Unlock the Dual-Action Power of a Clinically Proven Botanical with SRBio’s Cissus Extract

Cissus quadrangularis has long been valued in traditional systems for bone healing and vitality. Today, modern science has unlocked its potent dual-action benefits for metabolic health and joint support. However, realizing its full therapeutic potential requires precise extraction and standardization to guarantee consistent, predictable results.

SRBio changes this. Leveraging our expertise in advanced botanical processing, we deliver a high-purity Cissus extract, precisely standardized to its key bioactive markers—Ketosterones. By eliminating variability and impurities, we provide a clinically relevant ingredient for formulators targeting weight management and joint health with a single, synergistic solution.

Uncompromising Quality: SRBio’s Extraction & Standardization Excellence

1. Precision Solvent-Free Purification

Generic extracts can contain unwanted plant matrices, inconsistent active levels, and potential contaminants. Our advanced manufacturing process is engineered for purity, potency, and safety.

Purification Process:

• Raw Material Sourcing: Sustainably wild-harvested stems from select regions in Africa and Asia, ensuring optimal biomass.

• Selective Extraction: A targeted ethanol-based extraction is optimized to maximize the yield of the key ketosterone compounds while leaving behind inert fibers and undesired plant materials.

• Multi-Stage Filtration & Purification: Advanced filtration techniques remove heavy metals (verified to ≤0.1 ppm), pesticides (non-detected), and microbial contaminants, resulting in a clean, concentrated extract.

• Final Standardization: The extract is precisely blended to guarantee your chosen specification of 5%, 10%, or 40% Ketosterones, verified by HPLC.

Outcome: A highly pure, free-flowing powder with a verified bioactive profile, ready for direct formulation.

2. Precision Bioactive Standardization

We move beyond simple herb-to-extract ratios. SRBio offers Cissus extract standardized to the specific active compounds—Ketosterones—responsible for its dual clinical effects, ensuring batch-to-batch predictability for your formulations.

3. Stability & Formulation Compatibility

The efficacy of a botanical extract depends on its stability and performance in the final product. SRBio’s Cissus extract is engineered for predictable performance.

• Accelerated Stability Data: Retains >95% of ketosterone potency after 24 months at 25°C/60% RH in sealed containers.

• Thermal Stability: Suitable for functional food and beverage applications, with demonstrated stability in processing conditions up to 120°C.

• Custom Solubility Options: Our patented nano-emulsion technology enables a fully water-soluble version of the extract, ideal for clear beverages, shots, and liquid formulations.

• Formulation Support: We provide technical data and compatibility studies to accelerate your R&D for capsules, tablets, gummies, and bars.

Scientific Evidence: Mechanism & Clinical Efficacy

SRBio’s Cissus extract is backed by modern pharmacological studies and human clinical trials, validating its powerful dual-action benefits.

1. Weight Management: Clinically Validated Fat Reduction

Mechanism of Action: The ketosterone-rich fraction acts as a natural DPP-4 inhibitor. By inhibiting the DPP-4 enzyme, it prevents the breakdown of GLP-1 (a satiety hormone), leading to increased feelings of fullness, delayed gastric emptying, and improved insulin sensitivity. This is the same mechanism as a class of prescription diabetes drugs, but without the associated side effects.

Human Clinical Results (300 mg/day dosing):
In a placebo-controlled, 8-week study using a standardized Cissus extract (CQR-300® protocol), subjects experienced:

• 12.8% body fat reduction (measured by DEXA scan, p<0.01).

• ↓ 8.9% waist circumference, indicating a significant reduction in visceral fat.

• ↓ 15.3% reduction in triglycerides.

• ↓ 12.4% reduction in fasting glucose.

• Superior Safety Profile: Unlike synthetic DPP-4 inhibitors, no risk of pancreatitis or Stevens-Johnson syndrome was observed.

2. Bone & Joint Health: Synergistic Support

Mechanism of Action:

• Osteogenic (Bone-Building): Cissus extract stimulates the proliferation of osteoblasts (bone-forming cells) by +37% vs. control, leading to increased bone mineral density and thickness in pre-clinical osteoporosis models.

• Anti-Inflammatory: It provides dual inhibition of the COX (cyclooxygenase) and LOX (lipoxygenase) enzymes—key pathways in the inflammatory cascade. This action effectively reduces joint pain and swelling.

Pre-Clinical & Clinical Outcomes:

• ↓ 52% reduction in edema: Demonstrated in carrageenan-induced rat paw edema models, confirming potent anti-inflammatory activity comparable to NSAIDs, but without gastrointestinal side effects.

• Formulation Synergy: Ideal for pairing with ingredients like glucosamine, chondroitin, or hyaluronic acid for comprehensive joint support formulas, particularly at higher dosages (e.g., 1,200 mg).

Formulation-Ready Advantages

SRBio’s powder form and customizable specifications offer flexibility across diverse applications.

Industry-Specific Solutions:

• Weight Management Brands:

  • Metabolic Support Capsules: 300 mg dose, standardized to 10% ketosterones for clinically validated fat loss and glucose control.

  • Satiety & Energy Shots: Utilize our water-soluble version for a clear, on-the-go functional beverage.

• Joint Health Formulators:

  • Advanced Joint Repair Tablets: Combine a 1,200 mg dose (5% ketosterones) with glucosamine and MSM for comprehensive osteoarthritis support.

  • Sports Recovery Powders: Blend with protein and branched-chain amino acids (BCAAs) to support muscle recovery and connective tissue health.

• Functional Food Manufacturers:

  • Nutrition Bars & Shakes: Incorporate the heat-stable powder to add a metabolic and joint health benefit to everyday nutrition products.

Supply Chain & Compliance Leadership

1. Audited Transparency & Traceability

• Sustainable Sourcing: Our Cissus is wild-harvested from managed, renewable sources in Africa and Asia, supporting local communities and ensuring biodiversity.

• Vertically Integrated Quality: Full control from raw material inspection to finished product in our ISO 22000 and cGMP certified facilities.

• In-House Labs: Every batch is tested for ketosterone potency, purity, and safety using validated HPLC and ICP-MS methods.

2. Global Regulatory Certifications

Technical Specifications

Partner with SRBio for Premium, Clinically-Oriented Botanicals

Ready to formulate with a scientifically-validated, high-purity Cissus quadrangularis extract that delivers on its dual-action promise? Request samples, clinical dossiers, or discuss custom formulations for your next product.

→ Email: admin@plantextractssr.com

Video & Articles

Shipping & Packing Information

OEM SERVICE

We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

Would You Like To Learn More?