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Core Technology: Advanced Liposomal Encapsulation for 10x higher absorption
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Particle Size: Average < 200nm (Ensures superior cell delivery)
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Purity: 98%+ L-Glutathione (Reduced)
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Features: Non-GMO, Soy-Free, Stable in various pH levels
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Support: Full TDS, MSDS, and Stability Test Reports available
Product Parameters & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | L-Glutathione (Reduced Form) |
| CAS Number | 70-18-8 |
| Molecular Formula | C₁₀H₁₇N₃O₆S |
| Molecular Weight | 307.32 g/mol |
| Purity | ≥98% (HPLC) |
| Liposome Encapsulation Efficiency | ≥85% |
| Particle Size (Z-Average) | 100–200 nm |
| Polydispersity Index (PDI) | ≤0.2 |
| Test Methods | HPLC-UV, Dynamic Light Scattering (DLS), TEM |
| Packaging | Nitrogen-flushed glass vials (liquid) / double foil bags (powder), 100g to 25kg options |
| Key Benefits | Potent systemic antioxidant, detoxification support, liver health, immune modulation (up to 400% NK cell enhancement), neuroprotection, skin health/anti-aging, metabolic health, cellular repair |
| Applications | Oral liquid supplements, softgels, capsules, functional beverages, anti-aging and wellness products, cosmeceuticals, sports nutrition |
Unlock the Full Potential of Glutathione with SRBio Liposomal Technology
Glutathione is widely recognized as the body’s “master antioxidant,” a tripeptide composed of glutamate, cysteine, and glycine that is essential for protecting cells from oxidative damage, supporting detoxification pathways, maintaining immune function, and regulating cellular redox balance. However, conventional oral glutathione supplementation faces a fundamental and well-documented challenge: extremely poor oral bioavailability. The molecule undergoes rapid degradation in the gastrointestinal tract, is broken down by proteolytic enzymes before absorption, and exhibits low membrane permeability—rendering standard oral glutathione largely ineffective for elevating systemic levels.
SRBio Liposomal Glutathione solves this bioavailability barrier. Our advanced liposomal encapsulation technology protects glutathione molecules within protective phospholipid bilayers, shielding them from gastric acid and enzymatic degradation, facilitating direct cellular uptake through phospholipid bilayer fusion with enterocytes, and enabling targeted delivery of reduced L-glutathione to cells and tissues throughout the body. Recent clinical and pharmacokinetic studies have confirmed that liposomal formulations significantly improve cellular delivery, biological activity, and systemic bioavailability compared with conventional glutathione, while also protecting active compounds under simulated gastric conditions. Produced under cGMP standards with ≥98% purity and ≥85% encapsulation efficiency, our Liposomal Glutathione unlocks the full therapeutic potential of this essential antioxidant for the anti-aging, detoxification, immune health, and cellular wellness markets.
Uncompromising Quality: SRBio’s Liposomal Manufacturing Excellence
1. Precision Quality Control
| Parameter | SRBio Standard | Competitor Average | Test Method |
|---|---|---|---|
| Glutathione Purity (HPLC) | ≥98.0% | 95.0%–97.0% | HPLC-UV |
| Encapsulation Efficiency | ≥85% | 50%–70% | Size Exclusion Chromatography |
| Particle Size (Z-Average) | 100–200 nm | 200–400 nm | DLS (Malvern) |
| Polydispersity Index (PDI) | ≤0.2 | >0.3 | DLS |
| Phospholipid Source | Non-GMO Sunflower Lecithin | Soy or Synthetic | LC-MS |
| Heavy Metals (Pb, As, Cd) | <0.1 ppm | ≤1.0 ppm | ICP-MS |
| Residual Solvents | Not Detected | ≤500 ppm | GC-FID |
| pH (Dispersion) | 5.5–6.5 | 3.5–5.0 | pH Meter |
| Microbial Limits | Conforms to USP <61> | Variable | Plate Count |
2. Advanced Liposomal Technology
Our proprietary liposomal platform is specifically optimized for glutathione’s unique physicochemical properties, ensuring high payload, exceptional stability, and enhanced absorption.
Proprietary Microfluidization Process: High-pressure homogenization (up to 25,000 psi) produces unilamellar liposomes with uniform size distribution (PDI ≤0.2) and maximum encapsulation efficiency, outperforming conventional ethanol injection or thin-film hydration methods. Modern liposomal manufacturing technologies, including microfluidics and high-pressure homogenization, offer improved precision, scalability, and environmental sustainability.
