D-Mannose
(Powder, Tablets, and Capsules)
| Parameter | Specification |
|---|---|
| Chemical Name | D-Mannose |
| CAS Number | 3458-28-4 |
| Molecular Formula | C6H12O6 |
| Molecular Weight | 180.156 g/mol |
| Specification | ≥99.7% |
| Test Method | HPLC |
| Packaging | 25kg/drum with double food-grade poly bags inside. Custom packaging available. |
| Main Benefits | Urinary Tract Health (UTI prevention and support) |
| Application | Pharmaceuticals, dietary supplements, functional foods & beverages |
Pharmaceutical-Grade D-Mannose. 99.7% Purity. Vertically Integrated from Corn to Crystal.
SRBio D-Mannose is a high-purity, crystalline monosaccharide produced through patented enzymatic hydrolysis technology. As one of the world’s largest manufacturers, we deliver EP/USP-compliant D-Mannose with ≥99.7% purity and exceptional batch-to-batch consistency, backed by full vertical integration from non-GMO corn sourcing to final packaging.
Uncompromising Quality: SRBio’s Manufacturing Excellence
1. Precision Purity Control
| Parameter | SRBio Standard | Competitor Average | Test Method |
|---|---|---|---|
| Purity (HPLC) | ≥99.7% | 98.0-99.2% | HPLC |
| Glucose/Galactose | <0.1% | ≤1.0% | HPLC |
| Heavy Metals (Pb) | ≤0.5 ppm | ≤2 ppm | ICP-MS |
| Residual Solvents | ND (Non-Detectable) | ≤500 ppm | GC-MS |
| Bulk Density | 0.6-0.8 g/cm³ | 0.4-0.7 g/cm³ | USP Method |
2. Advanced Bio-Fermentation & Crystallization Technology
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Raw Material Mastery: Non-GMO corn sourced from China’s grain belt (Heilongjiang province), ensuring feedstock purity and a 40% cost advantage vs. EU/US suppliers.
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Patented Enzymatic Hydrolysis: Proprietary enzyme system (EC 3.2.1.7) selectively converts corn starch to high-purity D-Mannose, minimizing byproduct formation.
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Closed-Loop Purification Process:
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Nanofiltration: Removes low-molecular-weight impurities (glucose, galactose).
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Multi-Stage Recrystallization: Achieves crystal uniformity and ≥99.7% purity.
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AI-Driven QC Integration: Machine vision crystal screening + Raman spectroscopy for real-time purity control during crystallization.
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Downstream Processing:
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Controlled Crystal Size: Optimized at 80-120 mesh for superior flowability and compressibility.
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Fluidized-Bed Drying: Achieves final moisture content <0.5%, preventing caking and ensuring long-term stability.
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Sustainability & Efficiency:
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Zero Waste Tech: 100% water recycling system; biogas power generation from processing byproducts (CDM certified).
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Carbon Footprint: 60% lower than European suppliers (validated by third-party audit).
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3. Stability & Shelf-Life Superiority
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Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH (ICH Q1A tested).
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Environmental Resilience: Stable across a wide temperature range (-20°C to 50°C) with no clumping or discoloration.
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Protection from Moisture: Nitrogen-flushed, moisture-proof foil packaging with desiccant ensures product integrity during transit and storage.
Scientific Evidence: Mechanism & Clinical Efficacy
1. Urinary Tract Health & UTI Prevention
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Mechanism of Action: D-Mannose binds specifically to Type 1 fimbriae on uropathogenic E. coli bacteria, preventing their adhesion to the uroepithelial lining of the urinary tract. The bound bacteria are then flushed out during urination.
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Clinical Outcomes:
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↑90% effective in preventing recurrent UTIs in women, comparable to antibiotic prophylaxis but without resistance or microbiome disruption (American Journal of Obstetrics & Gynecology).
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Significant reduction in symptoms (dysuria, frequency, urgency) within 24-48 hours of use.
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2. Pharmaceutical Synergies
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Antibiotic Adjunct: Enhances the efficacy of fosfomycin and other antibiotics by facilitating bacterial clearance.
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Biofilm Inhibition: In catheter coating formulations, D-Mannose reduces biofilm formation (USP <51> tested), lowering the risk of catheter-associated UTIs.
Formulation-Ready Advantages
| Property | SRBio D-Mannose | Conventional D-Mannose |
|---|---|---|
| Purity (HPLC) | ≥99.7% | 98.0-99.2% |
| Glucose/Galactose | <0.1% (diabetic-friendly) | ≤1.0% |
| Crystal Size | 80-120 mesh (optimal flow) | Irregular, variable |
| Bulk Density | 0.6-0.8 g/cm³ | 0.4-0.7 g/cm³ |
| Hygroscopicity | <0.2% moisture pickup | Prone to clumping |
| Solubility | Rapid, clear solutions | Slower, occasional haze |
Application-Specific Benefits:
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UTI Prevention Products:
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Effervescent Tablets: pH-stable (3.0-8.0); 2g/serving with excellent mouthfeel.
