury (Hg) | <0.05 ppm | ≤0.1 ppm | ICP-MS |
| Residue on Ignition | ≤0.1% | ≤0.5% | USP <281> |
| Particle Size (D90) | ≤100 μm | Variable | Laser Diffraction |
2. Advanced Production Technology
Controlled Biosynthesis Platform
SRBio utilizes a proprietary fermentation process using non-GMO microbial strains optimized for high-yield DCI production. This approach eliminates the supply inconsistencies and purity variations associated with plant extraction (e.g., from carob or buckwheat), while ensuring a product free from pesticide residues and environmental contaminants.
Enzymatic Conversion (Optional)
For premium-grade DCI, SRBio employs a multi-enzymatic conversion process starting from myo-inositol, achieving >99% purity with precise stereochemical control. This method ensures the highest level of consistency and removes trace impurities commonly found in plant-sourced material.
Multi-Stage Purification
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Microfiltration: Removes cellular debris and high-molecular-weight impurities.
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Ion Exchange Chromatography: Eliminates ionic contaminants and achieves >99% purity.
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Controlled Crystallization: Optimized solvent system yields uniform crystalline particles with consistent polymorphic form.
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Low-Temperature Drying: Preserves the integrity of the molecule and ensures stability.
Exceptional Solubility & Stability
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Complete Solubility: ≥50 g/100 mL water at 25°C, forming a clear, stable solution.
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pH Stability: Stable across pH 2–10, suitable for a wide range of beverage and liquid formulations.
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Long-Term Stability: Retains ≥98% purity after 36 months when stored in a cool, dry environment (≤25°C, ≤60% RH), with no degradation products detected by HPLC.
Sensory Excellence
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Neutral Taste: No bitterness or aftertaste, ideal for flavored beverages, chewables, and functional foods.
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Non-Hygroscopic: Maintains free-flowing characteristics even under moderate humidity.
Scientific Basis & Functional Advantages
1. Role in Insulin Signaling Pathways
D-chiro-inositol is a key component of the inositol phosphoglycan (IPG) mediator, which acts as a second messenger in the insulin signaling cascade. It participates in the cellular response to insulin, supporting normal glucose metabolism and energy homeostasis.
2. Distinct but Complementary Role to Myo-Inositol
While myo-inositol is the most abundant form in the body, D-chiro-inositol serves distinct physiological functions. The two isomers work in a coordinated manner: myo-inositol is primarily involved in glucose uptake, while D-chiro-inositol is more directly linked to glycogen synthesis and downstream metabolic signaling. A balanced combination of both forms is often used in formulations targeting metabolic and hormonal health.
Comparative Properties:
| Property | D-chiro-Inositol | Myo-Inositol |
|---|---|---|
| Natural Abundance | <1% of total inositol pool | ~99% of total inositol pool |
| Primary Role | Insulin signaling, glycogen synthesis | Glucose transport, cell membrane function |
| Tissue Specificity | Ovarian, liver, muscle | Ubiquitous |
| Typical Ratio in Formulations | 1:40 to 1:20 (DCI:myo) | – |
3. Cellular Energy & Antioxidant Support
As a precursor for inositol phosphates involved in cellular signaling, DCI supports mitochondrial function and energy metabolism. It also contributes to the body’s antioxidant defense systems by participating in pathways that help neutralize reactive oxygen species.
4. Support for Ovarian & Hormonal Health
DCI is naturally concentrated in ovarian tissue and plays a role in supporting normal follicular development and hormonal balance. This has made it a valued ingredient in women’s wellness formulations, particularly those targeting metabolic and reproductive health.
Technical Specifications & Formulation-Ready Advantages
| Parameter | SRBio D-chiro-Inositol Standard | Test Method |
|---|---|---|
| Appearance | White to off-white, free-flowing crystalline powder | Visual Inspection |
| Purity (HPLC) | ≥98.0% (≥99.0% optional) | HPLC-RID |
| Optical Rotation | +38.0° to +42.0° | Polarimetry (USP <781>) |
| Loss on Drying | ≤1.0% | Karl Fischer (USP <921>) |
| Residue on Ignition | ≤0.1% | USP <281> |
| Solubility (25°C) | ≥50 g/100 mL water (clear solution) | Visual / Gravimetric |
| Bulk Density | 0.60 – 0.80 g/mL | USP <616> |
| Tapped Density | 0.80 – 1.00 g/mL | USP <616> |
| Particle Size (D90) | ≤100 μm (customizable) | Laser Diffraction |
| Heavy Metals (Total) | <10 ppm | ICP-MS |
| Lead (Pb) | <0.5 ppm | ICP-MS |
| Arsenic (As) | <0.5 ppm | ICP-MS |
| Cadmium (Cd) | <0.1 ppm | ICP-MS |
| Mercury (Hg) | <0.05 ppm | ICP-MS |
| Total Aerobic Microbial Count | ≤1,000 CFU/g | USP <61> |
| Total Yeast & Mold Count | ≤100 CFU/g | USP <61> |
| E. coli / Salmonella | Negative /25g | USP <62> |
Formulation-Ready Benefits by Application:
| Application | Key Advantage |
|---|---|
| Dietary Supplements (Capsules/Tablets) | Excellent flowability and compressibility; suitable for high-dose monographs; compatible with myo-inositol and other actives. |
| Functional Beverages | Complete solubility with no sedimentation; stable in acidic and neutral pH; neutral taste does not interfere with flavors. |
| Powdered Drink Mixes | Rapid dispersion; non-caking; maintains stability in single-serving sachets. |
| Chewable Tablets & Gummies | Neutral taste allows for pleasant flavor profiles; heat-stable for gummy manufacturing. |
| Sports Nutrition | Supports energy metabolism; easily incorporated into pre-workout and recovery formulas. |
| Women’s Wellness Formulations | Ideal for targeted blends with myo-inositol, folate, and other nutrients supporting hormonal balance. |
Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
Full Traceability: Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, optical rotation, heavy metals, microbiology, and physical properties. Complete production records from raw material to final product are available for qualified client audits.
