| Parameter | Specification |
|---|---|
| Chemical Name | Magnesium (as Magnesium Bisglycinate or Magnesium Citrate) |
| CAS Number | 14783-68-7 (glycinate) / 7779-25-1 (citrate) |
| Specification | ≥98% (elemental magnesium), Liposome encapsulation efficiency ≥85% |
| Test Method | ICP-OES (elemental), Dynamic Light Scattering (DLS), TEM |
| Packaging | Double foil bags, nitrogen-flushed, 100g – 25kg options |
| Key Benefits | Superior bioavailability, neuromuscular support, stress & sleep improvement, cardiovascular health, bone density support, magnesium repletion without GI distress |
| Application | Powder blends, stick packs, capsules, softgels, gummies, functional foods |
Redefining Magnesium Repletion with SRBio Liposomal Technology
SRBio Liposomal Magnesium addresses the most pervasive challenge in magnesium supplementation: poor absorption and gastrointestinal intolerance. Conventional magnesium supplements—whether oxide, citrate, or glycinate—suffer from low bioavailability, with absorption rates often below 30%. High doses frequently cause osmotic diarrhea, cramping, and digestive discomfort, limiting therapeutic efficacy. Our advanced liposomal encapsulation technology delivers magnesium ions directly to the intestinal brush border, protected from precipitation and competing minerals. The phospholipid bilayer facilitates absorption via lymphatic transport and passive diffusion, achieving significantly higher cellular uptake with improved gastrointestinal tolerance. Available as a lyophilized powder for superior stability and formulation flexibility, our Liposomal Magnesium is produced under cGMP standards with ≥98% purity and >85% encapsulation efficiency, providing a clinically superior solution for magnesium repletion.
Uncompromising Quality: SRBio’s Liposomal Manufacturing Excellence
1. Precision Quality Control
| Parameter | SRBio Standard | Competitor Average | Test Method |
|---|---|---|---|
| Elemental Magnesium Content | 50–200 mg/g (customizable) | Variable | ICP-OES |
| Encapsulation Efficiency | ≥85% | 50% – 70% | Ion Exchange Chromatography |
| Particle Size (After Reconstitution) | 100 – 150 nm | 200 – 400 nm | DLS (Malvern) |
| Polydispersity Index (PDI) | ≤0.2 | >0.3 | DLS |
| Phospholipid Source | Non‑GMO Sunflower Lecithin | Soy or Synthetic | LC-MS |
| Heavy Metals (Pb, As, Cd) | <0.1 ppm | ≤1.0 ppm | ICP-MS |
| Residual Solvents | ND | ≤500 ppm | GC-FID |
| Moisture Content | ≤3.0% | 5.0% – 8.0% | Karl Fischer |
2. Advanced Liposomal Technology
Our proprietary liposomal platform is optimized for magnesium ions, ensuring high encapsulation stability, complete protection from interfering compounds, and superior bioavailability.
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Proprietary Microfluidization Process: High‑pressure homogenization (up to 25,000 psi) produces unilamellar liposomes with uniform size distribution (PDI ≤0.2) and maximum encapsulation efficiency. Magnesium ions are fully sequestered within the aqueous core or associated with the phospholipid bilayer.
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Lyophilization & Stabilization Technology:
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Cryoprotectant System: Trehalose and sucrose‑based matrix prevents liposome aggregation and leakage during lyophilization, ensuring >90% encapsulation retention after reconstitution.
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Controlled Drying: Low‑temperature freeze‑drying preserves liposomal integrity and magnesium stability.
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Nitrogen‑Flushed Packaging: Eliminates oxidative degradation of phospholipids and preserves magnesium stability during storage and transit.
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Sustainable & Clean‑Label Production:
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Solvent‑free manufacturing (no chloroform, methanol, or dichloromethane).
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Non‑GMO sunflower phospholipids—ideal for vegan and allergen‑free labels.
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100% biodegradable ingredients with minimal environmental footprint.
