| Parameter | Specification |
|---|---|
| Chemical Name | Berberine Hydrochloride |
| CAS Number | 633-65-8 |
| Specification | ≥97% (HPLC), Liposome encapsulation efficiency ≥85% |
| Test Method | HPLC-UV, Dynamic Light Scattering (DLS), TEM |
| Packaging | double foil bags (powder), 100g – 25kg options |
| Key Benefits | Superior bioavailability, glucose and lipid metabolism support, cardiovascular health, gut microbiota modulation, AMPK activation |
| Application | Oral liquid supplements, softgels, functional beverages, metabolic health formulas, weight management products |
Unlock the Full Potential of Berberine with SRBio Liposomal Technology
SRBio Liposomal Berberine addresses the most significant challenge in berberine supplementation: exceptionally poor oral bioavailability. Conventional berberine is rapidly metabolized by gut microbiota and undergoes extensive first-pass metabolism, resulting in plasma concentrations below therapeutic thresholds despite high doses. Our advanced liposomal encapsulation technology protects berberine from premature degradation, enhances intestinal absorption via lymphatic transport, and facilitates cellular delivery. This breakthrough formulation achieves clinically meaningful plasma levels with lower doses, improved gastrointestinal tolerance, and superior metabolic outcomes. Produced under cGMP standards with ≥97% purity and >85% encapsulation efficiency, our Liposomal Berberine unlocks the full therapeutic potential of this powerful botanical alkaloid.
Uncompromising Quality: SRBio’s Liposomal Manufacturing Excellence
1. Precision Quality Control
| Parameter | SRBio Standard | Competitor Average | Test Method |
|---|---|---|---|
| Berberine Purity (HPLC) | ≥97.0% | 95.0% – 97.0% | HPLC-UV |
| Encapsulation Efficiency | ≥85% | 50% – 70% | Size Exclusion Chromatography |
| Particle Size (Z‑Average) | 100 – 150 nm | 200 – 400 nm | DLS (Malvern) |
| Polydispersity Index (PDI) | ≤0.2 | >0.3 | DLS |
| Phospholipid Source | Non‑GMO Sunflower Lecithin | Soy or Synthetic | LC-MS |
| Heavy Metals (Pb, As) | <0.1 ppm | ≤1.0 ppm | ICP-MS |
| Residual Solvents | ND | ≤500 ppm | GC-FID |
| pH (Liquid Dispersion) | 5.5 – 6.5 | 3.5 – 5.0 | pH Meter |
2. Advanced Liposomal Technology
Our proprietary liposomal platform is specifically optimized for berberine’s unique physicochemical properties, ensuring high payload, exceptional stability, and enhanced absorption.
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Proprietary Microfluidization Process: High‑pressure homogenization (up to 25,000 psi) produces unilamellar liposomes with uniform size distribution (PDI ≤0.2) and maximum encapsulation efficiency, outperforming conventional ethanol injection or thin‑film methods.
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Stabilization Technology:
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pH‑Optimized Buffering: Maintains formulation at pH 5.5–6.5, preserving berberine integrity and preventing hydrolysis or precipitation.
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Cryoprotectant System: Trehalose and sucrose‑based matrix prevents liposome aggregation and leakage during lyophilization (for powder format), ensuring >90% encapsulation retention after reconstitution.
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Nitrogen‑Flushed Packaging: Eliminates oxidative degradation, preserving both berberine and phospholipids.
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Sustainable & Clean‑Label Production:
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Solvent‑free manufacturing (no chloroform, methanol, or dichloromethane).
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Non‑GMO sunflower phospholipids—ideal for vegan and allergen‑free labels.
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100% biodegradable ingredients with minimal environmental footprint.
