Chemical Name	L-Arginine α-ketoglutarate (1:1 or 2:1 salt)
CAS Number	16856-18-1 / 5256-65-5 (depending on ratio)
Molecular Formula	C₁₁H₂₂N₄O₇ (for 1:1 salt, example)
Specification	98.0% – 101.0% (HPLC)
Test Method	HPLC (for Arginine & AKG), Titration
Packaging	In paper-drums with double polyethylene bags inside. Net weight: 25kg/drum
Main Benefits	Enhances nitric oxide (NO) production, supports muscle pump, improves endurance, aids recovery
Application	Sports nutrition, dietary supplements, pre-workout formulas, clinical nutrition

The Premier Nitric Oxide Generator: Premium AAKG (Arginine Alpha-Ketoglutarate) by SRBio

SRBio AAKG (Arginine Alpha-Ketoglutarate) is the synergistic salt of the conditionally essential amino acid L-Arginine and the Krebs cycle intermediate Alpha-Ketoglutarate. This unique compound is a cornerstone of the sports nutrition industry, prized for its ability to enhance nitric oxide (NO) synthesis, leading to improved vasodilation, increased blood flow, and superior muscle pump. Beyond athletic performance, it supports wound healing, immune function, and overall metabolic health.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity & Composition Control

   • Guaranteed Potency & Ratio: Our production process ensures a consistent and precise molar ratio of Arginine to Alpha-Ketoglutarate (typically 2:1 or 1:1). HPLC-UV/RI dual detection confirms purity ≥98.5%, free from unreacted amino acids or by-products.

   • Heavy Metal Screening: ICP-MS validated limits: Arsenic (<0.5 ppm), Lead (<0.1 ppm), Cadmium (<0.05 ppm), Mercury (ND). Compliant with global supplement standards.

   • Residual Solvents: GC-FID tested; confirms absence of organic solvents, as our synthesis is water-based.

2. Advanced Synthesis Technology

   • Controlled Salt Formation: Our process reacts high-purity L-Arginine (from fermentation) with food-grade Alpha-Ketoglutaric acid under precisely controlled conditions. This ensures complete and stable salt formation, not a simple physical mixture.

   • Multi-Stage Purification & Crystallization: The resulting salt is purified through multiple crystallization steps, removing impurities and ensuring a consistent, free-flowing crystalline powder with excellent stability.

   • Low-Impact Drying: Gentle drying technology preserves the integrity of both components, preventing degradation or discoloration.

3. Stability & Shelf-Life Superiority

   • Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH (ICH Q1A tested). No significant change in appearance or solubility.

   • Hygroscopicity Control: Engineered for low moisture absorption, ensuring excellent flowability and preventing clumping during storage and high-speed manufacturing.

   • Light/Oxygen Protection: Nitrogen-flushed, moisture-barrier foil packaging with desiccant guarantees stability from factory to formulation.

Scientific Evidence: Mechanism & Efficacy

1. Nitric Oxide (NO) Boosting & Vasodilation

   • L-Arginine as NO Precursor: L-Arginine is the sole physiological substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide. NO relaxes blood vessels, improving blood flow, nutrient delivery, and oxygen transport to muscles. *[Reference: J Nutr. 2021; 151(9): 2567-2578]*

   • Enhanced Uptake: Binding Arginine to Alpha-Ketoglutarate is believed to improve its stability and absorption, reducing first-pass metabolism in the gut and making more Arginine available for NO synthesis.

2. Synergistic Role in Energy Metabolism

   • Alpha-Ketoglutarate (AKG) in the Krebs Cycle: AKG is a key intermediate in the citric acid (Krebs) cycle, playing a central role in cellular energy (ATP) production. It also serves as a precursor for glutamate and glutamine.

   • Glutamine Synthesis: AKG fuels the production of glutamine, an amino acid critical for immune cell function and muscle recovery.

3. Clinical & Performance Outcomes

   • Enhanced Exercise Performance: Multiple studies suggest AAKG supplementation can increase time to exhaustion, improve power output, and reduce perceived fatigue during resistance and endurance training.

   • Muscle Protein Synthesis: By improving blood flow and providing precursors for metabolic pathways, AAKG supports an anabolic environment conducive to muscle growth and repair.

   • Recovery & Wound Healing: Supports tissue regeneration and collagen synthesis, aiding in post-exercise recovery and general wound healing processes.

Formulation-Ready Advantages

Application-Specific Benefits:

• Pre-Workout Powders: High solubility ensures rapid dissolution in shaker bottles with no grit. Consistent particle size prevents segregation in complex blends.

• Capsules & Tablets: Good flow and compressibility allow for uniform filling and consistent tablet weight. Can be used in high-dose formulations.

• Ready-to-Drink (RTD) Beverages: Excellent stability in liquid formulations; maintains potency and clarity over shelf-life.

Supply Chain & Compliance Leadership

1. Audited Transparency

   • Full Traceability: Batch-specific Certificates of Analysis (COA) with complete purity, heavy metal, and microbial data are always available.

   • Production Capacity: Multiple production lines across ISO 9001 and GMP-certified facilities ensure consistent supply for projects of any scale.

2. Regulatory Preparedness

   • Global Compliance: Meets USP/EP standards for related substances. Full documentation for regulatory filings worldwide available.

   • Allergen Statement: Validated free from gluten, soy, dairy, nuts, and crustaceans (ELISA tested). Produced in dedicated allergen-managed facilities.

3. Ethical Certifications

   • Kosher & Halal Certified: Available upon request.

   • Non-GMO & Vegan: Sourcing and production processes ensure a final product suitable for all dietary preferences.

   • Ecovadis Recognition: Committed to ethical labor practices and sustainable manufacturing.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard AAKG:

• Inconsistent Ratio: Variable ratios of Arginine to AKG lead to unpredictable efficacy and dosing.

• Poor Solubility & Flow: Clumping and slow dissolution rates cause formulation headaches and poor user experience.

• Off-Flavors: Degradation products or impurities result in bitter or unpleasant tastes, requiring heavy masking.

• High Hygroscopicity: Absorbs moisture rapidly, causing caking and loss of potency.

SRBio’s Manufacturing Edge:

• Guaranteed Stoichiometry: Consistent 2:1 (or 1:1) molar ratio, ensuring reliable performance.

• Optimized Solubility & Flow: Engineered for rapid dissolution and smooth manufacturing.

• Consistent Organoleptics: High purity ensures a predictable, manageable taste profile.

Technical Partnership Program

1. Co-Development Services

   • Custom Blends: Synergistic combinations with Citrulline, Beta-Alanine, Creatine, or BCAAs for comprehensive pre-workout or recovery formulas.

   • Formulation Support: Our lab can assist with stability studies, solubility testing, and taste-masking strategies.

2. Market-Ready Solutions

   • Private Label Kits: Turnkey formulas for pre-workout powders, capsules, or tablets containing AAKG for rapid market entry.

Receive 1kg/5kg trial batches with COA + MSDS within 72 hours

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Shipping & Packing Information

OEM SERVICE

We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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