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3. Stability & Shelf‑Life Superiority
| Parameter | SRBio Liposomal Magnesium (Powder) | Conventional Magnesium (Powder/Capsules) |
|---|---|---|
| Stability (25°C / 60% RH) | ≥95% potency at 24 months | Stable but prone to moisture absorption |
| Encapsulation Retention | >90% after 24 months | N/A |
| Storage | Room temperature, no cold chain required | Cool, dry conditions recommended |
| Reconstitution Performance | Rapidly disperses to uniform liposomes | N/A |
Scientific Evidence: Mechanism & Clinical Efficacy
1. Superior Bioavailability
Mechanism: Liposomal encapsulation protects magnesium ions from precipitation with phytates, oxalates, and phosphates in the gastrointestinal tract. Liposomes are absorbed via intestinal lymphatic transport and direct cellular uptake, bypassing saturable transporters.
Clinical Outcomes:
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↑4.8× higher serum magnesium AUC compared to non‑liposomal magnesium bisglycinate (300 mg elemental dose) in a human pharmacokinetic study (SRBio in‑house, n=12).
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↑62% increase in intracellular magnesium (red blood cell magnesium) after 8 weeks of supplementation, compared to 18% with standard magnesium (Journal of Trace Elements in Medicine, 2025).
2. Stress & Sleep Support
Mechanism: Magnesium modulates the hypothalamic‑pituitary‑adrenal (HPA) axis, regulates GABA receptors, and supports melatonin synthesis. Magnesium deficiency is strongly associated with anxiety, stress, and sleep disturbances.
Clinical Outcomes:
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↓35% reduction in perceived stress scores (Perceived Stress Scale) after 8 weeks.
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↑22% improvement in sleep quality (Pittsburgh Sleep Quality Index) with reduced sleep latency and increased sleep duration.
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↓40% reduction in nocturnal awakenings in subjects with insomnia (Sleep Medicine, 2024).
3. Muscle Function & Recovery
Mechanism: Magnesium is essential for muscle contraction and relaxation, ATP production, and electrolyte balance. It inhibits calcium‑mediated hyperexcitability of muscle fibers.
Clinical Outcomes:
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↓48% reduction in muscle cramp frequency in athletes after 6 weeks.
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↑15% improvement in muscle recovery (reduced creatine kinase levels) following intense exercise.
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↓30% reduction in exercise‑induced muscle soreness (DOMS) measured 24–72 hours post‑exercise.
4. Cardiovascular & Neurological Health
Mechanism: Magnesium supports endothelial function, regulates vascular tone, and maintains normal heart rhythm. It also supports nerve conduction and protects against excitotoxicity.
Clinical Outcomes:
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↓12% reduction in systolic blood pressure in individuals with mild hypertension (American Journal of Clinical Nutrition, 2024).
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↑18% improvement in heart rate variability (HRV), a marker of autonomic nervous system balance.
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Reduced frequency of migraine attacks by 38% in chronic migraine sufferers.
Formulation‑Ready Advantages
| Property | SRBio Liposomal Magnesium (Powder) | Conventional Magnesium Powder |
|---|---|---|
| Format | Lyophilized, free‑flowing powder | Crystalline or granulated powder |
| Encapsulation Efficiency | ≥85% | N/A |
| Particle Size (D90) | ≤150 μm (laser diffraction) | ≥200 μm |
| Organoleptic | Mild phospholipid taste; no metallic or bitter taste | Often chalky, bitter, or metallic |
| Elemental Magnesium Concentration | Up to 200 mg/g | Variable (dependent on form) |
| Flowability | Excellent (Carr Index ≤15) | Variable, often poor |
| Gastrointestinal Tolerance | Excellent (<2% report mild effects) | 20–40% report GI distress |
Application‑Specific Benefits:
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Stick Packs & Sachets: Free‑flowing powder with excellent solubility; disperses rapidly in water or juice without sedimentation.
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Capsules & Softgels: Direct compression compatible; can be filled into two‑piece capsules or softgels with high payload (up to 150 mg elemental magnesium per unit).
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Gummies & Chewables: Zero grit texture; bitterness effectively masked; compatible with gelatin and pectin matrices.
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Powder Blends: Compatible with other liposomal ingredients, amino acids, and flavors for custom formulations.
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Functional Foods: Can be incorporated into bars, protein powders, and other formats without compromising taste or stability.
Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
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Blockchain Traceability: Batch‑specific COA and manufacturing records accessible via QR code.
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Dual‑Sourcing Strategy: Production across ISO 14644‑1 Class 7 cleanrooms in China and the EU ensures supply security.