Stabilization Technology: pH-Optimized Buffering maintains the formulation at pH 5.5–6.5, preserving glutathione integrity—particularly its reduced state—and preventing oxidation or degradation. Our proprietary cryoprotectant system (trehalose and sucrose-based matrix) prevents liposome aggregation and leakage during lyophilization for powder formats, ensuring >90% encapsulation retention after reconstitution. Glutathione formulations typically require controlled pH environments to maintain the active reduced form and prevent conversion to oxidized glutathione (GSSG).
Nitrogen-Flushed Packaging: Eliminates oxidative degradation, preserving both glutathione and phospholipids throughout the product lifecycle. Liposomal glutathione is known to be highly stable under GMP storage conditions, with powder formulations offering extended shelf life compared to liquid formats.
Sustainable & Clean-Label Production: Solvent-free manufacturing (no chloroform, methanol, or dichloromethane). Non-GMO sunflower phospholipids—ideal for vegan and allergen-free labeling. 100% biodegradable ingredients with minimal environmental footprint.
3. Stability & Shelf-Life Superiority
| Parameter | SRBio Liposomal Glutathione | Conventional Glutathione (Powder) |
|---|---|---|
| Stability (25°C / 60% RH) | ≥95% potency at 24 months | Rapid oxidation; potency declines significantly |
| Gastric pH Resistance | Protected; <10% degradation in simulated gastric fluid (2h) | >70% degradation within 60 minutes |
| Reduced Form Retention | >95% remains as reduced GSH | Significant conversion to GSSG |
| Storage | Powder: ambient / Liquid: cool, dry conditions | Requires cool, dark, dry storage |
| Reconstitution Stability (powder) | ≥90% encapsulation retention | Not applicable |
The Scientific Foundation: Why Liposomal Delivery for Glutathione?
Glutathione’s clinical utility as an oral supplement has long been limited by its poor bioavailability. The molecule is a tripeptide susceptible to enzymatic breakdown by gamma-glutamyl transpeptidase and other peptidases in the gastrointestinal tract, and it exhibits low passive diffusion across intestinal epithelial membranes. The use of nanomaterials and liposomes is recognized as an effective method for improving the therapeutic effects of glutathione.
Enhanced Bioavailability: A human pharmacokinetic study demonstrated that oral liposomal glutathione administration significantly elevates glutathione levels in whole blood and various intra- and extracellular compartments. Research has shown that liposomal glutathione is absorbed in substantially higher amounts compared to non-encapsulated glutathione, which is absorbed in low amounts. One formulation has been reported to achieve up to 64-fold higher plasma levels compared to traditional glutathione supplements.
Cellular Delivery & Uptake: The phospholipid bilayer of liposomes closely resembles cell membranes, allowing liposomes to pass through the intestinal wall and deliver encapsulated glutathione directly into the bloodstream. This mechanism dramatically boosts intracellular uptake—explaining the significantly higher bioavailability of liposomal glutathione seen in clinical studies. In vitro cellular models and in vivo human pharmacokinetic evaluations have confirmed that liposomal glutathione significantly improves cellular delivery, biological activity, and systemic availability compared with conventional glutathione.
Immune Function Enhancement: A 1-month pilot clinical study of oral liposomal glutathione administration in healthy adults at doses of 500 mg and 1000 mg per day demonstrated that daily liposomal GSH administration effectively elevates stores of GSH and impacts immune function. Natural killer (NK) cell cytotoxicity was elevated by up to 400% within two weeks (P<0.05), representing a dramatic enhancement of innate immune surveillance. In HIV-infected individuals, 13 weeks of liposomal GSH supplementation restored TH1 cytokine response, significantly increasing levels of IL-1β, IL-12, IFN-γ, and TNF-α.
Detoxification & Liver Health: A 30-day pilot clinical study of liposomal glutathione supplementation (750 mg twice daily) demonstrated a significant reduction in bilirubin and a 39% decrease in blood mercury levels, indicating enhanced detoxification and improved liver function. Liposomal glutathione shows particular promise for fatty liver disease (both alcoholic and nonalcoholic) by supporting liver detoxification pathways, protecting liver cells from oxidative damage, and reducing inflammation. Supplementation with liposomal glutathione has been associated with a 30–35% increase in blood glutathione levels in healthy adults over a 6-month period.
