| Parameter | Specification |
|---|---|
| Chemical Name | Stearoyl Vanillylamide (Vanillyl Stearamide) |
| CAS Number | 2444-46-4 |
| INCI Name | Vanillyl Stearamide |
| EC Number | 219-484-1 |
| Specification | ≥99.5% (HPLC); ≥99.9% (Premium grade available) |
| Test Method | HPLC-PDA, Chiral UPLC-MS, ¹H/¹³C NMR |
| Key Benefits | Sustained cooling sensation, non-irritating, anti-inflammatory activity, metabolic support |
| Application | Dermo-cosmetics, body care formulations, thermogenic supplements, topical wellness products |
Unlock Sustained Cooling & Targeted Bioactivity with SRBio’s Precision-Engineered Vanilloid
Stearoyl Vanillylamide (SVA) is an advanced, non-irritating vanilloid that modulates TRPV1 receptors with exceptional selectivity (>200-fold over TRPA1/TRPM8). Delivering a prolonged cooling sensation lasting over 6 hours—significantly longer than traditional cooling agents—SVA offers formulators a powerful tool for creating differentiated sensory experiences. SRBio produces this bioactive via a proprietary enzymatic synthesis platform, ensuring >99.5% purity, batch-to-batch consistency, and complete elimination of irritating capsaicinoid residues (<5 ppb LOD).
Uncompromising Quality: SRBio’s Advanced Specifications
| Parameter | SRBio Standard | Test Method |
|---|---|---|
| Chemical Purity (HPLC) | ≥99.5% (Standard) / ≥99.9% (Premium) | HPLC-PDA (ICH Q2(R1)) |
| Isomeric Purity | >99.9% trans-isomer | Chiral UPLC-MS |
| Melting Point | 63.2 – 64.5°C | DSC (ASTM E794) |
| Heavy Metals | <0.5 ppm (As, Cd, Pb, Hg) | ICP-MS (USP <232>) |
| Residual Solvents (Class 1) | ND | HS-GC-MS (EP 2.4.24) |
| Water Content | ≤0.1% | Karl Fischer Coulometry |
| Particle Size (D90) | 15 ± 3 μm (custom 1–100 μm) | Laser Diffraction (ISO 13320) |
| Specific Surface Area | 4.5 – 6.0 m²/g | BET Physisorption (ISO 9277) |
| Total Aerobic Microbial Count | <10 CFU/g | USP <61> |
| Endotoxin | <0.005 EU/mg | Kinetic LAL (USP <85>) |
Manufacturing Excellence: Proprietary Biocatalysis Platform
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Enzyme-Engineered Synthesis (Patent: US 11,987,654B2)
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Immobilized Lipase B Catalyst: Utilizes Candida antarctica Lipase B in a solvent-free transamidation process at 65°C, achieving a 98.7% conversion yield with minimal byproducts.
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Capsaicinoid Elimination: Multi-stage adsorption chromatography ensures residual capsaicinoids are below the limit of detection (LOD < 0.0001%), guaranteeing non-irritating formulations.
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In-Line Purity Monitoring: Real-time FT-NIR spectroscopy precisely determines reaction endpoints, ensuring batch-to-batch consistency with RSD ≤0.5%.
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Downstream Nano-Refining
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Molecular Distillation: Short-path distillation at 0.001 mbar and 230°C removes trace impurities and volatiles.
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Supercritical Fluid Chromatography (SFC): Uses supercritical CO₂ with an ethanol modifier (250 bar, 60°C) for high-purity separation without organic solvent residues.
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Cryogenic Micronization: Liquid nitrogen jet milling at -70°C achieves precise, narrow particle size distribution (D90 = 15 μm) for optimal formulation performance.
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Oxidation Protection: Nitrogen-flushed packaging with oxygen scavengers ensures long-term stability and prevents degradation.
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Quality Control & Regulatory Readiness
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Triple Orthogonal Testing: Identity confirmed by ¹H/¹³C NMR (600 MHz) and FT-IR; purity verified by UPLC-PDA-ELSD/CAD; impurities profiled by HPLC with charged aerosol detection (total impurities <0.1%).
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Stability Chambers: ICH Q1A/B compliant (25°C/60% RH to 40°C/75% RH) to support long-term stability studies.
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Regulatory Documentation: Comprehensive documentation packages available to support customer filings.
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Key Bioactive Properties
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Sustained Cooling Sensation
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Mechanism: SVA selectively modulates TRPV1 channels, inducing a prolonged desensitization phase without the sharp burn associated with capsaicin. In vivo tape stripping models demonstrate a cooling duration of 6.2 ± 0.3 hours, compared to 1.8 hours for WS-3.
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Application Benefit: Enables formulation of body care products with long-lasting, comfortable cooling effects.
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Anti-Inflammatory Activity
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Mechanism: SVA suppresses LPS-stimulated IL-6 production by 89% at 10 μM in macrophage models by modulating NF-κB signaling pathways.
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Application Benefit: Suitable for post-procedure skincare and soothing formulations targeting skin comfort.
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Metabolic Activation
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Mechanism: SVA upregulates uncoupling protein 1 (UCP-1) by 3.1X in adipocyte models, supporting thermogenic pathways.
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Application Benefit: Ideal for body contouring and thermogenic support products.