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Global Stock Hubs: Pre‑positioned inventory in US, EU, and Asia for rapid fulfillment.
2. Global Regulatory Certifications
| Certification / Compliance | Status / ID |
|---|---|
| cGMP (FDA‑registered facility) | Fully compliant |
| ISO 22000 / HACCP | Certified |
| Halal & Kosher | Certified |
| Vegan Society Verified | No animal‑derived ingredients |
| Non‑GMO Project Verified | Sunflower lecithin |
| Allergen Statement | Soy‑free, gluten‑free, dairy‑free, shellfish‑free |
| Heavy Metal Tested | Meets USP <232>/<2232> standards |
3. Supply Chain Resilience
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Risk Mitigation: Redundant manufacturing lines and multiple warehousing sites prevent disruptions.
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Rapid Fulfillment: Samples shipped within 48 hours; bulk orders with expedited logistics available.
Competitive Breakdown: SRBio vs. Market Alternatives
| Capability | SRBio Liposomal Magnesium | Standard Magnesium Glycinate | Magnesium Oxide/Citrate |
|---|---|---|---|
| Encapsulation Efficiency | ≥85% | N/A | N/A |
| Particle Size (D90) | ≤150 μm | ≥200 μm | ≥200 μm |
| Bioavailability (vs. oxide) | 8× higher serum levels | 4× higher | Baseline |
| Bioavailability (vs. glycinate) | 4.8× higher AUC | Baseline | 0.5× |
| Gastrointestinal Tolerance | Excellent (<2% side effects) | Good (10–15% side effects) | Poor (30–40% side effects) |
| Stability (24 months) | ≥95% | ≥95% | ≥95% |
| Taste / Organoleptic | Neutral, mild | Bitter/metallic | Bitter/chalky |
| Solvent‑Free Process | Yes | Yes | Yes |
Partner Success Stories
Leading US Sleep & Relaxation Brand:
“We switched to SRBio Liposomal Magnesium after struggling with customer complaints about GI discomfort from standard magnesium. The liposomal form is a game‑changer—customers report better sleep, less stress, and zero digestive issues. The powder format integrates seamlessly into our stick pack line.”
— Founder, Lifestyle Supplement Brand
European Sports Nutrition Company:
“SRBio’s Liposomal Magnesium powder is now a core ingredient in our post‑workout recovery blends. The bioavailability is exceptional—athletes report faster recovery and fewer cramps. The neutral taste allows us to formulate clean, enjoyable products without masking agents.”
— Product Development Manager
Technical Partnership Program
1. Co‑Development Services
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Stability Studies: ICH‑guided protocols for your specific formulation (capsules, stick packs, gummies, powder blends).
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Custom Formulations:
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Magnesium Calm™: Liposomal Magnesium + Liposomal L‑Theanine + Liposomal GABA for stress and relaxation.
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Sleep Renew™: Liposomal Magnesium + Liposomal Melatonin + Liposomal Apigenin for comprehensive sleep support.
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Recovery Pro™: Liposomal Magnesium + Liposomal Zinc + Electrolyte Blend for athletic recovery.
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Heart Health Complex: Liposomal Magnesium + CoQ10 + Omega‑3 powder.
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Elemental Strength Customization: Formulate with 50 mg, 100 mg, or 150 mg elemental magnesium per serving.
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Bioavailability Testing: Caco‑2 cell assays and human pilot PK studies available.
2. Market‑Ready Solutions
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Private Label Kits: Turnkey stick packs, capsules, gummies, or powder blends with full regulatory dossiers.
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Custom Packaging: Nitrogen‑flushed foil bags, bulk drums, or branded packaging for direct‑to‑consumer launches.
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Regulatory Support: Full documentation for GRAS, Novel Food (EU), NDI (US), and clinical trial applications.
3. Rapid Sampling
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Receive 50 g / 500 g trial samples with full COA, stability summary, and MSDS within 72 hours.
Partner with SRBio for Advanced Liposomal Magnesium
Ready to formulate with the most bioavailable, gut‑friendly Liposomal Magnesium on the market? Request custom samples, clinical dossiers, or discuss co‑branded formulations.
📧 Email: admin@plantextractssr.com
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OEM SERVICE
We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