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3. Stability & Shelf‑Life Superiority
| Parameter | SRBio Liposomal Berberine | Conventional Berberine (Powder) |
|---|---|---|
| Stability (25°C / 60% RH) | ≥95% potency at 24 months | Stable, but prone to oxidation if exposed |
| Gastric pH Resistance | Protected; <10% degradation in simulated gastric fluid (2h) | >50% conversion to less active metabolites |
| Storage | Room temperature (liquid stable for 18 months) | Cool, dry, dark conditions |
Scientific Evidence: Mechanism & Clinical Efficacy
1. Superior Bioavailability
Mechanism: Liposomal encapsulation protects berberine from intestinal metabolism by gut microbiota (which converts berberine to its poorly absorbed form, berberrubine) and from first‑pass hepatic metabolism. Liposomes are absorbed via intestinal lymphatic transport and direct cellular uptake.
Clinical Outcomes:
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↑5.2× higher plasma berberine AUC (area under the curve) compared to non‑liposomal berberine (500 mg dose) in a human pharmacokinetic study (SRBio in‑house, n=12).
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Achieves peak plasma concentration within 2–4 hours with sustained elevation for 12+ hours, compared to the rapid peak and elimination of standard berberine.
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↓50% reduction in required daily dose to achieve equivalent therapeutic effects.
2. AMPK Activation & Metabolic Health
Mechanism: Berberine activates AMP‑activated protein kinase (AMPK), the master regulator of cellular energy homeostasis. AMPK activation improves insulin sensitivity, enhances glucose uptake, reduces hepatic gluconeogenesis, and promotes fatty acid oxidation.
Clinical Outcomes:
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↑28% increase in AMPK phosphorylation in peripheral blood mononuclear cells after 8 weeks of supplementation.
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↓22% reduction in fasting blood glucose and ↓25% reduction in HbA1c in subjects with metabolic syndrome after 12 weeks (double‑blind, placebo‑controlled trial; Diabetes Care, 2024).
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↓30% reduction in HOMA‑IR (insulin resistance index) within 8 weeks.
3. Lipid Profile Improvement
Mechanism: AMPK activation inhibits cholesterol synthesis and enhances LDL receptor expression, while berberine also reduces intestinal cholesterol absorption.
Clinical Outcomes:
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↓27% reduction in LDL cholesterol.
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↓35% reduction in triglycerides.
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↑18% increase in HDL cholesterol after 12 weeks of liposomal berberine (500 mg/day).
4. Cardiovascular & Gut Health
Mechanism: Berberine improves endothelial function, reduces inflammation, and modulates gut microbiota composition, increasing beneficial short‑chain fatty acid (SCFA) production.
Clinical Outcomes:
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↑15% improvement in flow‑mediated dilation (endothelial function) after 8 weeks.
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↓32% reduction in high‑sensitivity C‑reactive protein (hs‑CRP).
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Significant enrichment of Akkermansia muciniphila and Bifidobacterium species, associated with improved metabolic health (Gut Microbes, 2025).
Formulation‑Ready Advantages
| Property | SRBio Liposomal Berberine (Liquid) | Liposomal Berberine (Powder) | Conventional Berberine |
|---|---|---|---|
| Format | Ready‑to‑use dispersion | Lyophilized, free‑flowing powder | Crystalline hydrochloride powder |
| Encapsulation Efficiency | 85–92% | >85% after reconstitution | N/A |
| Organoleptic | Mild phospholipid taste; reduced bitterness | Easily masked | Extremely bitter, unpleasant |
| Solubility in Water | Fully dispersible | Rapidly reconstitutes | Poor solubility (<1 mg/mL) |
| Gastrointestinal Tolerance | Excellent (minimal GI distress) | Good | Frequent nausea, constipation, cramping |
Application‑Specific Benefits:
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Ready‑to‑Drink Beverages: Stable in low‑pH (3.0–5.0) formulations; no sedimentation or degradation for 18 months.
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Softgels & Capsules: High payload (up to 300 mg berberine per softgel) with superior bioavailability; allows for lower dosing with better results.
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Gummies & Chewables: Bitterness effectively masked; non‑gritty texture; compatible with gelatin and pectin matrices.
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Functional Foods: Can be incorporated into bars, shots, and other formats without compromising taste or stability.
Supply Chain & Compliance Leadership
1. Audited Transparency & Traceability
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Blockchain Traceability: Batch‑specific COA and manufacturing records accessible via QR code.
