SRBio Co-Crystallized Curcumin: 48X Higher Bioavailability
BREAKTHROUGH TECHNOLOGY
1. Patented Co-Crystallization (US 11,358,742 B2)
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Mechanochemistry Process:
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No Solvents: Dry grinding with GRAS carriers (e.g., β-cyclodextrin, PVP-VA64)
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Energy-Efficient: 70% lower energy vs. spray drying (per kg output)
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Supramolecular Structure:
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Hydrogen-bonded curcumin-carrier lattice (confirmed via PXRD)
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Prevents recrystallization >36 months (ICH accelerated testing)
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2. Superior Bio-Performance
| Parameter | SRBio Co-Crystal | Standard 95% Curcumin |
|---|---|---|
| Relative Bioavailability | 48X (human) | 1X (baseline) |
| C<sub>max</sub> (ng/mL) | 420 ± 32 | 9.1 ± 1.5 |
| T<sub>1/2</sub> (h) | 8.7 | 1.2 |
| *Source: 12-week RCT, n=80 (J. Funct. Foods 2024)* |
QUALITY VALIDATION
Triple-Phase QC Protocol
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Raw Material:
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Curcuma longa rhizome HPLC ≥95% curcuminoids (USP <561>)
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Heavy metals: As <0.2 ppm, Cd <0.1 ppm (ICP-MS)
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In-Process:
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Crystallinity ≥98% (PXRD)
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Residual moisture ≤2.0% (Karl Fischer)
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Finished Product:
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Dissolution ≥95% in 30 min (USP <711>, pH 6.8)
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Microbial: Absence of E. coli, Salmonella (ISO 6579)
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Certifications:
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Regulatory: FDA GRAS Notice 1183, EFSA Novel Food 2023/1941, Japan JHNFA
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Purity: ISO 9001:2015, FSSC 22000, Halal (IFANCA), Kosher (OU)
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Eco: Carbon Neutral (Scope 1/2 verified), USDA BioPreferred 97%
TECHNICAL SPECIFICATIONS
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Bright orange powder | Visual |
| Particle Size | D<sub>50</sub>: 15μm (D<sub>90</sub>≤40μm) | ISO 13320 |
| Bulk Density | 0.45 g/cm³ | USP <616> |
| Tap Density | 0.62 g/cm³ | USP <616> |
| Solubility (25°C) | Water: ≥50 mg/mL | USP <1231> |
| ORAC Value | 1,200,000 μmol TE/g | Brunswick Labs SOP |
APPLICATION ENGINEERING
Nutraceuticals
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Tablets/Capsules:
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Dosage: 50mg = 2,400mg standard curcumin efficacy
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Excipient Compatibility: Starch, MCC, SiO<sub>2</sub>
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Gummies:
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Loading: Up to 7% w/w without sedimentation
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pH Stability: 3.0-5.0 (∆E<5 after 12 months)
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Beverages
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Clear Drinks: 0.1% w/v solubility (no cloudiness at pH 3.5-7.0)
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Emulsions: Oil-in-water stability ≥24 months (accelerated testing)
Topicals
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Skin Penetration: 3.2X flux vs. nano-emulsion (Franz cell, 0.5% dose)
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Formulation: Compatible with serums (≤1.0%), creams (≤3.0%)
GLOBAL COMPLIANCE DOCUMENTATION
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Full Dossiers:
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FDA DMF #035214
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EU Active Substance Master File (ASMF)
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Japan’s FFC Notification Data
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Stability Reports:
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40°C/75% RH: ≤0.5% degradation/year (HPLC)
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Photostability: ICH Q1B compliant
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Safety:
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AMES test negative (OECD 471)
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Acute oral toxicity LD<sub>50</sub> >5,000 mg/kg (OECD 423)
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CUSTOMIZATION & SCALE
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Concentration: 20%, 35%, 50% curcuminoids (±2%)
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Carrier Systems:
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β-Cyclodextrin (food), PVP-VA64 (pharma), HPMC (organic)
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Production Capacity:
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Standard: 10,000 kg/month
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Rush: 2,000 kg/week (premium surcharge 15%)
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Packaging:
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25kg foil bags (nitrogen-flushed)
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IBC totes (500kg) with RFID tracking
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PARTNER PROGRAM
1. Technical Collaboration
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Free formulation troubleshooting (72h response)
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Joint patent development (3 pending carrier tech)
2. Sampling & Trials
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R&D Kit: 50g sample + 15pg Technical Data File
3. Commercial Terms
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MOQ: 1kg (stock), 500kg (custom carriers)
VALIDATION CASE
*”By switching to SRBio’s co-crystals, we reduced tablet size by 60% and achieved 92% customer retention for joint health SKUs. Their CoA automation cut our QC time by 80%.”*
— Michael Reynolds, Supply Chain Director, USA
*Results: 18-month commercial production, 27 batches, 0 QC failures*
Video & Articles
Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
