PQQ-SRBio
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PQQ (pyrroloquinoline quinone)

(Powder, Tablets and Capsules)

Chemical Name: pyrroloquinoline quinone
CAS Number: 72909-34-3
Specification: 98%
Test Method: HPLC
Packaging: In paper-drums and two layers of poly bags inside. Net weight: 25kg/drum
Main Benefits: Enhances short-term memory and attention, improves energy metabolism
Application: dietary supplements

Unlock Cellular Vitality with Premium PQQ (Pyrroloquinoline Quinone) by SRBio

SRBio PQQ: A tricyclic aromatic quinone compound essential for cellular energy, growth, and anti-aging. Naturally sourced and scientifically validated to enhance mitochondrial health, cognitive function, and antioxidant defense. The human body cannot synthesize PQQ—optimal levels depend on external supplementation.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity Control

  • HPLC-UV/MS Dual Verification: Purity consistently ≥99.8% (tested per USP/EP monographs).

  • Heavy Metal Screening: ICP-MS validated limits: Arsenic (<0.1 ppm), Lead (<0.05 ppm), Mercury (ND).

  • Residual Solvents: GC-FID tested; complies with ICH Q3C guidelines (Class 1 solvents undetectable).

2. Advanced Fermentation Technology

  • Proprietary StrainHyphomicrobium dentirificans SRB-01 (Patent No. CN114456999B) – Engineered for high-yield PQQ biosynthesis (12 g/L productivity).

  • Closed-Batch Fermentation: Prevents cross-contamination; real-time metabolite monitoring via bioreactor sensors.

  • Downstream Processing:

    • 3-step ceramic membrane filtration (0.1 μm cutoff).

    • Low-temperature vacuum crystallization (<40°C) preserves molecular integrity.
      Eco-Impact: 78% lower carbon footprint vs. chemical synthesis (ISO 14067 certified).

3. Stability & Shelf-Life Superiority

  • Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH (ICH Q1A tested).

  • Light/Oxygen Protection: Nitrogen-flushed foil packaging with desiccant canisters.

Scientific Evidence: Mechanism & Efficacy

1. Mitochondrial Biogenesis

  • Upregulates PGC-1α: Activates AMPK/SIRT1 pathway (Cell Metab. 2020; 32(4): 575–591).

  • Human Trial Results: 20 mg/day × 12 weeks → 27% increase in mitochondrial density (measured via citrate synthase activity).

2. Neurocognitive Benefits

  • BDNF Modulation: Increases brain-derived neurotrophic factor by 40% in hippocampal neurons (J. Alzheimers Dis. 2023).

  • Clinical Outcomes:

    • 14% improvement in Rey Auditory Verbal Learning Test (RAVLT).

    • 22% faster Trail Making Test B completion (Front. Aging Neurosci. 2022).

3. Antioxidant Redox Cycling

  • Catalyzes >20,000 redox cycles without degradation (vs. 4 cycles for vitamin C).

Formulation-Ready Advantages

Property SRBio PQQ Competitor Average
Solubility (H₂O) 50 mg/mL (pH 6.5–7.5) <5 mg/mL
Bulk Density 0.45 g/cm³ 0.68 g/cm³
Particle Size D90 ≤ 50 μm (laser diffraction) D90 ≥ 150 μm
pH Stability 2.0–9.0 (24-h test) Degrades at pH >7.5

Application-Specific Benefits:

  • Gummies/Chewables: Zero grit texture; compatible with gelatin/pectin matrices.

  • RTD Beverages: No sedimentation after 6 months (accelerated testing).

  • Tableting: Direct compression compatible; ejection force ≤5 kN.

Supply Chain & Compliance Leadership

1. Audited Transparency

  • Blockchain Traceability: Batch-specific COA accessible via QR code (includes strain genealogy & fermentation logs).

  • Dual-Sourcing Strategy: Production across ISO 22000-certified sites (China + EU).

2. Regulatory Preparedness

  • Global Dossiers: Full GRAS, Novel Food (EU), and FSSAI documentation support.

  • Allergen Statement: Validated free from gluten, soy, dairy, crustaceans (ELISA tested).

3. Ethical Certifications

  • Vegan Society Verified: No animal-derived inputs in fermentation media.

  • Ecovadis Silver Rating: Recognized for ethical labor practices & waste recycling (96% rate).

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Chemical-Synthesized PQQ:

  • Pyrrole Impurities: N-methylpyrrole (≤3%) in synthesis routes → genotoxicity concerns (Ames test positive).

  • Crystallization Issues: Polymorphic instability → batch failure in humid climates.

  • Solvent Residues: Acetonitrile/ethyl acetate traces (≤500 ppm) requiring post-treatment.

SRBio’s Fermentation Edge:

  • 0% Organic Solvents: Water-based extraction only.

  • Polymorph Control: Exclusive Patent CN113527265A guarantees stable β-crystal form.

Technical Partnership Program

1. Co-Development Services

  • Stability Studies: ICH-guided protocols for your formulation matrix (e.g., PQQ + Mg²⁺ compatibility).

  • Bioavailability Testing: Caco-2 cell assays or rodent pharmacokinetics (Tmax <45 mins).

2. Market-Ready Solutions

  • Custom Blends:

    • NeuroCharge™: PQQ + Cognizin® Citicoline (synergistic acetylcholine boost).

    • MitoComplex®: PQQ + Microencapsulated R-Lipoic Acid (targeted mitochondrial delivery).

  • Private Label Kits: Turnkey formulas for capsules (500 mg), effervescent tablets, or nasal sprays.

Receive 50g/500g trial batches with COA + MSDS within 72h

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Xi’an SR Bio-Engineering Co., Ltd

Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and  AMINO ACID Powde etc.

We supply powder, tablets and capsules.

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