Latin Name	Andrographis paniculata (Burm. f.) Nees
Part Used	Leaf
Active Ingredient	Andrographolide
CAS Number	5508-58-7
Specification	Andrographolide 10% – 99% (HPLC); 10:1 Extract
Test Method	HPLC (for Andrographolide) / TLC
Appearance	Fine Yellow Powder
Certifications	HALAL, KOSHER, ISO22000, SC, BRC (ORGANIC)
Packaging	1kg/bag (foil), 25kg/drum, or customized formulation
Main Benefits	Supports immune health, maintains respiratory function, provides anti-inflammatory support
Application	Dietary supplements, pharmaceuticals, veterinary medicine, functional foods

Unlock Nature’s Defense: Premium Andrographis Paniculata Extract by SRBio

SRBio Andrographis Extract is derived from the esteemed medicinal plant Andrographis paniculata, traditionally used in Ayurveda and Traditional Chinese Medicine. Our standardized extraction process guarantees precise levels of the key bioactive compound, Andrographolide, a labdane diterpenoid renowned for its potent immunomodulatory and anti-inflammatory properties. Ideal for formulators seeking a scientifically-validated ingredient to support immune health and overall wellness.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Precision Purity & Potency Control

   • Standardized Andrographolide Content: Guaranteed potency from 10% to 99% (HPLC-UV validated), ensuring batch-to-batch consistency for reliable formulation.

   • Full Spectrum Analysis: Beyond andrographolide, we can provide chromatographic fingerprints to confirm the presence of other synergistic compounds like deoxyandrographolide and neoandrographolide, ensuring authenticity.

   • Heavy Metal Screening: ICP-MS validated limits: Arsenic (<0.5 ppm), Lead (<0.1 ppm), Cadmium (<0.05 ppm), Mercury (ND).

   • Pesticide Residues: Comprehensive multi-residue screening (GC-MS/MS) confirms compliance with EU and USP pharmacopoeial standards (all below detection limits).

2. Advanced Extraction Technology

   • Controlled Extraction Process: Utilizes a validated ethanol/water extraction method optimized to maximize the yield of andrographolide and related diterpene lactones while preserving their molecular integrity.

   • Multi-Stage Purification: Employs a series of membrane filtration, concentration, and selective adsorption chromatography steps to remove unwanted plant materials, waxes, and chlorophyll, resulting in a pure, consistent yellow powder.

   • Low-Temperature Spray Drying: Gentle drying technology (<80°C inlet temperature) prevents thermal degradation of heat-sensitive andrographolides, ensuring maximum bioactivity.

   • Solvent Control: Residual solvents are strictly monitored via GC-FID, consistently below ICH Q3C limits (ethanol < 5000 ppm).

3. Stability & Shelf-Life Superiority

   • Accelerated Stability Data: Retains ≥95% of labeled andrographolide content after 24 months when stored in cool, dry conditions (25°C/60% RH), as per ICH Q1A guidelines.

   • Hygroscopicity Control: Engineered for low moisture absorption (<5%), ensuring excellent flowability and preventing clumping during storage and formulation.

   • Light/Oxygen Protection: Nitrogen-flushed, airtight foil packaging with desiccant ensures stability from factory to your production line.

Scientific Evidence: Mechanism & Efficacy

1. Immunomodulatory Action

   • Innate Immune Response: Andrographolide has been shown to modulate key signaling pathways (e.g., NF-κB), helping to balance the body’s immune response without overstimulation. [Reference: Phytomedicine. 2021; 91: 153698]

   • Adaptive Immunity: Studies indicate it can influence T-cell and B-cell activity, supporting a comprehensive and balanced immune defense.

2. Respiratory Health Support

   • Upper Respiratory Tract: Clinical research suggests that standardized Andrographis paniculata extract can help reduce the severity and duration of common upper respiratory tract infections. *[Reference: Planta Med. 2019; 85(3): 179-187]*

   • Inflammatory Modulation: Its anti-inflammatory properties help soothe irritated mucous membranes in the throat and respiratory passages.