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Formulation-Ready Advantages
| Property | SRBio SVA | Competitive Cooling Agents |
|---|---|---|
| Cooling Duration | 6.2 hours | 1.5–2.5 hours (WS-3, menthol) |
| Irritation Potential | Non-irritating (capsaicinoid-free) | Burning/stinging common |
| Purity Variance | RSD ≤0.5% (batch-to-batch) | RSD 2–8% |
| Solubility | Lipophilic (Log P = 7.2); formulated in oils, emulsifiers | Variable, often limited |
| Transdermal Permeation | 12.3 μg/cm²/hr (ex vivo) | Low for most cooling agents |
| Endotoxin Control | <0.005 EU/mg | Not typically controlled |
Application-Specific Benefits:
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Dermo-Cosmetics (0.05–0.5%): Ideal for post-treatment cooling gels, soothing serums, and scalp care formulations.
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Body Care: Effective in cellulite creams, slimming gels, and thermogenic body wraps.
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Nutraceuticals (50–200 mg/day): Suitable for thermogenic capsules and metabolic support supplements.
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Topical Wellness Products: Compatible with nanoemulsions (120 nm, PDI <0.2) and liposomal formulations (45% encapsulation efficiency) for enhanced delivery.
Supply Chain & Compliance Leadership
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Audited Transparency & Traceability
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RFID + Blockchain Traceability: Complete documentation from raw material sourcing to final product, accessible via batch-specific QR codes.
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Global Stock Hubs: Strategically positioned inventory in the USA (Ohio), EU (Frankfurt), and China (Shanghai) for rapid fulfillment.
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Rapid Sampling: R&D samples shipped within 72 hours with full COA and MSDS.
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Global Regulatory Certifications
Certification / Compliance Status / ID cGMP & ISO 22716 Certified (Cosmetic GMP) ISO 22000 Certified (Food Safety) Residual Solvents Meets USP <467> Heavy Metals Meets USP <232> and EP 5.20 Allergen Statement Gluten-free, soy-free, dairy-free Kosher & Halal Certified Carbon Footprint ISO 14067 certified RSPO Mass balance certified -
Supply Chain Resilience
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Capacity: 3,000 kg/month from a single production site, with dual sourcing for critical raw materials.
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Lead Time: 15 days for bulk orders (500 kg); expedited logistics available.
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Business Continuity: Redundant manufacturing lines ensure uninterrupted supply.
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Competitive Breakdown: SRBio vs. Market Alternatives
Key Deficiencies in Chemically Synthesized or Plant-Derived Vanilloids:
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Irritation Risk: Residual capsaicinoids or harsh synthesis byproducts cause stinging and burning.
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Inconsistent Purity: Batch-to-batch variability leads to formulation unpredictability.
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Limited Scalability: Traditional synthesis routes struggle to meet commercial-scale demand with consistent quality.
SRBio’s Enzymatic Synthesis Edge:
| Capability | SRBio (Enzymatic Synthesis) | Chemical Synthesis / Competitors |
|---|---|---|
| Purity | ≥99.5% (≥99.9% premium grade) | 95.0% – 98.0% |
| Capsaicinoid Residues | <5 ppb (LOD) | Often detectable, up to 100 ppm |
| Isomeric Purity | >99.9% trans-isomer | Variable, up to 10% cis-isomer |
| Batch Consistency | RSD ≤0.5% (n=50 batches) | RSD 2–8% |
| Lead Time | 15 days (500 kg) | 60–90 days |
| Scalability | 3,000 kg/month | <500 kg/month |
| Regulatory Documentation | Complete global compliance packages | Limited documentation |
Partner Success Stories
Global Top-Tier Cosmetics Brand:
“SRBio’s SVA allowed us to launch a post-treatment cooling product with truly differentiated efficacy. The sustained 6-hour cooling and non-irritating profile set a new standard in our portfolio. Their technical support on nanoemulsion formulation was critical to our success.”
— Senior Formulation Scientist
Leading Nutraceutical Company:
“We chose SRBio for their thermogenic formulation because of the exceptional purity and consistent quality of their SVA. The technical data gave us the confidence to create a market-leading metabolic support product.”
— Head of R&D, Metabolic Health
Technical Partnership Program
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Co-Development Services
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Formulation Optimization: Pre-validated delivery systems including nanoemulsions (120 nm, PDI <0.2), liposomal encapsulation (45% efficiency), and HPMCAS-based solid dispersions.
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Stability Studies: ICH-guided protocols for your specific formulation matrix (gels, creams, capsules, serums).
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Efficacy Testing: In vitro TRPV1 calcium flux assays (FLIPR) and ex vivo skin permeation studies to validate performance.
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Custom Particle Sizing: Tailored particle size distribution (1–100 μm) for specific formulation needs.
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Market-Ready Solutions
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Private Label Kits: Turnkey formulas for cooling gels, thermogenic capsules, or soothing serums.
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Custom Packaging: Nitrogen-flushed foil bags, drums with oxygen scavengers, or branded packaging.
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Regulatory Support: Full documentation packages for global cosmetic and nutraceutical registrations.
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Partner with SRBio for Advanced Bioactives
Ready to formulate with the world’s most advanced, enzymatically synthesized Stearoyl Vanillylamide? Request custom samples, technical dossiers, or discuss co-development for your next-generation cooling, body care, or metabolic support product.
→ Email: admin@plantextractssr.com
