Product Parameters & Specifications

Redefining Flavonoid Bioavailability with SRBio Liposomal Luteolin

SRBio Liposomal Luteolin represents a breakthrough in flavonoid delivery. Luteolin is a naturally occurring flavonoid widely found in fruits, vegetables, and herbs, recognized for its powerful antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. However, conventional luteolin suffers from extremely poor water solubility and notoriously low oral bioavailability, which severely limits its therapeutic potential.

Our advanced liposomal encapsulation technology solves this fundamental challenge. By encapsulating luteolin within protective phospholipid bilayers, SRBio Liposomal Luteolin shields the active compound from degradation in the digestive tract and facilitates direct cellular delivery via phospholipid bilayer fusion. Research has demonstrated that liposome encapsulation of luteolin improves solubility and bioavailability while achieving superior therapeutic outcomes compared to free luteolin. Produced under cGMP standards with ≥98% purity and ≥85% encapsulation efficiency, our Liposomal Luteolin delivers superior absorption and clinical efficacy for the anti-aging, neurocognitive health, metabolic support, and inflammatory response markets.

Uncompromising Quality: SRBio’s Liposomal Manufacturing Excellence

1. Precision Quality Control

2. Advanced Liposomal Technology

Our proprietary liposomal platform ensures exceptional stability, high drug payload, and targeted delivery of luteolin.

Proprietary Microfluidization Process: High-pressure homogenization (up to 25,000 psi) produces unilamellar liposomes with uniform size distribution (PDI ≤0.2) and maximum encapsulation efficiency, significantly outperforming conventional ethanol injection or thin-film hydration methods. Recent studies confirm that optimized luteolin-loaded liposomal nanoparticles achieve excellent monodispersity and encapsulation performance.

Stabilization Technology: pH 6.0–6.8 buffering system maintains luteolin integrity and prevents degradation during shelf life. Our proprietary cryoprotectant system (trehalose and sucrose-based matrix) prevents liposome aggregation and leakage during lyophilization for powder formats, ensuring >90% encapsulation retention after reconstitution.

Nitrogen-Flushed Packaging: Eliminates oxidative degradation of both luteolin and phospholipids, preserving bioactivity throughout the product lifecycle.

Sustainable & Clean-Label Production: Solvent-free manufacturing (no chloroform, methanol, or dichloromethane). Non-GMO sunflower phospholipids — ideal for vegan and allergen-free labeling. 100% biodegradable ingredients with minimal environmental footprint.

3. Stability & Shelf-Life Superiority

The Scientific Foundation: Why Liposomal Delivery for Luteolin?

Luteolin’s poor aqueous solubility and extensive first-pass metabolism have long been recognized as major barriers to its clinical application. Numerous preclinical studies have confirmed that liposome encapsulation effectively addresses these challenges.

Enhanced Bioavailability: Research demonstrates that luteolin can be efficiently encapsulated into liposomes with encapsulation efficiency as high as 90%, and liposome delivery significantly improves solubility and bioavailability compared to unencapsulated luteolin.

Superior Therapeutic Efficacy: In vivo studies indicate that liposome-encapsulated luteolin achieves superior antitumor effects against colorectal carcinoma compared to luteolin alone. The enhanced delivery enables lower dosing while achieving better clinical outcomes.

Neuroprotective Applications: Post-ischemic administration of liposome-encapsulated luteolin has been shown to prevent against ischemia-reperfusion injury in cerebral artery occlusion models, with the neuroprotective effects attributed to rebalancing of pro-oxidant/antioxidant status.

Anti-Inflammatory Mechanisms: Liposomal luteolin formulations have demonstrated significant anti-inflammatory effects in animal models of atopic dermatitis, evidenced by reduced erythema, edema, and inflammatory cell infiltration. These effects are mediated through suppression of NF-κB and AP-1 activation pathways.

Senolytic Potential: Recent research has focused on developing liposomal and polymeric nanocarriers for luteolin delivery in senolytic therapies, targeting the removal of senescent cells to promote healthy aging.

Pharmacological Profile & Health Benefits

Luteolin is a multifunctional flavonoid with a wide spectrum of biological activities supported by extensive scientific literature. A comprehensive review of recent studies reveals that luteolin exhibits the following key pharmacological properties:

Antioxidant Activity: Luteolin is a potent free radical scavenger, capable of neutralizing superoxide anion radicals, hydroxyl radicals, and other reactive oxygen species. Its antioxidant capacity is attributed to the presence of multiple hydroxyl groups on the flavone backbone, which stabilize free radicals through resonance structures. Studies indicate that luteolin displays stronger antioxidant activity than many related flavonoids.