3. Antioxidant & Hepatoprotective Potential

   • Free Radical Scavenging: Demonstrates significant free radical scavenging activity, contributing to the body’s overall antioxidant defense network.

   • Liver Support: Preclinical studies suggest andrographolide may support liver health by promoting healthy enzyme levels and protecting against oxidative stress.

Formulation-Ready Advantages

Application-Specific Benefits:

• Capsules & Tablets: Excellent flow properties ensure uniform filling and consistent tablet weight. The fine, standardized particle size allows for homogeneous blending with other actives.

• Liquid Extracts & Tinctures: Our extracts are an ideal base for creating standardized liquid preparations with consistent potency and solubility.

• Functional Foods: The characteristic bitterness can be managed in formulations aimed at wellness shots, teas, or functional gummies for immune support.

Supply Chain & Compliance Leadership

1. Audited Transparency & Sourcing

   • Botanical Identity: Each batch is accompanied by macroscopic and microscopic authentication of the raw herb, verified by our in-house pharmacognosy experts.

   • Traceability: Full documentation from cultivated herb source to finished extract. Batch-specific Certificates of Analysis (COA) with full chromatographic data are always available.

   • Sustainable Sourcing: We partner with GACP-compliant farms, ensuring sustainable cultivation and fair labor practices.

2. Regulatory Preparedness

   • Global Dossiers: Comprehensive technical dossiers available to support regulatory filings for dietary supplements and pharmaceuticals worldwide.

   • Allergen Statement: Validated free from gluten, soy, dairy, nuts, and crustaceans (ELISA tested). Produced in allergen-managed facilities.

   • Organic & Conventional: Available in both certified organic and high-quality conventional grades to meet diverse market needs.

3. Ethical Certifications

   • HALAL & KOSHER Certified: Available upon request.

   • Non-GMO & Vegan: Production processes ensure a non-GMO final product suitable for vegan formulations.

Competitive Breakdown: SRBio vs. Market Alternatives

Key Deficiencies in Standard Andrographis Extracts:

• Inconsistent Potency: Wide variations in andrographolide content, leading to unpredictable efficacy and dosing challenges.

• Poor Solubility & Bioavailability: High levels of plant waxes and chlorophyll can hinder solubility and absorption.

• Harsh Processing: Use of high heat or toxic solvents (e.g., acetone, hexane) can degrade actives and leave harmful residues.

• Bitter Overload: Uncontrolled bitterness can make formulation for palatable finished products extremely difficult.

SRBio’s Manufacturing Edge:

• Bio-Optimized Potency: Guaranteed andrographolide levels through precise chromatographic purification, not just raw concentration.

• Clean Label Extraction: Utilizes only GRAS solvents (ethanol/water) in a closed-loop system, ensuring a pure, solvent-free final product.

• Formulator-Friendly: Consistent physical characteristics (density, particle size) and optional excipient blending for taste-masking or enhanced flow.

Technical Partnership Program

1. Co-Development Services

   • Custom Standardization: We can tailor extracts to your exact specification, including specific ratios of andrographolide to other diterpene lactones.

   • Formulation Support: Our lab can assist with stability testing, taste-masking strategies, and compatibility studies with other botanicals or vitamins.

2. Market-Ready Solutions

   • Custom Blends:

     • ImmunoShield™: Andrographis Extract + Elderberry + Zinc + Vitamin C for comprehensive immune defense.

     • RespiraClear®: Andrographis Extract + N-Acetylcysteine (NAC) + Quercetin for targeted respiratory support.

   • Private Label Kits: Turnkey formulas for capsules (e.g., 300mg of 10% extract), tinctures, or effervescent tablets with custom branding.

Receive 1kg/5kg trial batches with COA + MSDS within 72 hours

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We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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