Oxidative Stress Reduction: A growing body of clinical evidence demonstrates that liposomal glutathione supplementation effectively reduces systemic oxidative stress. A targeted metabolomic assessment confirmed that liposomal glutathione improves cellular delivery and systemic bioavailability compared to conventional oral formulations. Studies have shown significant reductions in oxidative stress markers across multiple conditions.
Neuroprotection: Liposomal glutathione has demonstrated neuroprotective potential in research models. A liposomal preparation of glutathione was investigated for its ability to replenish intracellular GSH and provide neuroprotection in an in vitro model of Parkinson’s disease, with findings indicating that glutathione supplied in a liposomal formulation holds promise as a potential therapeutic for neuronal maintenance. Glutathione depletion is associated with neurological deficits, cognitive issues, Parkinson’s disease, and autism.
Skin Health & Anti-Aging: Oxidative stress accelerates cellular aging by inducing telomere shortening. Liposomal glutathione’s superior intracellular delivery supports cellular antioxidant defenses and promotes healthy aging. A 12-week independent clinical trial produced statistically significant evidence that liposomal glutathione measurably reduces skin redness and improves hyperpigmentation across the entire face. Lower doses (250–500 mg) are effective for skin health maintenance, while higher doses (500–1000 mg) show faster effects in clinical studies focused on reducing hyperpigmentation.
Safety Profile: Liposomal glutathione is well-tolerated in clinical use. No serious adverse events have been reported in any human trial at doses up to 1500 mg/day for 3 months.
Pharmacological Profile & Health Benefits
Glutathione (GSH) is a tripeptide thiol that serves as the most abundant endogenous antioxidant in human cells. Its biological functions extend far beyond free radical scavenging, encompassing roles in detoxification, immune regulation, cellular redox homeostasis, protein function modulation, and mitochondrial integrity maintenance.
Master Antioxidant Defense: GSH is the body’s primary water-soluble antioxidant, directly neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS). It also serves as a cofactor for antioxidant enzymes including glutathione peroxidase (GPx) and glutathione-S-transferase (GST). Through its ability to recycle other antioxidants such as vitamins C and E, GSH maintains systemic antioxidant capacity. Liposomal glutathione has been shown to be up to 100 times more effective at replenishing intracellular glutathione levels compared to non-liposomal glutathione in research models.
Detoxification: Glutathione is essential for Phase II detoxification in the liver, where it conjugates with xenobiotics, heavy metals, and other toxins to enhance their water solubility and facilitate excretion. Liposomal glutathione has demonstrated efficacy in heavy metal detoxification, with clinical studies showing significant reductions in mercury levels following supplementation.
Immune System Modulation: GSH plays a critical role in lymphocyte function, T-cell proliferation, and NK cell activity. Clinical studies have demonstrated that liposomal glutathione supplementation significantly enhances NK cell cytotoxicity and restores TH1 cytokine responses in immunocompromised individuals. Liposomal glutathione is also being investigated as adjunctive therapy in viral infection contexts.
Liver Health & Hepatoprotection: The liver contains the highest concentration of glutathione in the body. Liposomal glutathione supports liver detoxification pathways, protects hepatocytes from oxidative damage, reduces inflammation in fatty liver disease, and improves liver function markers. Studies have shown improved liver health markers in individuals with nonalcoholic fatty liver disease (NAFLD) and other liver conditions.
Neuroprotection & Cognitive Health: Low intracellular glutathione levels are associated with neurological deficits, cognitive decline, and neurodegenerative conditions including Parkinson’s disease and Alzheimer’s disease. Liposomal glutathione has shown neuroprotective effects in preclinical models of Parkinson’s disease, suggesting potential for supporting neuronal health and cognitive function.
Skin Health & Anti-Aging: Glutathione is widely recognized for its skin health benefits, including reduction of hyperpigmentation, improved skin tone and radiance, and protection against photoaging. Clinical studies have demonstrated measurable improvements in skin redness and hyperpigmentation following liposomal glutathione supplementation.
Sports Performance & Recovery: Intense exercise decreases blood glutathione levels and generates oxidative stress. Liposomal glutathione supports athletic performance, recovery, and endurance by reducing oxidative fatigue and aiding muscle recovery. Glutathione also supports mitochondrial function, which is essential for sustained energy production.
Metabolic Health & Cellular Repair: Glutathione plays a role in maintaining metabolic balance, supporting cell repair mechanisms, and promoting healthy aging. Research has shown that glutathione plays a key role in reducing oxidative stress, supporting normal immune function, aiding cell repair, and contributing to metabolic balance.
