| Parameter | Specification |
|---|---|
| Chemical Name | Calcium L-Threonate |
| CAS Number | 70753-61-6 |
| Molecular Formula | C₈H₁₄CaO₁₀ |
| Molecular Weight | 310.27 g/mol |
| Specification | Calcium Content: 12.5% – 13.5%; L-Threonic Acid: ≥86% (HPLC); Heavy Metals: <10 ppm |
| Test Method | EDTA Titration (Calcium), HPLC (L-Threonic Acid), ICP-MS (Heavy Metals) |
| Packaging | 25 kg/drum with double food-grade polyethylene liners; customizable smaller sizes available |
| Key Properties | Fully water-soluble, neutral taste, stable across pH 3–9, non-hygroscopic |
| Application | Dietary supplements, functional beverages, chewable tablets, senior nutrition, cognitive health formulations |
Achieve Superior Calcium Solubility and Bioavailability with SRBio Calcium L-Threonate
SRBio Calcium L-Threonate is a high-purity, organically bound calcium salt derived from L-threonic acid, a metabolite of vitamin C. Unlike conventional calcium sources such as carbonate or citrate, this unique molecular structure offers exceptional solubility and absorption characteristics, making it an ideal choice for premium nutritional formulations where bioavailability, sensory neutrality, and formulation stability are critical.
Uncompromising Quality: SRBio’s Manufacturing Excellence
1. Precision Purity Control
| Parameter | SRBio Standard | Industry Typical | Test Method |
|---|---|---|---|
| Calcium Content | 12.5% – 13.5% | 10.0% – 12.0% | EDTA Complexometric Titration |
| L-Threonic Acid Purity | ≥86.0% | 80.0% – 85.0% | HPLC-DAD |
| Heavy Metals (Total) | <10 ppm | ≤20 ppm | ICP-MS |
| Lead (Pb) | <0.5 ppm | ≤1.0 ppm | ICP-MS |
| Arsenic (As) | <0.5 ppm | ≤1.0 ppm | ICP-MS |
| Cadmium (Cd) | <0.1 ppm | ≤0.5 ppm | ICP-MS |
| Mercury (Hg) | <0.05 ppm | ≤0.1 ppm | ICP-MS |
| Loss on Drying | ≤2.0% | ≤5.0% | Karl Fischer |
| pH (1% aqueous solution) | 6.5 – 8.0 | 5.0 – 7.0 | pH Meter |
2. Advanced Synthesis & Purification Technology
High-Purity Aqueous Synthesis
SRBio employs a controlled, water-based synthesis process that ensures a consistent 1:2 molar ratio of calcium to L-threonate. The reaction is carried out under strictly controlled pH and temperature conditions (<60°C) to prevent degradation of the threonic acid moiety and ensure complete conversion.
Multi-Stage Purification Process
-
Microfiltration: Removes particulate matter and potential microbial contaminants.
-
Nanofiltration Desalination: Reduces residual chloride and sodium ions to ≤0.1%, ensuring a clean, neutral taste profile.
-
Controlled Crystallization: Optimized solvent system (ethanol/water) yields uniform crystalline particles with consistent polymorphic form.
-
Low-Temperature Vacuum Drying: Gentle drying at ≤50°C preserves the integrity of the calcium-threonate complex and prevents thermal degradation.
Exceptional Solubility & Stability
-
Complete Solubility: ≥99.9% solubility in water at 25°C, forming a clear, colorless solution with no sedimentation.
-
Wide pH Stability: Remains fully soluble and chemically stable across pH 3–9, making it suitable for acidic beverages (e.g., fruit juices) and neutral systems (e.g., dairy alternatives).
-
Long-Term Stability: Accelerated stability studies confirm calcium content and physical appearance remain stable for 24 months under ambient conditions (25°C/60% RH), with no caking, discoloration, or loss of solubility.
Sensory Excellence
-
Neutral Taste: No metallic aftertaste, chalkiness, or bitterness—unlike calcium carbonate or citrate.
-
Low Hygroscopicity: Maintains free-flowing powder characteristics even under moderate humidity, ensuring ease of handling during manufacturing.