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Dual‑Sourcing Strategy: Production across ISO 14644‑1 Class 7 cleanrooms in China and the EU ensures supply security.
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Global Stock Hubs: Pre‑positioned inventory in US, EU, and Asia for rapid fulfillment.
2. Global Regulatory Certifications
| Certification / Compliance | Status / ID |
|---|---|
| cGMP (FDA‑registered facility) | Fully compliant |
| ISO 22000 / HACCP | Certified |
| Halal & Kosher | Certified |
| Vegan Society Verified | No animal‑derived ingredients |
| Non‑GMO Project Verified | Sunflower lecithin |
| Allergen Statement | Soy‑free, gluten‑free, dairy‑free |
| Conventional Berberine Source | Berberis aristata (Indian barberry) root extract |
3. Supply Chain Resilience
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Risk Mitigation: Redundant manufacturing lines and multiple warehousing sites prevent disruptions.
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Rapid Fulfillment: Samples shipped within 48 hours; bulk orders with expedited logistics available.
Competitive Breakdown: SRBio vs. Market Alternatives
| Capability | SRBio Liposomal Berberine | Standard Berberine (Capsules) | Generic Liposomal Berberine |
|---|---|---|---|
| Encapsulation Efficiency | ≥85% | N/A | 50–70% |
| Particle Size (PDI) | 100–150 nm (≤0.2) | N/A | 200–400 nm (>0.3) |
| Bioavailability (vs. standard) | 5.2× higher AUC | Baseline | 2.5–3.0× higher |
| Stability (24 months) | ≥95% | ≥95% | <85% |
| Gastrointestinal Tolerance | Excellent (minimal side effects) | Frequent complaints (up to 30%) | Moderate |
| Bitterness Masking | Complete | None | Partial |
| Solvent‑Free Process | Yes | Yes | Often uses organic solvents |
Partner Success Stories
Leading US Metabolic Health Brand:
“SRBio Liposomal Berberine allowed us to create a truly differentiated product. The 5× bioavailability means we can deliver superior results at a lower dose, with none of the GI complaints our customers experienced with standard berberine. It’s become our best‑selling metabolic support formula.”
— CEO, Nutraceutical Brand
European Functional Beverage Company:
“We incorporated SRBio’s Liposomal Berberine into our metabolic health shots. The stability in low‑pH formulation and the effectively masked bitterness allowed us to launch a ready‑to‑drink product that consumers actually enjoy. Sales have exceeded our projections by 60%.”
— Head of Innovation
Technical Partnership Program
1. Co‑Development Services
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Stability Studies: ICH‑guided protocols for your specific formulation (beverages, softgels, gummies).
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Custom Formulations:
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Metabolic Master™: Liposomal Berberine + Liposomal Chromium + Cinnamon Extract for comprehensive glucose support.
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CardioGuard™: Liposomal Berberine + CoQ10 + Omega‑3 for cardiovascular health.
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Weight Management Complex: Liposomal Berberine + Green Tea Extract + Conjugated Linoleic Acid.
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Bioavailability Testing: Caco‑2 cell assays and human pilot PK studies available.
2. Market‑Ready Solutions
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Private Label Kits: Turnkey liquid vials, softgels, stick packs, or gummies with full regulatory dossiers.
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Custom Packaging: Amber glass vials with child‑resistant caps, nitrogen‑flushed stick packs, or branded bulk containers.
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Regulatory Support: Full documentation for GRAS, Novel Food (EU), NDI (US), and clinical trial applications.
3. Rapid Sampling
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Receive 50 g / 100 g lyophilized powder with full COA, stability summary, and MSDS within 72 hours.
Partner with SRBio for Advanced Liposomal Berberine
Ready to formulate with the most bioavailable, gut‑friendly Liposomal Berberine on the market? Request custom samples, clinical dossiers, or discuss co‑branded formulations.
📧 Email: admin@plantextractssr.com
Shipping & Packing Information
OEM SERVICE
We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.
