What is Dihydromyricetin
Hovenia dulcis is a Traditional Chinese Medicine for hangovers that is distributed naturally in the areas surrounding China, Japan, Korea, and the Himalayas.
The molecule we know as Dihydromyricetin is also called Ampelopsin, and is extracted using an ethanol-based solution from the fruit of the Hovenia Dulcis tree, and minimally processed before it’s dehydrated and turned into a powder ready to be purified.
How does Dihydromyricetin work
The unpleasant feelings that stem from a hangover are generally attributed to a combination of factors including dehydration, fatigue, glucose imbalances, as well as toxic impurities found in some alcoholic beverages (i.e. congeners) – but above all due to the toxic byproduct of alcohol metabolism, acetaldehyde.
Two enzymes help your body break down alcohol (ethanol) and acetaldehyde (‘ethanal’) — alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). A number of studies (Chen et al., 2006) suggest that dihydromyricetin – one of the main ingredients in Survivor – increases the activity of said enzymes, meaning DHM could help you metabolize alcohol faster.
Additionally, another recent study found that people who ingested DHM experienced less headache, dizziness, nausea, and weakness after drinking than those who did not take the DHM (Kim et al., 2017). This article discusses DHM and hangovers and how the latter affects the former.
DHM, also known as Dihydromyricetin or Ampelopsin, is a potent flavonoid. It has been seen to help accelerate your body’s ability to break down acetaldehyde, the toxic by-product of alcohol metabolisation.
Fairly new in the eyes of Western science, it has been used for thousands of years in traditional Chinese medicine – the plants from which DHM can be extracted, Ampelopsis grossedentata and Hovenia dulcis, have have been used as remedies or a supplement for hangovers for centuries and consumed as teas, powder preparations, and infusions.
DHM has recently invited considerable academic interest given its promise of an entire swathe of health-beneficial effects. DHM studies suggest Dihydromyricetin (DHM) relieves alcohol toxicity and prevents intoxication by limiting the absorption of alcohol in the gastrointestinal tract and promoting the metabolisation of alcohol in the liver. DHM has even been proposed as a ‘novel anti-intoxication medication’ (Shen et al., 2012).
Indeed, DHM ‘has been demonstrated to show anti-oxidative, anti-inflammatory, anticancer, antimicrobial, cell death-mediating, and lipid and glucose metabolism-regulatory activities’ (Li et al., 2017). There are now over 279 studies across medical publisher databases PubMed and Google Scholar, and many more in the pipeline. Definitely the flavonoid to keep your eye on!
Why Choose SRBio DHM Powder
1.SRBIO’s Unmatchable Value Matrix
| Advantage | Evidence-Based Proof | Competitor Gap |
|---|---|---|
| Purity Mastery | HPLC-ELSD dual verification: 99.2% avg. (Batch SR2301-789) | Industry avg: 92-95% |
| Supply Chain Control | Own 200-hectare organic tea farms (QTPP-certified) in Fujian | 87% rely on uncertified wild harvest |
| Extraction Yield | 12:1 concentration ratio via subcritical H₂O/CO₂ hybrid tech | Standard: 20-25:1 |
| Regulatory Readiness | Pre-audited DMF (Drug Master File) for FDA NDIs & EFSA Novel Food | 2-3 year documentation la |
2. Hyper-Detailed Production Workflow
Stage 1: Sourcing with Genomics
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Raw Material: Ampelopsis grossedentata from GPS-tagged plots (Soil pH 5.2-6.0)
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Authentication: DNA barcoding (ITS2 + psbA-trnH markers), reject if <98% match
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Pre-treatment: Infrared drying (45°C) to reduce water activity <0.3
Stage 2: Advanced Extraction
Yield Booster: Dynamic MAC (Mixed Adsorbent Column) traps flavonoids
Stage 3: Pharmaceutical Purification
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Prep-HPLC: Waters Alliance System, C18 column (250×50mm), gradient: 25%→60% MeOH/H₂O
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Impurity Removal: Targeted elimination of dihydroquercetin (RT 8.3min)
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Crystallization: Ethyl acetate/hexane recrystallization (3 cycles)
Stage 4: Particle Engineering
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Lyophilization: -45°C/0.01mbar → moisture <1%
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Micronization: Jet mill to D90 <15μm (enhanced dissolution)
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Stabilization: N₂-flushed trilayer foil bags with oxygen scavengers
4. Quality Control: Laboratory Warfare
Tiered Testing Protocol
| Phase | Tests Performed | Equipment | Acceptance Criteria |
|---|---|---|---|
| Raw Material | Pesticides (198 items), Aflatoxins, Cadmium | GC-MS/MS, LC-QTOF | EU MRLs compliant |
| In-Process | DHM/DHQ ratio, Residual solvents | UPLC-PDA, Headspace GC | DHQ <0.5%, EtOH <500ppm |
| Release | Purity (HPLC-ELSD), Heavy metals, Microbiology | ICP-MS, USP <61> | Pb<0.5ppm, TAMC<100 CFU/g |
| Stability | ICH Q1A(R2): 40°C/75% RH for 24 months | Forced degradation chamber | Purity retention >98% at 24M |
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Xi’an SR Bio-Engineering Co., Ltd
Xi’an SRBio is a professional wholesale provider of many quality nutritional supplements products and AMINO ACID Powde etc.
We supply powder, tablets and capsules.
When you take dihydromyricetin really depends on what you’re trying to accomplish. So, for example, researchers found that taking a relatively large dose before drinking it reduced the circulating levels of alcohol in the blood. For most people however,….read more
What You May Need?
Note: SRBio Anti-Hangover Formula is not just a fly by night formulation, it has been worked now for over a year, by a well respected researcher in Switzerland, a food scientist from the Sunshine Coast, Australia and a product Developer from Sydney, Australia. The primary ingredients contained in it has been scientifically studied, and generates results in the real world.
So what exactly comprises the nuts and bolts behind SRBio Anti-Hangover Formula?
- Hovenia Dulcis (Japanese Raisin berry tree)
- Milk Thistle Extract
- Cactus Pear Extract
- Korean Pear Extract
- Panax Ginseng Extract
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