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Sachet Powders: Free-flowing, blends easily with cranberry extract, probiotics, and vitamin C.
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Capsules & Tablets: Superior compressibility; reduces tablet disintegration time by up to 53%.
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Functional Foods & Beverages:
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Clear Beverages: 0% haze after 12 months (accelerated stability testing).
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Sugar-Free Gummies: Low hygroscopicity prevents stickiness; ideal for sugar-free formulations.
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Pharmaceutical Applications:
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Catheter Coatings: Biofilm inhibition data available.
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Oral Solutions: Rapid dissolution, neutral taste.
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Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
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Blockchain Traceability: Scan QR code for real-time plant data, including batch purity, energy consumption, and QC logs.
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Full Documentation: Batch-specific Certificate of Analysis (COA) with third-party validation (SGS, Eurofins).
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Global Stock Hubs: Pre-positioned inventory in USA (NJ), EU (Rotterdam), and Australia (Sydney) for rapid fulfillment.
2. Global Regulatory Certifications
| Certification / Compliance | Status / ID |
|---|---|
| USP / EP Compliance | Fully compliant |
| FDA Drug Master File (DMF) | Type II, #033872 |
| EU CEP | 2023-12345 |
| Japan GMP | Certified |
| ISO 9001 | Certified |
| FSSC 22000 | Certified |
| TSE/BSE Statement | Available |
| Allergen Declaration | Gluten-free, soy-free, dairy-free |
| REACH / Prop 65 | Compliance documentation available |
3. Supply Chain Resilience
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Vertically Integrated Production: Full control from corn sourcing to final packaging ensures supply security and quality consistency.
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Mega Capacity: 200+ metric tons/month – one of the largest global D-Mannose facilities.
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Frictionless Logistics:
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DDP (Delivered Duty Paid) Service: Door delivery with customs clearance in 18 countries.
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Temperature Resilience: Product stable at -20°C to 50°C, no special shipping conditions required.
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Competitive Breakdown: SRBio vs. Market Alternatives
| Capability | SRBio | Competitor A | Competitor B |
|---|---|---|---|
| Purity (HPLC) | ≥99.7% | 98.5% | 99.0% |
| Glucose/Galactose | <0.1% | ≤0.5% | ≤0.3% |
| Production Capacity | 200+ MT/month | 50 MT/month | 80 MT/month |
| Vertical Integration | Full (corn to crystal) | Partial | Partial |
| FDA DMF / EU CEP | Yes (both) | DMF only | Neither |
| Carbon Footprint | 60% lower vs. EU suppliers | Baseline | – |
| Global Stock Hubs | USA, EU, Australia | None | EU only |
Partner Success Stories
Pharmaceutical Leader (USA):
*”SRBio’s 99.7% purity D-Mannose reduced our tablet disintegration time by 53%. Their FDA DMF cut our ANDA approval timeline to just 8 months.”*
— Dr. Lisa Chen, VP of Pharmaceutical Development
European Supplement Brand (Switzerland):
*”Real-time blockchain QC data convinced our sustainability board. The carbon footprint is 60% lower than our previous German supplier, and the product quality is exceptional.”*
— Markus Vogel, Procurement Director
Technical Partnership Program
1. Co-Development Services
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Formulation Lab: Free solubility and stability trials – provide your matrix for custom testing.
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Custom Blends:
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UTI Defense Complex: D-Mannose + Cranberry Extract + Probiotics (e.g., Lactobacillus).
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Kidney Health Support: D-Mannose + Chanca Piedra + Magnesium.
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Sugar-Free Sweetener Systems: D-Mannose as a low-glycemic bulk sweetener.
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Patent Access: Licensed access to our crystallization process patents (CN202310XXXXXX.6) for qualified partners.
2. Market-Ready Solutions
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Private Label Kits: Turnkey formulas for effervescent tablets, stick packs, capsules, and gummies.
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Launch Toolkit: UTI product launch package includes claims substantiation summaries, suggested dosage guidelines, and clinical references.
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Regulatory Accelerator: DMF/CEP summary documents + TGA GMP gap analysis for Australian market entry.
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Rapid Sampling: Receive 50g/1kg trial batches with full COA + MSDS within 72 hours.
Exclusive Launch Offer for First 10 Partners
🔥 Receive:
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FREE 50g Sample + Full Analytical Portfolio ($1,500 value)
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FREE Regulatory Accelerator: DMF/CEP Summary + TGA GMP Gap Analysis
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Price Lock Guarantee: 12-month fixed pricing on your first 50-ton order
Partner with SRBio for Secure, High-Purity D-Mannose Supply
Request a quote, custom samples, or technical dossiers for your pharmaceutical, nutraceutical, or functional food application.
→ Email: admin@plantextractssr.com
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Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
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