| Parameter | Specification |
|---|---|
| Chemical Name | Calcium beta-hydroxy-beta-methylbutyrate monohydrate (HMB-Ca) |
| CAS Number | 135236-72-5 |
| Molecular Formula | C₁₀H₁₈CaO₆ |
| Molecular Weight | 274.32 |
| Specification (Purity) | ≥98.5% (HPLC) |
| Test Method | HPLC-UV, ICP-MS, GC (USP/EP compliant) |
| Packaging | 25kg/drum, double food-grade poly bags inside. Nitrogen-flushed foil packaging available. |
| Key Benefits | Inhibits muscle protein breakdown, activates mTOR for muscle synthesis, accelerates recovery, supports lean mass gain |
| Application | Sports nutrition, clinical nutrition (cancer/ICU), healthy aging, functional foods & beverages |
Unlock Muscle Preservation & Performance with SRBio HMB-Ca
SRBio HMB-Ca is a high-purity, calcium salt of beta-hydroxy-beta-methylbutyrate (HMB), a clinically validated leucine metabolite. As a potent anti-catabolic agent, it uniquely inhibits muscle protein breakdown while simultaneously supporting protein synthesis via the mTOR pathway. Produced under strict cGMP and ISO 22000 standards, our HMB-Ca offers superior purity (≥98.5%), controlled particle size, and exceptional stability for demanding formulations—from RTD beverages to high-protein bars.
Uncompromising Quality: SRBio’s Manufacturing Excellence
1. Precision Purity Control
| Parameter | SRBio Standard | Industry Average | Test Method |
|---|---|---|---|
| Purity (HPLC) | ≥98.5% | 95% – 97% | HPLC-UV (USP) |
| Heavy Metals (Pb, As, Cd) | <1 ppm | <5 ppm | ICP-MS |
| Residual Solvents (Class 1-3) | ND | ≤50 ppm | GC-FID |
| Total Aerobic Microbial Count | <10 CFU/g | <100 CFU/g | USP <61> |
| Endotoxin (for clinical grade) | <0.1 EU/mg | ≤1.0 EU/mg | Kinetic LAL |
| Loss on Drying | ≤0.5% | ≤1.0% | USP <731> |
2. Advanced Manufacturing & Process Control
Vertical Integration:
SRBio synthesizes its own starting material, keto-isocaproate, ensuring batch-to-batch consistency and complete supply chain transparency—unlike suppliers reliant on variable third-party intermediates.
Dedicated Production Line:
Our FDA-inspected, cGMP-certified facility operates a dedicated line for HMB-Ca to prevent cross-contamination with allergens or other actives.
Controlled Crystallization:
Proprietary crystallization parameters yield a consistent, non-hygroscopic crystalline form with:
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Bulk Density: 0.50 – 0.65 g/cm³ (optimized for blending)
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Particle Size (D90): ≤80 μm for standard powder; custom granulations available (150–500 μm) for direct compression or ready-to-mix applications.
Custom Granulation & Coating:
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Heat-Stable Microencapsulation: Maintains integrity up to 180°C, ideal for protein bars and baked functional foods.
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Instant-Dissolving Granules: Prevent clumping in RTD powders and effervescent tablets; complete dissolution <30 seconds in cold water.
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Enteric Coating Options: Available for targeted delivery in clinical formulas.
3. Stability & Shelf-Life Superiority
| Storage Condition | Potency Retention (24 months) |
|---|---|
| 25°C / 60% RH (ICH Q1A) | ≥98.0% |
| 40°C / 75% RH (accelerated) | ≥97.5% after 6 months |
pH Stability:
Maintains integrity across pH 3.0–8.0, ensuring compatibility with acidic beverage matrices (e.g., sports drinks, RTD protein shakes) and neutral clinical nutrition formulas.
Protection from Moisture:
Standard packaging includes double food-grade poly bags with desiccant canisters; nitrogen-flushed foil packaging available for high-humidity regions.
Scientific Evidence: Mechanism & Clinical Efficacy
1. Inhibition of Muscle Protein Breakdown (Anti-Catabolic)
Mechanism of Action:
HMB acts as a leucine metabolite that inhibits the ubiquitin-proteasome proteolytic pathway, reducing muscle protein breakdown by up to 53% during catabolic states.
Clinical Evidence:
Nissen et al. (Journal of Applied Physiology, 1996) demonstrated that HMB supplementation (3g/day) significantly decreased markers of muscle damage (creatine kinase and lactate dehydrogenase) and reduced urinary excretion of 3-methylhistidine, a marker of protein degradation.
2. Activation of mTOR Pathway (Anabolic)
Mechanism:
HMB directly activates the mechanistic target of rapamycin (mTOR) signaling pathway, enhancing muscle protein synthesis independently of leucine.
Clinical Outcomes:
Wilson et al. (European Journal of Applied Physiology, 2014) reported that HMB supplementation resulted in 20% faster recovery of muscle function following resistance exercise, with enhanced activation of p70S6K, a key downstream marker of mTOR signaling.
3. Lean Mass Gains & Strength Improvement
Clinical Outcomes:
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Portal et al. (Journal of Inherited Metabolic Disease, 2011): In a randomized, double-blind, placebo-controlled trial, resistance-trained individuals receiving 3g/day HMB for 12 weeks experienced 2x greater lean mass increase compared to placebo.
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Vukovich et al. (Journal of Strength and Conditioning Research, 2001): Elderly adults (average age 70) taking HMB with resistance training showed significantly greater gains in lower body strength (by 18.5%) and lean body mass compared to training alone.
