PQQ (pyrroloquinoline quinone)
(Powder, Tablets and Capsules)
| Chemical Name: | pyrroloquinoline quinone |
| CAS Number: | 72909-34-3 |
| Specification: | 98% |
| Test Method: | HPLC |
| Packaging: | In paper-drums and two layers of poly bags inside. Net weight: 25kg/drum |
| Main Benefits: | Enhances short-term memory and attention, improves energy metabolism |
| Application: | dietary supplements |
Unlock Cellular Vitality with Premium PQQ (Pyrroloquinoline Quinone) by SRBio
SRBio PQQ: A tricyclic aromatic quinone compound essential for cellular energy, growth, and anti-aging. Naturally sourced and scientifically validated to enhance mitochondrial health, cognitive function, and antioxidant defense. The human body cannot synthesize PQQ—optimal levels depend on external supplementation.
Uncompromising Quality: SRBio’s Manufacturing Excellence
1. Precision Purity Control
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HPLC-UV/MS Dual Verification: Purity consistently ≥99.8% (tested per USP/EP monographs).
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Heavy Metal Screening: ICP-MS validated limits: Arsenic (<0.1 ppm), Lead (<0.05 ppm), Mercury (ND).
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Residual Solvents: GC-FID tested; complies with ICH Q3C guidelines (Class 1 solvents undetectable).
2. Advanced Fermentation Technology
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Proprietary Strain: Hyphomicrobium dentirificans SRB-01 (Patent No. CN114456999B) – Engineered for high-yield PQQ biosynthesis (12 g/L productivity).
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Closed-Batch Fermentation: Prevents cross-contamination; real-time metabolite monitoring via bioreactor sensors.
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Downstream Processing:
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3-step ceramic membrane filtration (0.1 μm cutoff).
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Low-temperature vacuum crystallization (<40°C) preserves molecular integrity.
Eco-Impact: 78% lower carbon footprint vs. chemical synthesis (ISO 14067 certified).
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3. Stability & Shelf-Life Superiority
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Accelerated Stability Data: Retains ≥98% potency after 24 months at 25°C/60% RH (ICH Q1A tested).
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Light/Oxygen Protection: Nitrogen-flushed foil packaging with desiccant canisters.
Scientific Evidence: Mechanism & Efficacy
1. Mitochondrial Biogenesis
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Upregulates PGC-1α: Activates AMPK/SIRT1 pathway (Cell Metab. 2020; 32(4): 575–591).
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Human Trial Results: 20 mg/day × 12 weeks → 27% increase in mitochondrial density (measured via citrate synthase activity).
2. Neurocognitive Benefits
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BDNF Modulation: Increases brain-derived neurotrophic factor by 40% in hippocampal neurons (J. Alzheimers Dis. 2023).
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Clinical Outcomes:
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14% improvement in Rey Auditory Verbal Learning Test (RAVLT).
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22% faster Trail Making Test B completion (Front. Aging Neurosci. 2022).
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3. Antioxidant Redox Cycling
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Catalyzes >20,000 redox cycles without degradation (vs. 4 cycles for vitamin C).
Formulation-Ready Advantages
| Property | SRBio PQQ | Competitor Average |
|---|---|---|
| Solubility (H₂O) | 50 mg/mL (pH 6.5–7.5) | <5 mg/mL |
| Bulk Density | 0.45 g/cm³ | 0.68 g/cm³ |
| Particle Size | D90 ≤ 50 μm (laser diffraction) | D90 ≥ 150 μm |
| pH Stability | 2.0–9.0 (24-h test) | Degrades at pH >7.5 |
Application-Specific Benefits:
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Gummies/Chewables: Zero grit texture; compatible with gelatin/pectin matrices.
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RTD Beverages: No sedimentation after 6 months (accelerated testing).
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Tableting: Direct compression compatible; ejection force ≤5 kN.
Supply Chain & Compliance Leadership
1. Audited Transparency
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Blockchain Traceability: Batch-specific COA accessible via QR code (includes strain genealogy & fermentation logs).
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Dual-Sourcing Strategy: Production across ISO 22000-certified sites (China + EU).
2. Regulatory Preparedness
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Global Dossiers: Full GRAS, Novel Food (EU), and FSSAI documentation support.
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Allergen Statement: Validated free from gluten, soy, dairy, crustaceans (ELISA tested).
3. Ethical Certifications
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Vegan Society Verified: No animal-derived inputs in fermentation media.
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Ecovadis Silver Rating: Recognized for ethical labor practices & waste recycling (96% rate).
Competitive Breakdown: SRBio vs. Market Alternatives
Key Deficiencies in Chemical-Synthesized PQQ:
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Pyrrole Impurities: N-methylpyrrole (≤3%) in synthesis routes → genotoxicity concerns (Ames test positive).
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Crystallization Issues: Polymorphic instability → batch failure in humid climates.
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Solvent Residues: Acetonitrile/ethyl acetate traces (≤500 ppm) requiring post-treatment.
SRBio’s Fermentation Edge:
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0% Organic Solvents: Water-based extraction only.
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Polymorph Control: Exclusive Patent CN113527265A guarantees stable β-crystal form.
Technical Partnership Program
1. Co-Development Services
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Stability Studies: ICH-guided protocols for your formulation matrix (e.g., PQQ + Mg²⁺ compatibility).
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Bioavailability Testing: Caco-2 cell assays or rodent pharmacokinetics (Tmax <45 mins).
2. Market-Ready Solutions
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Custom Blends:
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NeuroCharge™: PQQ + Cognizin® Citicoline (synergistic acetylcholine boost).
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MitoComplex®: PQQ + Microencapsulated R-Lipoic Acid (targeted mitochondrial delivery).
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Private Label Kits: Turnkey formulas for capsules (500 mg), effervescent tablets, or nasal sprays.
Receive 50g/500g trial batches with COA + MSDS within 72h
Video & Articles
Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