Scientific Basis & Functional Advantages
1. Unique Organic Calcium Matrix
As the calcium salt of L-threonic acid, this compound provides calcium in a highly soluble form that does not require gastric acid for dissolution. This makes it particularly suitable for applications targeting individuals with reduced digestive capacity, such as older adults, or for use in liquid formulations where rapid dissolution is essential.
2. High Solubility & Absorption Potential
The complete solubility of Calcium L-Threonate in water allows it to be readily available for absorption throughout the gastrointestinal tract. Unlike poorly soluble calcium salts that require gastric acid for ionization, Calcium L-Threonate remains in solution, potentially reducing the risk of gastrointestinal discomfort often associated with other calcium forms.
Comparative Solubility (25°C, g/100mL water):
| Calcium Form | Solubility |
|---|---|
| Calcium L-Threonate | >100 (freely soluble) |
| Calcium Citrate | 0.1 (sparingly soluble) |
| Calcium Carbonate | 0.001 (insoluble) |
3. Dual-Action Functional Potential
In addition to serving as a highly bioavailable calcium source, the L-threonate component has been independently studied for its role in supporting cognitive health and magnesium transport. This dual functionality offers formulation opportunities beyond traditional bone health products, positioning Calcium L-Threonate as a versatile ingredient for comprehensive wellness formulations.
4. High Gastrointestinal Tolerance
Because Calcium L-Threonate does not require gastric acid for dissolution and does not generate gas as a byproduct, it is generally well tolerated. It does not cause the bloating, constipation, or belching sometimes associated with inorganic calcium sources.
Technical Specifications & Formulation-Ready Advantages
| Parameter | SRBio Calcium L-Threonate Standard | Test Method |
|---|---|---|
| Appearance | White to off-white, free-flowing crystalline powder | Visual Inspection |
| Calcium Content (on dry basis) | 12.5% – 13.5% | EDTA Complexometric Titration |
| L-Threonic Acid Content | ≥86.0% | HPLC-DAD |
| pH (1% aqueous solution) | 6.5 – 8.0 | pH Meter |
| Loss on Drying | ≤2.0% | Karl Fischer |
| Solubility (25°C) | ≥99.9% (clear solution) | Visual / Filtration & Gravimetry |
| Bulk Density (untapped) | 0.55 – 0.75 g/mL | USP <616> |
| Tapped Density | 0.70 – 0.90 g/mL | USP <616> |
| Particle Size (D90) | ≤150 μm | Laser Diffraction |
| Heavy Metals (Total) | <10 ppm | ICP-MS |
| Lead (Pb) | <0.5 ppm | ICP-MS |
| Arsenic (As) | <0.5 ppm | ICP-MS |
| Cadmium (Cd) | <0.1 ppm | ICP-MS |
| Mercury (Hg) | <0.05 ppm | ICP-MS |
| Total Aerobic Microbial Count | ≤1,000 CFU/g | USP <61> |
| Total Yeast & Mold Count | ≤100 CFU/g | USP <61> |
| E. coli / Salmonella | Negative /25g | USP <62> |
Formulation-Ready Benefits by Application:
| Application | Key Advantage |
|---|---|
| Clear RTD Beverages | Complete solubility with no sedimentation; stable in acidic (pH 3–5) and neutral pH systems; no off-taste. |
| Powdered Drink Mixes | Rapid dispersion; compatible with flavors and sweeteners; non-hygroscopic for extended shelf life. |
| Chewable & Effervescent Tablets | Neutral taste allows for pleasant flavor profiles; good compressibility without the need for excessive excipients. |
| Dairy & Plant-Based Beverages | Integrates smoothly without causing protein flocculation or sedimentation; heat-stable for UHT processing. |
| Capsules & Tablets | Excellent flowability and compressibility enable high-dose, small-diameter tablets with reduced excipient use. |
| Senior & Pediatric Nutrition | Gentle on the stomach; requires no gastric acid for absorption; neutral taste improves compliance. |
Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
Full Traceability: Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing calcium content, L-threonate purity, heavy metals, microbiology, and physical properties. Complete production records, including raw material sourcing and in-process quality checks, are available for qualified client audits.
