L-5-Methyltetrahydrofolate Glucosamine Salt Manufacturer & Supplier
CAS No.: 1181972-37-1
Molecular Formula: C32H51N9O16
Grade: Pharmaceutical / Nutra Grade (4th Generation Folate)
Synonyms: 5-MTHF Glucosamine; (6S)-5-Methyltetrahydrofolic acid glucosamine salt
1. Product Overview
L-5-Methyltetrahydrofolate (L-5-MTHF) Glucosamine Salt is the most advanced, highly stable, and bioavailable form of folate currently available on the global market. Often referred to as the “Body-Ready Folate,” it bypasses the entire complex metabolic pathway required by synthetic folic acid.
Unlike 1st and 2nd generation folates, our 4th Generation Glucosamine Salt form ensures that even individuals with the MTHFR genetic polymorphism can effectively utilize this essential nutrient. At Xi’an SR Bio-Engineering, we utilize a patented-standard crystallization process to ensure a high-purity, stable powder that meets the rigorous demands of premium pharmaceutical and nutraceutical brands.
2. Technical Comparison: Why 4th Gen is Superior
Choosing the right folate is critical for product efficacy. The table below highlights why Glucosamine Salt is replacing traditional Calcium salts:
| Technical Feature | Folic Acid (2nd Gen) | 5-MTHF Calcium (3rd Gen) | 5-MTHF Glucosamine (4th Gen) |
| Metabolic Step | Requires 4-step conversion | Immediate use | Immediate use |
| Water Solubility | Very Poor | Limited | 100x Higher than Calcium Salt |
| Bioavailability | Variable (Genetics dependent) | High | Superior (Peak Blood Levels) |
| Stability | High | Heat/Moisture Sensitive | Significantly Improved |
| Application | Basic fortification | Capsules/Tablets | Ideal for Liquids & Premium Solids |
3. Deep-Dive: Science & Mechanism
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The MTHFR Solution: Approximately 40-60% of the global population has a genetic mutation (MTHFR) that impairs their ability to convert folic acid into its active form. L-5-MTHF Glucosamine Salt provides the active metabolite directly, ensuring clinical efficacy for all users.
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Glucosamine as a Stabilizer: In this 4th generation form, glucosamine is not just an “active ingredient” but acts as a stabilizing counter-ion that prevents the folate molecule from degrading, ensuring a longer shelf life for your finished products.
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Homocysteine Regulation: It serves as a primary methyl donor in the conversion of homocysteine to methionine, a critical process for cardiovascular and neurological health.
4. Technical Specifications (COA)
| Test Item | Specification Standard | Actual Result |
| Appearance | White to light yellow crystalline powder | Conforms |
| Assay (L-5-MTHF) | 54.0% – 59.0% | 56.5% |
| Total Assay (as Salt) | 98.0% – 102.0% | 99.8% |
| Specific Rotation | +40.0° to +48.0° | +44.5° |
| Water Content (KF) | ≤ 8.0% | 4.5% |
| Total Heavy Metals | ≤ 10 ppm | < 2 ppm |
| Lead (Pb) | ≤ 1.0 ppm | < 0.2 ppm |
| Mercury (Hg) | ≤ 0.1 ppm | < 0.01 ppm |
| Microbial Count | Total Plate Count < 1000cfu/g | Conforms |
5. End-to-End OEM and ODM Partnership
As a specialized B2B partner, Xi’an SR Bio-Engineering helps you navigate the complexities of formulating with high-value methylfolates.
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Synergistic Formulation Design:
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Prenatal Care: 5-MTHF + Iron Bisglycinate + DHA.
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Cognitive Support: 5-MTHF + Methylcobalamin (B12) + P-5-P (B6).
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Cardiovascular Health: 5-MTHF + CoQ10 + Garlic Extract.
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Advanced Dosage Forms:
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Micro-Tablets: Small-diameter tablets for easy compliance.
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Sublingual Drops: Utilizing its superior solubility for mucosal absorption.
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Powder Sticks: Stable, great-tasting instant drink mixes.
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Regulatory & Compliance Package: We provide comprehensive documentation for international market entry, including stability data at various temperatures and humidity levels.
6. Manufacturing Advantages
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Superior Solubility: Dissolves rapidly in water, which is essential for liquid supplements where clarity and sediment-free formulas are required.
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Non-Hygroscopic Nature: Our specific crystalline form is less prone to clumping, making it easier to handle in high-speed automated encapsulation machines.
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Sustainability: Produced using green chemistry principles, minimizing solvent waste.
7. Packaging & Logistics
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Standard Packing: 1kg/Aluminum foil bag (Vacuum sealed), 25kg/Fiber Drum.
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MOQ: 1kg (Tailored for R&D trials and specialized high-potency projects).
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Storage Conditions: Store in a cool, dry place ($2-8^{\circ}\text{C}$ recommended for bulk storage). Keep away from strong light and heat.
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Global Shipping: Door-to-door delivery via FedEx/DHL or Air/Sea freight for bulk orders.
Shipping & Packing Information
OEM SERVICE
We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