Anti-Inflammatory Effects: Luteolin exerts powerful anti-inflammatory effects at micromolar concentrations, mediated through multiple pathways including activation of anti-oxidative enzymes, suppression of the NF-κB signaling pathway, and inhibition of pro-inflammatory cytokine production. It has been shown to alleviate NLRP3 inflammasome activation and direct macrophage polarization, further contributing to its immunomodulatory effects.

Neuroprotection: Luteolin demonstrates significant neuroprotective properties, with applications in neurodegenerative conditions and cognitive health. Clinical studies have explored luteolin formulations for improving attention in children with autism spectrum disorders and alleviating brain “fog” in mastocytosis patients. A 12-week, double-blind, placebo-controlled clinical trial is currently investigating the efficacy of luteolin for cognitive impairments in schizophrenia patients.

Anticancer Potential: Luteolin has been extensively studied for its anticancer properties, including induction of apoptosis, inhibition of tumor growth, and chemopreventive effects. PEGylated liposomes carrying luteolin have been shown to effectively induce caspase-3 and caspase-14 protein expression in cancer cell lines, enhancing apoptotic pathways. TPGS-coated liposomes further enhance cellular uptake and apoptosis by upregulating the Bax/Bcl-2 ratio.

Cardiovascular Protection: Luteolin contributes to cardiovascular health through multiple mechanisms, including reduction of oxidized LDL-activated inflammation, inhibition of platelet aggregation, and vasodilation effects.

Metabolic Health: Research indicates that luteolin reduces adipose tissue macrophage inflammation and insulin resistance, with particular relevance to metabolic syndrome and postmenopausal metabolic changes.

Anti-Allergic Properties: Luteolin displays specific anti-allergic activities with a favorable safety profile compared to other flavonoids, making it valuable for immune modulation applications.

Antimicrobial & Antiviral Activity: Luteolin has demonstrated efficacy against various pathogens, with emerging research exploring its potential in COVID-19 related applications.

Clinical Research Highlights

• A Phase I study of men with prostate cancer demonstrated that daily treatment with 50 mg of an oral luteolin supplement is safe and effective with regard to oncological outcomes, particularly in patients under active surveillance.

• A liposomal luteolin formulation in olive fruit extract improved attention in children with autism spectrum disorders and reduced brain “fog” in mastocytosis patients, supporting its role in neurocognitive health.

• Studies on palmitoylethanolamide and luteolin combinations have shown significant improvements in odor discrimination and overall olfactory function in patients with post-infectious olfactory disorders.

• Ongoing clinical trials are investigating luteolin’s efficacy for cognitive impairments in schizophrenia, representing expanding clinical applications for this versatile flavonoid.

Applications & Product Formats

SRBio Liposomal Luteolin is available in multiple formats to suit diverse formulation requirements:

Oral Liquid Supplements: Ready-to-use liquid formulations with enhanced absorption, ideal for direct-to-consumer wellness products.

Softgels & Capsules: Liposomal luteolin encapsulated in softgel or two-piece hard capsules for convenient daily supplementation. Commercial products are available in doses ranging from 450 mg to 500 mg per serving.

Functional Beverages: Stable liposomal dispersions suitable for incorporation into ready-to-drink functional beverages and wellness shots.

Powder for Reconstitution: Lyophilized liposomal luteolin powder that maintains >90% encapsulation efficiency upon reconstitution, ideal for custom formulations and extended shelf-life requirements.

Cosmeceutical Applications: The combination of antioxidant and anti-inflammatory properties makes liposomal luteolin suitable for topical formulations targeting skin health and photoaging protection.

SRBio’s Quality Commitment

cGMP-Compliant Manufacturing: All production processes adhere to current Good Manufacturing Practices, ensuring batch-to-batch consistency and regulatory compliance.

Comprehensive Quality Testing: Each batch undergoes rigorous testing including HPLC purity analysis, encapsulation efficiency verification, particle size characterization by DLS, heavy metals testing by ICP-MS, and microbial limits testing per USP standards.

Full Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), allergen statements, and non-GMO verification available upon request.

Supply Chain Transparency: Direct sourcing of raw materials with full traceability from botanical source to finished liposomal product.

Custom Formulation Support: Technical team available to assist with custom encapsulation parameters, phospholipid selections, and formulation development for specific application requirements.

For inquiries, samples, or technical documentation, please contact our sales team.

SRBio — Advancing Liposomal Delivery for a Healthier Tomorrow

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