Chemical Name:	Alpha-Ketoglutaric Acid / 2-Oxoglutaric Acid
CAS Number:	328-50-7 / 16824-23-0 (for Arginine-AKG)
Specification:	98.0% – 101.0% (AKG) / 99% (AAKG)
Test Method:	Titration / HPLC
Packaging:	In fiber drums with double food-grade PE bags inside. Net weight: 25kg/drum.
Main Benefits:	Supports protein synthesis, enhances nitric oxide production, promotes muscle recovery, and supports metabolic health.
Application:	Sports nutrition, dietary supplements, healthy aging formulations.

Elevate Performance & Vitality with Premium AKG by SRBio

SRBio AKG (Alpha-Ketoglutarate) and its highly bioavailable form, Arginine AKG (AAKG), are fundamental intermediates in the Krebs cycle, essential for cellular energy production, ammonia detoxification, and protein metabolism. As we age, endogenous AKG levels decline. SRBio provides pharma-grade AKG, scientifically validated to support muscle function, enhance nitric oxide (NO) pathways, and promote healthy aging, ensuring your formulations deliver peak performance.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity Control

   • High-Purity Verification: Titration and HPLC-UV validated purity consistently meets or exceeds 99.0% (USP/EP compliance).

   • Heavy Metal Screening: ICP-MS analysis guarantees limits: Arsenic (<1.0 ppm), Lead (<0.5 ppm), Cadmium (<0.5 ppm), Mercury (<0.1 ppm).

   • Residual Solvents: GC-FID testing fully complies with ICH Q3C guidelines, ensuring Class 1 and 2 solvents are absent.

2. Advanced & Sustainable Synthesis

   • Proprietary Fermentation & Purification: Utilizing optimized microbial strains (e.g., Corynebacterium glutamicum) for high-yield, food-grade production. This ensures a non-animal-derived product with superior consistency.

   • Closed-Loop Processing: State-of-the-art bioreactors with real-time monitoring (pH, DO, nutrient levels) for batch-to-batch reproducibility.

   • Green Purification Technology:

     • Multi-stage membrane filtration and activated carbon treatment.

     • Low-temperature vacuum crystallization (<50°C) to preserve molecular integrity and prevent formation of process-related impurities.

   • Eco-Impact: Our biological route reduces energy consumption by approximately 65% compared to traditional chemical synthesis (internal audit data).

3. Stability & Shelf-Life Superiority

   • Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH in sealed, original packaging (ICH Q1A guidelines).

   • Advanced Protection: Packaged with oxygen absorbers and desiccant in nitrogen-flushed, moisture-barrier foil bags to prevent caking and degradation during storage and transport.

Scientific Evidence: Mechanism & Efficacy

1. Muscle Protein Synthesis & Anti-Catabolism

   • mTOR Pathway Activation: AKG acts as a key nitrogen shuttle, promoting leucine uptake and activating the mTOR signaling pathway, crucial for muscle protein synthesis (Cell Metab. 2016).

   • Ammonia Scavenging: In the muscle, AKG combines with toxic ammonia (generated during intense exercise) to form glutamate and glutamine, effectively reducing exercise-induced fatigue and supporting faster recovery.

2. Vasodilation & Nitric Oxide (NO) Boosting (AAKG)

   • Sustained NO Production: Arginine Alpha-Ketoglutarate (AAKG) delivers L-Arginine in a highly stable form, serving as a direct precursor for nitric oxide (NO) synthesis.

   • Clinical Outcome: Enhanced NO production leads to significant vasodilation, increasing blood flow, nutrient delivery, and the “muscle pump” effect, as demonstrated in studies showing improved performance in resistance training (J. Int. Soc. Sports Nutr.).

3. Healthy Aging & Metabolic Support

   • Epigenetic Regulation: Emerging research indicates AKG extends lifespan in model organisms by inhibiting ATP synthase and acting as a co-substrate for enzymes that regulate aging (Nature 2020).

   • Collagen Synthesis: As a critical cofactor for prolyl hydroxylase enzymes, AKG is essential for stable collagen synthesis, supporting joint, skin, and bone health.

Formulation-Ready Advantages

Application-Specific Benefits:

• Pre-Workout Powders: Superior solubility and neutral taste profile minimizes flavor-masking challenges.

• Capsules/Tablets: Excellent compressibility and flow characteristics enable high-dose formulations without large tablet sizes.

• Ready-to-Drink (RTD): Formulation-grade AAKG remains stable in solution with no precipitation over accelerated shelf-life testing (6 months).

Supply Chain & Compliance Leadership

1. Audited Transparency

   • Full Traceability: Batch-specific Certificate of Analysis (COA) includes full impurity profile and manufacturing date.

   • Secure Sourcing: Dual-sourcing strategy for raw materials ensures supply chain resilience from ISO 22000-certified facilities.

2. Regulatory Preparedness

   • Global Compliance: Full documentation support for GRAS (USA), Novel Food (EU), and Health Canada applications.

   • Allergen-Free: Validated to be free from gluten, soy, dairy, egg, peanuts, and crustaceans (ELISA tested).

3. Ethical Certifications

   • Non-GMO & Vegan: Verified production process with no animal-derived inputs and non-GMO microbial strains.

   • ISO 14001: Environmental management certified, reflecting our commitment to sustainable manufacturing.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Low-Grade AKG:

• High Biuret Content: Impurities from poor synthesis can cause gastrointestinal distress.

• Inconsistent Particle Size: Leads to poor blending and content uniformity in final products.

• Moisture Instability: Prone to caking and degradation, especially in humid climates.

SRBio’s Quality Edge:

• Zero Biuret: Our advanced fermentation and purification process eliminates biuret and other process-related impurities common in cheaper chemical synthesis.

• Controlled Crystallization: Proprietary technology ensures consistent crystal morphology for superior stability and flow.

• Lot-to-Lot Consistency: Every batch is QC/QA released against a retained reference standard, guaranteeing the same high performance every time.

Technical Partnership Program

1. Co-Development Services

   • Formulation Support: Our lab can assist with stability studies for your specific matrix (e.g., AKG in effervescent tablets with citric acid).

   • Analytical Method Transfer: We provide full HPLC methods for accurate quantification in your finished products.

2. Market-Ready Solutions

   • Custom Blends:

     • VasoPump™: AAKG + Nitrosigine® for immediate and extended-release NO support.

     • RecoverMAX®: AKG + L-Glutamine + BCAA for post-workout synergy.

   • Private Label Kits: Ready-to-market formulas for capsules (750mg, 1000mg), powders (lemonade flavor), and tablets.

Receive 50g/500g trial batches with full COA + MSDS within 72 hours. Contact our technical sales team to discuss your project.

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We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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