Rapid Sampling: 50 g or 500 g R&D samples shipped within 72 hours with full COA + MSDS.
2. Global Regulatory Certifications
| Certification / Compliance | Status |
|---|---|
| ISO 22000 | Certified (all production sites) |
| Kosher & Halal | Certified |
| Non-GMO | Verified; produced from non-GMO raw materials |
| Allergen-Free Statement | Gluten-free, soy-free, dairy-free, egg-free, peanut-free (ELISA tested) |
| Vegan | No animal-derived ingredients used |
| China GB 14880 | Compliant for nutritional fortification |
| US Dietary Supplement | NDI-ready dossiers available |
| EU Novel Food | Compliance documentation available |
3. Supply Chain Resilience
-
Redundant Manufacturing: Multiple production lines and buffer capacity ensure uninterrupted supply.
-
Global Stock Hubs: Pre-positioned inventory in North America, Europe, and Asia for rapid fulfillment.
-
Capacity: 10 MT/month standard, expandable to meet growing demand.
Competitive Breakdown: SRBio vs. Market Alternatives
| Capability | SRBio Calcium L-Threonate | Conventional Calcium L-Threonate / Other Calcium Salts |
|---|---|---|
| Purity (L-Threonic Acid) | ≥86.0% (HPLC) | 80.0% – 85.0%, often ≤82% |
| Batch-to-Batch Consistency | ±0.3% calcium variance | ±1.0% or higher |
| Solubility | ≥99.9% (clear solution) | Variable, often cloudy or sediment |
| Heavy Metals | <10 ppm total | ≤20 ppm or higher |
| Residual Chloride | ≤0.1% | ≤1.0% (can affect taste) |
| pH Consistency | 6.5–8.0 | 5.0–7.0, often acidic |
| Microbial Control | USP <61> compliant, endotoxin monitored | Variable, risk of contamination |
| Documentation | Full COA with all parameters, traceability | Limited or incomplete |
| Lead Time | 2–3 weeks (bulk orders) | 4–8 weeks, variable |
Technical Partnership Program
1. Co-Development Services
Formulation Support
Our applications lab can assist with stability testing in your specific matrix, whether acidic beverages, protein bars, or high-moisture systems. We offer ICH-guided stability protocols tailored to your finished product format.
Analytical Method Transfer
We provide validated HPLC and titration methods for in-process and finished product quality control, enabling seamless integration into your quality management system.
Custom Solutions
-
Particle Size Optimization: Custom milling to meet specific particle size distribution requirements for direct compression or suspension applications.
-
Custom Blends: Pre-validated combinations with complementary ingredients (see below).
-
Packaging Options: Nitrogen-flushed foil bags, moisture-barrier drums, or branded private label packaging.
2. Market-Ready Solutions
Custom Premixes
| Blend Name | Composition | Target Application |
|---|---|---|
| Bone & Cognitive Support | Calcium L-Threonate + Magnesium L-Threonate + Vitamin D3 | Bone health, cognitive wellness, senior nutrition |
| Calcium Plus System | Calcium L-Threonate + Vitamin K2 (MK-7) + Zinc | Bone mineralization, cardiovascular support |
| Sleep & Calm | Calcium L-Threonate + Magnesium Bisglycinate + L-Theanine | Relaxation, sleep support |
| Women’s Wellness | Calcium L-Threonate + Vitamin D3 + Boron | Bone health for perimenopausal and postmenopausal women |
Private Label Ready
Turnkey formulations available for:
-
Capsules (500 mg, 750 mg, 1000 mg)
-
Chewable tablets (fruit flavors available)
-
Effervescent tablets (lemon, orange, berry)
-
Instant powder sticks (single-serving sachets)
Partner with SRBio for High-Purity, Formulation-Ready Calcium L-Threonate
Ready to formulate with the world’s most soluble, neutral-tasting calcium source? Request custom samples, technical dossiers, or discuss co-development opportunities for your next-generation bone health, cognitive wellness, or functional beverage products.
→ Email: admin@plantextractssr.com
Shipping & Packing Information
OEM SERVICE
We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