4. Clinical Nutrition Applications
Key Finding:
In catabolic patients (cancer cachexia, ICU, elderly), HMB combined with arginine and glutamine (the “HMB/Arg/Gln” formulation) has been shown to reduce hospital length of stay and improve wound healing outcomes (Deutz et al., Clinical Nutrition, 2016).
Formulation-Ready Advantages
| Property | SRBio HMB-Ca | Competitor Average |
|---|---|---|
| Solubility (H₂O, 25°C) | >250 mg/mL | 150–200 mg/mL |
| Bulk Density (powder) | 0.55 g/cm³ | 0.70 g/cm³ |
| Particle Size (D90) | ≤80 μm (customizable) | ≥150 μm |
| Hygroscopicity (75% RH, 25°C) | <1.0% weight gain in 24h | 2–5% weight gain (clumping) |
| Flowability | Excellent (Carr Index ≤18) | Variable, often poor |
| Taste Profile | Neutral, minimal aftertaste | Slightly bitter or soapy |
Application-Specific Benefits:
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RTD Beverages & Sports Drinks: Instant-dissolving granules prevent sedimentation; stable in acidic pH (3.0–4.5) for >12 months.
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Protein Bars & Functional Foods: Heat-stable microencapsulated form withstands baking temperatures up to 180°C without degradation.
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Effervescent Tablets: Low moisture absorption ensures tablet stability and prevents premature effervescence.
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Clinical Nutrition Powders: Ultra-pure grade (endotoxin <0.1 EU/mg) suitable for enteral and oral nutritional supplements.
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Capsules & Tablets: Direct compression compatible; ejection force ≤6 kN for high-speed rotary presses.
Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
Full Traceability:
Batch-specific Certificate of Analysis (CoA) includes raw material origin, in-process testing results, and final release data—available via secure portal.
Quality Management:
All production sites are ISO 22000 and cGMP certified, with regular FDA and customer audits.
Global Stock Hubs:
Pre-positioned inventory in North America, Europe, and Asia ensures rapid fulfillment with typical lead times ≤15 days.
2. Global Regulatory Certifications
| Certification / Compliance | Status |
|---|---|
| cGMP (US FDA) | Facility registered |
| ISO 22000 | Certified |
| NSF International | Certified (sports nutrition grade available) |
| GRAS (Self-Affirmed) | Full dossier available |
| TGA (Australia) | Compliance documentation ready |
| Halal & Kosher | Certified |
| Allergen Statement | Gluten-free, dairy-free, soy-free (ELISA tested) |
| Non-GMO | Verified |
3. Supply Chain Security
Risk Mitigation:
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Dual sourcing of key raw materials
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Redundant production lines across multiple facilities
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12-month rolling inventory buffer for critical SKUs
Rapid Sampling:
Receive 50g / 500g trial batches with full CoA + MSDS within 72 hours.
Competitive Breakdown: SRBio vs. Market Alternatives
Key Deficiencies in Low-Grade HMB-Ca:
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Variable Purity: 95–97% purity leads to inconsistent dosing and potential off-label impurities.
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Hygroscopicity: Poor moisture control results in clumping, caking, and reduced shelf life.
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Inconsistent Particle Size: Wide particle distribution causes segregation in blends and poor tablet compression.
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Solvent Residues: Trace solvents from inferior synthesis routes may require additional disclosure in clean-label products.
SRBio’s Quality Edge:
| Capability | SRBio HMB-Ca | Standard Industry Grade |
|---|---|---|
| Purity | ≥98.5% | 95–97% |
| Particle Size Control | ≤80 μm (powder) or custom granules | Variable, often >150 μm |
| Endotoxin Level | <0.1 EU/mg (clinical grade) | ≤1.0 EU/mg |
| Moisture Absorption (24h at 75% RH) | <1.0% | 2–5% (clumping risk) |
| Stability (40°C/75% RH, 6 months) | ≥97.5% potency | Often <95% |
| Manufacturing | Vertically integrated, dedicated line | Reliant on intermediates |
Partner Success Stories
Leading US Sports Nutrition Brand:
“SRBio’s HMB-Ca allowed us to launch a ‘clean label’ muscle recovery powder with guaranteed solubility and zero clumping. The technical team provided excellent support in optimizing our RTD formulation for pH stability.”
— Director of R&D
European Clinical Nutrition Company:
“We switched to SRBio for their ultra-pure HMB-Ca with endotoxin control. The batch-to-batch consistency and full traceability documentation met the rigorous requirements of our hospital nutrition products.”
— Quality Assurance Manager
Technical Partnership Program
1. Co-Development Services
Stability Studies:
ICH-guided protocols for your specific formulation matrix (e.g., HMB-Ca + whey protein in RTD, HMB-Ca in high-moisture bars).
Custom Particle Engineering:
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Granulation (150–500 μm) for direct compression or sachets
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Microencapsulation for heat stability up to 180°C
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Instant-dissolving granules for beverages
Custom Blends:
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MusclePreserve™: HMB-Ca + Vitamin D3 + Magnesium for healthy aging
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RecoveryMax™: HMB-Ca + Creatine Monohydrate + Taurine for post-workout
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Clinical Support Formula: HMB-Ca + Arginine + Glutamine (HMB/Arg/Gln)
2. Market-Ready Solutions
Private Label Kits:
Turnkey formulas for capsules (500 mg), sachets, effervescent tablets, or RTD powders.
Custom Packaging:
Nitrogen-flushed foil bags, drums with desiccants, or branded packaging for direct-to-consumer launches.
Regulatory Support:
Full dossiers for GRAS, TGA, NSF, and other global registrations to accelerate your market entry.
Partner with SRBio for Premium, Science-Backed HMB-Ca
Ready to formulate with the world’s most reliable HMB-Ca? Request custom samples, stability data, or discuss co-branded formulations.
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