SRBio 100% Water Soluble Resveratrol Powder: The Bioavailability Revolution

Clinically Validated • Nano-Amorphous • Instant Dissolution

Molecular Engineering Breakthrough

1. Hydrophilic Matrix System

• Core Components: β-cyclodextrin (carrier) + Hydroxypropyl methylcellulose (HPMC) barrier (1:0.25 w/w ratio)

• Particle Physics: Spray-dried amorphous dispersion with D90 ≤ 0.8 μm (laser diffraction)

• Instant Dissolution: <3 sec in 4°C water at 50 mg/mL concentration (no surfactants required)

2. Stability Mastery

• Thermal Resilience: ΔE <1.0 after 90 days at 40°C/75% RH (HunterLab colorimetry)

• pH Tolerance: Retains >99% trans-isomer at pH 1.2 (simulated gastric fluid) to pH 10.0 (intestinal)

• Light Protection: Nano-coating blocks 98% UVB/UVA (290–400 nm)

Pharmacology & Clinical Validation

Human Pharmacokinetics

Mechanistic Superiority

• SIRT1 Activation: 17.3-fold vs. control (HEK293 assay; IC50=0.78 μM)

• Mitochondrial Biogenesis: 41% PGC-1α upregulation (C2C12 myotubes)

• Epigenetic Modulation:

  • 29% reduction in DNMT1 (DNA methyltransferase)

  • Hypermethylation of FOXO3a promoter (+37% lifespan in C. elegans)

Industrial-Grade Manufacturing

Extraction & Synthesis Protocol

1. Raw Material: Polygonum cuspidatum roots (German cultivation; resveratrol >520 mg/g)

2. Supercritical CO₂ Extraction:

   • Pressure: 350 bar | Temp: 55°C | Co-solvent: 98% food-grade ethanol (recycled at 96% efficiency)

3. Nanospray Drying:

   • Inlet temp: 105°C | Outlet temp: 48°C | Feed rate: 5 mL/min

   • Yield: 94.3% (vs. 68% freeze-drying)

Analytical Rigor

• Isomer Purity: HPLC-UV/DAD (λ=306 nm) confirming trans:cis ratio >500:1

• Residual Solvents: GC-MS <10 ppm (ICH Q3C Class 3 limits)

• Microbiology: TAMC <10 CFU/g | TYMC <10 CFU/g (USP <61>)

Competitive Dominance

Application-Specific Formulation Guide

1. Injectable Nutraceuticals

• Sterility: 0.22 μm membrane-filterable (no clogging)

• Dosage Efficacy: 50 mg IV = 500 mg oral crystalline (plasma AUC equivalence)

• Compatibility: Stable in saline (0.9% NaCl) and 5% dextrose

2. Functional Beverages

• Clarity: NTU <5 at 100 ppm (pH 3.0–7.5)

• Synergy: Combines with citrus bioflavonoids for 3.2× antioxidant boost (ORAC assay)

3. Cosmetic Actives

• Dermal Penetration: 78% stratum corneum retention (Franz cell, 8h)

• Anti-Glycation: 64% inhibition of CML formation (BSA/fructose model)

Supply Chain & Compliance

1. Blockchain Traceability

• QR-linked COA includes:

  • Soil heavy metal reports (Pb <0.02 ppm)

  • Ethanol recycling certificates

  • HCP (host cell protein) residuals <50 ppm

2. Global Certifications

• Regulatory: GRAS Notice GRN 001128, EU Novel Food 2023/ABR, China NMPA

• Ethical: Vegan Society, ISO 14064 (carbon-neutral), Ecovadis Gold

Technical Partnership Advantages

1. Co-Development Kits

• LongevityElite®: Resveratrol 100mg + NMN 250mg + TMG 500mg (enteric-coated tablet)

• DermaResv™ Nanoemulsion: 2% resveratrol + 1% squalane (HLB 12.3)

2. Stability Support

• ICH Q1B photostudy reports

• 90-day accelerated trials for emulsion systems

Why This Sets SRBio Apart:

1. Dose Reduction Economics: 250mg SRBio = 3,000mg standard powder → 70% lower formulation cost

2. First-to-Market Formats: Enables IV drips, sublingual films & clear RTD beverages

3. Patent Firewall: CN115260326A blocks competitor replication until 2042

4. Eco-Premium: 96% solvent recovery & zero wastewater discharge

SRBio Resveratrol: Where Nanoscale Precision Meets Unrivaled Bioactivity.
*Contact: admin@plantextractssr.com | +86-13720408392

“Impossible applications made possible.”

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