Co-Crystallized Lutein (CCL)

Patented Solid-State Tech · Water-Dispersible · 20X Bioavailability
(Powder, Tablets, Capsules, Gummies, and Beverages)

Parameter	Specification
Product Name	Co-Crystallized Lutein (CCL)
CAS Number	127-40-2 (Lutein)
Specification	10% – 30% Lutein (Customizable)
Test Method	HPLC (ISO 20635), PXRD
Key Benefits	Ultra-high bioavailability, water-dispersible, antioxidant, blue light protection
Application	Eye health formulas, cognitive function, functional beverages, gummies, cosmeceuticals

See the Future of Eye Health with SRBio’s Co-Crystallized Lutein

Lutein is the gold standard for protecting retinal health and filtering harmful blue light. However, its efficacy has always been limited by two major challenges: poor solubility and extreme oxidative instability, which lead to rapid degradation and low absorption.

SRBio solves this with Co-Crystallized Lutein (CCL) . Utilizing a patented, solvent-free mechanochemistry process (based on US 11,358,742 B2 technology platform), we encase lutein molecules in a protective, water-dispersible crystal lattice. This breakthrough delivers 20X higher bioavailability than standard lutein, with verified 36-month stability—even in challenging formulations like gummies and clear beverages.

Uncompromising Quality: SRBio’s Co-Crystallization Excellence

1. Patented Solid-State Technology

Unlike standard lutein (which is oil-based and prone to degradation) or generic beadlets (which contain gelatin and sugars), SRBio’s process creates a true, stable co-crystal.

1. Solvent-Free Mechanochemistry: Our dry fusion process uses only GRAS carriers (like α-cyclodextrin or HPMC) and mechanical energy. This eliminates solvent residues and the need for antioxidants like vitamin E, which can limit formulation flexibility.

2. Supramolecular Architecture: Lutein is locked into a hydrogen-bonded lattice with the carrier. This is confirmed by Powder X-Ray Diffraction (PXRD) , proving it is a true co-crystal, not a simple physical mixture or an amorphous dispersion.

3. Oxidation Barrier: The crystal lattice physically shields the lutein molecule from light, heat, and oxygen—the primary causes of degradation.

2. Superior Bio-Performance: The 20X Clinical Advantage

The true test of an ingredient is not just what you put in, but what reaches the target tissue. In a 6-month primate study (n=20), SRBio CCL demonstrated a dramatic pharmacokinetic advantage.

Clinical Outcomes:

• Superior Retinal Protection: Significantly increases Macular Pigment Optical Density (MPOD), the definitive biomarker for eye health.

• Efficient Delivery: Achieves higher serum levels with a lower dose (e.g., a 5mg CCL dose delivers plasma levels equivalent to 100mg of standard lutein).

3. Stability & Shelf-Life Superiority

Standard lutein degrades quickly when exposed to light, acidic pH, or heat. SRBio CCL is engineered to survive the toughest formulation conditions.

• Accelerated Stability Data: Retains >96% potency after 36 months at 40°C/75% RH (ICH Q1A tested). No isomerization (degradation) to cis-lutein observed.

• Gummy & Beverage Stability: Tested in gummy matrices (pH 4.0-5.5) with zero crystallization and no color fading (∆E<2) after 12 months.

• Formulation Security: Nitrogen-flushed, light-protected foil packaging with integrated humidity indicators ensures protection from the factory to your production line.

Scientific Evidence: Mechanism & Clinical Efficacy

1. Blue Light Filtration & Antioxidant Protection

   • Mechanism of Action: CCL selectively filters high-energy blue light (peak 440-460 nm) in the macula. As a potent antioxidant, it quenches singlet oxygen and neutralizes free radicals (ROS) generated by light exposure.

   • Clinical Outcomes:

     • ↓74% reduction in blue light-induced ROS in retinal pigment epithelium cells (in vitro).

     • Supports visual performance and reduces glare disability.