Clinical Research Highlights
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A 1-month pilot clinical study of oral liposomal glutathione in healthy adults (500 mg and 1000 mg daily) demonstrated effective elevation of GSH stores in whole blood and multiple cellular compartments, with NK cell cytotoxicity elevated by up to 400% within two weeks.
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A 30-day clinical study of liposomal glutathione (750 mg twice daily) showed a 39% reduction in blood mercury levels and decreased bilirubin, indicating enhanced detoxification and improved liver function.
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A 12-week independent clinical trial produced statistically significant evidence that liposomal glutathione reduces skin redness and improves hyperpigmentation across the entire face.
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A 13-week study in HIV-infected individuals demonstrated that liposomal GSH supplementation restored TH1 cytokine response, significantly increasing levels of IL-1β, IL-12, IFN-γ, and TNF-α.
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Pharmacokinetic evaluations have confirmed that liposomal glutathione significantly improves cellular delivery, biological activity, and systemic bioavailability compared with conventional glutathione.
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A randomized crossover clinical trial evaluating oral glutathione bioavailability and safety in humans compared liposomal glutathione with standard formulations.
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Ongoing clinical research is investigating liposomal glutathione for oxidative stress correction, immune support in healthy adults, and applications in neurodegenerative diseases.
Applications & Product Formats
SRBio Liposomal Glutathione is available in multiple formats to suit diverse formulation requirements:
Oral Liquid Supplements: Ready-to-use liquid formulations with enhanced absorption, ideal for direct-to-consumer wellness products. Available in shelf-stable formats with convenient dosing mechanisms.
Softgels & Capsules: Liposomal glutathione encapsulated in softgel or two-piece hard capsules for convenient daily supplementation. Formulations are available in doses ranging from 250 mg to 1000 mg per serving, supporting both maintenance and therapeutic applications.
Functional Beverages: Stable liposomal dispersions suitable for incorporation into ready-to-drink functional beverages, wellness shots, and powdered drink mixes. The mild organoleptic profile of liposomal glutathione allows for clean formulation without strong sulfur taste.
Powder for Reconstitution: Lyophilized liposomal glutathione powder that maintains ≥90% encapsulation efficiency upon reconstitution, ideal for custom formulations, extended shelf-life requirements, and applications requiring concentrated dosing. Powder formats typically offer 24-month shelf life at room temperature versus 6–12 months for liquids.
Cosmeceutical Applications: Liposomal glutathione is increasingly used in topical formulations targeting skin health, hyperpigmentation, anti-aging, and antioxidant protection. Liposome encapsulation enhances skin penetration and delivery of glutathione to deeper epidermal layers.
Sports Nutrition: Liposomal glutathione can be incorporated into pre-workout formulas, recovery blends, and performance nutrition products targeting oxidative stress reduction and muscle recovery enhancement.
SRBio’s Quality Commitment
cGMP-Compliant Manufacturing: All production processes adhere to current Good Manufacturing Practices, ensuring batch-to-batch consistency and regulatory compliance. GMP certification plays a critical role in determining the real performance of liposomal supplements, influencing structural integrity, stability, and nutrient delivery.
Comprehensive Quality Testing: Each batch undergoes rigorous testing including HPLC purity analysis, encapsulation efficiency verification, particle size characterization by DLS, heavy metals testing by ICP-MS, and microbial limits testing per USP standards.
Full Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), allergen statements, non-GMO verification, and vegan certification documentation available upon request.
Supply Chain Transparency: Direct sourcing of high-purity reduced L-glutathione with full traceability from raw material to finished liposomal product.
Custom Formulation Support: Technical team available to assist with custom encapsulation parameters, phospholipid selections, glutathione concentration adjustments, and formulation development for specific application requirements.
Ordering Information
| Product Format | Packaging Options | Minimum Order Quantity |
|---|---|---|
| Liposomal Glutathione Powder (Lyophilized) | 100g, 500g, 1kg, 5kg, 25kg | 100g |
| Custom Formulations | Variable | Contact for details |
All products are shipped in temperature-controlled packaging with full chain-of-custody documentation. Custom labeling, private labeling, and contract manufacturing services are available upon request. OEM/ODM services support full customization from dosage strength to excipient selection.
For inquiries, samples, or technical documentation, please contact our sales team.