Rapid Sampling: 50 g or 500 g R&D samples shipped within 72 hours with full COA + MSDS.
2. Global Regulatory Certifications
| Certification / Compliance | Status |
|---|---|
| ISO 22000 | Certified (all production sites) |
| Kosher & Halal | Certified |
| Non-GMO | Verified; produced from non-GMO raw materials |
| Allergen-Free Statement | Gluten-free, soy-free, dairy-free, egg-free, peanut-free (ELISA tested) |
| Vegan | No animal-derived ingredients used |
| US Dietary Supplement | NDI-ready dossiers available |
| EU Novel Food | Compliance documentation available (as appropriate) |
3. Supply Chain Resilience
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Redundant Manufacturing: Multiple fermentation lines and production sites ensure uninterrupted supply.
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Global Stock Hubs: Pre-positioned inventory in North America, Europe, and Asia for rapid fulfillment.
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Capacity: 5 MT/month standard, expandable to meet growing demand.
Competitive Breakdown: SRBio vs. Market Alternatives
| Capability | SRBio D-chiro-Inositol | Conventional Plant-Extracted DCI |
|---|---|---|
| Purity | ≥98.0% (≥99.0% optional) | 95.0% – 98.0%, often <97% |
| Batch-to-Batch Consistency | ±0.3% purity variance | ±2.0% or higher |
| Optical Rotation Control | Strictly maintained | Variable, often out of spec |
| Heavy Metals | <10 ppm total | ≤20 ppm or higher |
| Pesticide Residues | None detected | Variable risk from plant sourcing |
| Sourcing Consistency | Year-round, independent of harvest | Seasonal, supply chain dependent |
| Lead Time | 2–3 weeks (bulk orders) | 4–8 weeks, variable |
| Documentation | Full COA, traceability, regulatory dossiers | Limited or incomplete |
Technical Partnership Program
1. Co-Development Services
Formulation Support
Our applications lab can assist with stability testing, compatibility studies, and optimizing DCI levels in combination with myo-inositol, vitamins, and other bioactive ingredients.
Analytical Method Transfer
We provide validated HPLC and polarimetry methods for in-process and finished product quality control.
Custom Solutions
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Custom Ratios: Pre-mixed DCI:myo-inositol blends in ratios such as 1:20, 1:40, or custom formulations.
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Particle Size Optimization: Custom milling to meet specific requirements for direct compression or suspension.
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Packaging Options: Nitrogen-flushed foil bags, moisture-barrier drums, or branded private label packaging.
2. Market-Ready Solutions
Custom Premixes
| Blend Name | Composition | Target Application |
|---|---|---|
| Inositol Balance™ | DCI + Myo-Inositol (1:40 ratio) + Folate | Women’s wellness, hormonal balance |
| Metabolic Support Complex | DCI + Chromium + Berberine + Cinnamon | Metabolic health, glucose metabolism |
| Energy & Cellular Health | DCI + CoQ10 + Magnesium | Cellular energy, mitochondrial support |
| PCOS Wellness Formula | DCI + Myo-Inositol + Vitamin D3 + Zinc | Women’s reproductive and metabolic health |
Private Label Ready
Turnkey formulations available for:
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Capsules (250 mg, 500 mg, 750 mg DCI)
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Combination capsules (DCI + myo-inositol)
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Powder sticks (single-serving sachets)
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Chewable tablets
Partner with SRBio for High-Purity, Formulation-Ready D-chiro-Inositol
Ready to formulate with the industry’s most consistent, high-purity D-chiro-inositol? Request custom samples, technical dossiers, or discuss co-development opportunities for your next-generation women’s wellness, metabolic health, or functional food products.
→ Email: admin@plantextractssr.com
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We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
