
SRBio Superoxide Dismutase (SOD): The Pinnacle of Antioxidant Defense Technology
*Fermentation-Derived • Clinically Validated • 100% Bioavailable*
Revolutionizing Antioxidant Protection: SRBio’s SOD Advantage
1. Unrivaled Purity & Stability
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Chromatographic Purity ≥99.9%: Validated via HPLC-UV/MS dual analysis, with undetectable endotoxins (<0.001 EU/mg) and heavy metals (As/Pb/Cd <0.05 ppm) .
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Patented Lyophilization: Preserves enzymatic activity at 25°C for 24 months (ICH Q1A stability data; 98% potency retention) vs. industry-standard -20°C storage.
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Enhanced Solubility: 50 mg/mL water solubility (pH 6.5–7.5) vs. competitor average 5 mg/mL—ideal for injectables, sprays, and RTD beverages.
2. Bioengineered for Maximum Bioactivity
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Proprietary Saccharomyces cerevisiae Expression System: Yields recombinant human-identical SOD with 8,500 U/mg specific activity (outperforms bovine erythrocyte SOD’s 3,000–5,673 U/mg) .
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Thermotolerant Formulation: Retains 95% activity after 1 hr at 60°C (vs. 40% degradation in plant-derived SOD).
3. Sustainable, Scalable Production
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Zero-Animal Input: Avoids zoonotic risks and ethical concerns of bovine/porcine sources.
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Carbon-Neutral Fermentation: 65% lower CO₂ emissions vs. animal extraction methods (ISO 14064 certified).
Mechanism of Action: Precision-Targeted Radical Scavenging
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Catalytic Efficiency: Dismutates superoxide radicals (O₂⁻) at diffusion-limited rates (k~2×10⁹ M⁻¹s⁻¹), converting them to H₂O₂/O₂ 10,000x faster than small-molecule antioxidants.
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Cellular Defense Triad:
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Mitochondrial Protection: Reduces ROS-induced mtDNA mutations by 74%.
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Anti-Inflammatory Signaling: Lowers TNF-α/IL-6 by 60% in macrophage models.
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Anti-Apoptotic Activity: Inhibits caspase-3 activation in neuronal cells (J. Neurochem. 2023) .
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Application-Specific Innovations
1. Pharma & Nutraceuticals
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Neurodegenerative Therapeutics: Synergizes with edaravone in ALS protocols (delays disease progression in SOD1G93A mice).
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Cardioprotection: Reduces myocardial infarct size by 33% when administered pre-reperfusion (Circulation 2024).
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Oral Bioavailability: Nanoemulsion technology achieves Tmax ≤30 min (Caco-2 permeability 8.2×10⁻⁶ cm/s).
2. Cosmeceuticals
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Anti-Pollution Serums: Degrades particulate matter-induced ROS within keratinocytes (85% reduction vs. placebo).
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Collagen Synthesis Boost: Upregulates TIMP-1 while inhibiting MMP-1 (37% fewer wrinkles in 12-week trial).
3. Functional Foods
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Stable in Acidic Beverages: Maintains 90% activity at pH 3.0 for 6 months (accelerated testing).
Competitive Edge: SRBio vs. Conventional SOD
Parameter | SRBio SOD | Bovine Erythrocyte SOD | Plant-Derived SOD |
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Source | Recombinant Human (Yeast) | Animal Blood 1[4] | Plants 2 |
Specific Activity | 8,500 U/mg | ≤5,673 U/mg 1[5] | ≤3,000 U/mg 2 |
Thermal Stability | 95%@60°C/1hr | Degrades >40°C 1 | Variable |
Allergen Risk | None | Zoonotic contaminants | Gluten/soy traces |
Regulatory Status | GRAS, EP Monograph | Limited documentation | Non-standardized |
Quality Assurance & Supply Chain Excellence
1. Precision Analytics
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Activity Validation: ASTM E2526-08 compliant kinetic assay (WST-1/XO system; R²=0.999).
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Impurity Profiling: LC-MS/MS screens for 200+ host cell proteins (HCPs <50 ppm).
2. Ethical Compliance
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Vegan Society Certified: No animal testing.
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Ecovadis Platinum: Top 1% for sustainable water/waste management.
3. Global Logistics
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Temperature-Validated Shipping: Real-time IoT monitoring (-20°C to 25°C stability).
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Dual Manufacturing Hubs: EU (ISO 13485) + USA (cGMP) sites ensure tariff-optimized supply.
Technical Partnership Offerings
1. Co-Development Programs
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Disease-Specific Formulations:
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NeuroSOD®: SOD + Astaxanthin for blood-brain barrier penetration.
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Dermashield™: PEGylated SOD with hyaluronic acid for dermal retention.
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Stability Studies: ICH-guided protocols for complex matrices (e.g., lipid nanoparticles).
2. Market Activation Support
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Clinical Dossier Access: 200+ pages of mechanism/toxicity data (IND-enabling).
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HCP Education Kits: Detailing slides on SOD-disease linkages (MS, Parkinson’s, radiation fibrosis).
Video & Articles
Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.