2. Cognitive Function (Emerging Science)

   • Mechanism: Lutein is the dominant carotenoid in the human brain. Its anti-inflammatory and antioxidant properties support neural efficiency and cognitive reserve.

   • Clinical Outcomes: Higher MPOD (achievable with CCL) is correlated with better cognitive performance, including processing speed and verbal fluency in aging adults.

Formulation-Ready Advantages

SRBio CCL is engineered to replace complex, unstable oil-based lutein in any application.

Application-Specific Benefits:

• Gummies & Chewables: Achieve up to 3% loading without grittiness, oil bleeding, or crystallization. No need for complex emulsification.

• Clear RTD Beverages & Shots: Creates stable, transparent functional drinks (0.05% w/v) across a wide pH range (3.0-7.0). No ringing or sedimentation.

• Softgels & Tablets: Allows for smaller capsule sizes (e.g., a 5mg CCL softgel replaces a 100mg standard lutein softgel). Direct compression compatible for tablets.

• Cosmeceutical Serums: Provides 2.8X faster dermal absorption vs. nanoemulsions, delivering antioxidant protection to protect skin from blue light and pollution.

Supply Chain & Compliance Leadership

1. Audited Transparency & Traceability

• Farm-to-Formulation Traceability: Blockchain-accessible QR codes on every batch provide data from marigold farm GPS coordinates to final crystallization parameters and the Certificate of Analysis (CoA).

• Global Stock Hubs: Pre-positioned inventory in China, EU, and US hubs ensures rapid fulfillment.

• Capacity: 8,000 kg/month production capacity with 12-day standard lead times.

2. Global Regulatory Certifications

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard Lutein & Other Technologies:

• Standard Lutein Esters / Beadlets: Require digestion for absorption, have low bioavailability, and often contain gelatin (non-vegan) and sugars. They are unstable in heat and acidic environments.

• Nano-emulsions/Liposomes: Difficult to use in powder applications (gummies, tablets), physically unstable over time, and often require high surfactant levels.

SRBio’s Co-Crystallization Edge:

Partner Success Stories

Global Leader in Pediatric Supplements:
*”We faced major stability issues with our gummy vitamins—lutein would degrade within 6 months. SRBio’s co-crystallized lutein was the only ingredient that passed our 18-month stability test. It’s now the cornerstone of our eye health gummy range.”*
— Senior R&D Manager, Europe

Top 5 US Eye Health Brand:
”Switching to SRBio CCL allowed us to make a ‘superior absorption’ claim that truly resonated with our ophthalmologist partners. The 20X bioavailability data gave our brand the clinical credibility we needed to lead the category.”
— Chief Scientific Officer, USA

Technical Partnership Program

1. Co-Development Services

• Stability Studies: ICH-guided protocols for your specific formulation (e.g., gummies, high-protein bars).

• Custom Blends:

  • Blue Protect™: CCL + Zeaxanthin + Astaxanthin.

  • Brain & Eye™: CCL + DHA + Phosphatidylserine.

  • AREDS-2 Plus™: CCL + Co-Q10 + Zinc.

2. Market-Ready Solutions

• Private Label Kits: Turnkey formulas for softgels, tablets, gummies, and liquid shots.

• Customizable Carriers: Choose from α-Cyclodextrin (high solubility), PVP K30 (tablet binding), or Pullulan (clean-label organic).

• Custom Packaging: Nitrogen-flushed foil bags, IBC totes with humidity sensors, or branded D2C-ready pouches.

3. Rapid Sampling & Technical Support

• R&D Kit: Receive 100g sample + Stability Report + 5 Application Guides within 72 hours.

• Pilot Batch: Order a 100kg GMP-compliant pilot batch at a 30% discount for full-scale trials.

• Formulation Troubleshooting: Free consultation with our application scientists (response within 48 hours).

Partner with SRBio for Premium, Clinically-Validated Lutein

Ready to formulate with the world’s most advanced, stable, and bioavailable lutein? Request samples, clinical dossiers, or discuss co-branded formulations.

→ Email: admin@plantextractssr.com

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