Next-Generation Liver Health & Hangover Relief: SRBio High-Purity DHM

(China Organic Farm Direct · 99.2% Purity · Pharmaceutical-Grade Process)

SRBio’s Dihydromyricetin (DHM) is more than a simple flavonoid extract. It is a genomics-traced, pharmaceutical-grade active ingredient. By integrating our 200-hectare certified organic tea farms (QTPP-certified) in Fujian with our patented subcritical water/CO₂ hybrid extraction technology, we deliver DHM powder with an average purity of 99.2%—far exceeding the 92-95% industry average—providing global brands with a scientifically validated solution for alcohol metabolism support and liver protection.

Uncompromising Quality: SRBio’s Manufacturing Excellence

1. Genomics Sourcing & Vertically Integrated Supply Chain

   • Own Organic Farms: We control quality at the source with 200 hectares of QTPP-certified organic farms in Fujian for Ampelopsis grossedentata (Vine Tea). Soil pH is strictly maintained at 5.2-6.0 to optimize natural flavonoid accumulation.

   • DNA Barcoding Authentication: Every raw material batch is authenticated via DNA barcoding (ITS2 + psbA-trnH markers). Batches with <98% genetic match are rejected.

   • Infrared Low-Temperature Drying: Raw material is dried at 45°C using infrared technology, reducing water activity to <0.3 and preserving maximum natural bioactivity.

2. Patented Extraction & Pharmaceutical-Grade Purification

   • Subcritical Water/CO₂ Hybrid Technology: Our patented hybrid technology achieves a highly concentrated 12:1 ratio, efficiently enriching target flavonoids far beyond the standard 20-25:1 range.

   • Dynamic MAC (Mixed Adsorbent Column) Technology: During extraction, MAC technology is used to specifically capture and enrich DHM, significantly boosting extraction efficiency.

   • Preparative HPLC Purification: Final purification is performed using a Waters Preparative HPLC System (C18 column, 250×50mm, methanol/water gradient) to target and remove key impurities like Dihydroquercetin (DHQ) , ensuring DHQ <0.5%.

   • Triple Recrystallization: Three cycles of recrystallization (ethyl acetate/hexane) achieve pharmaceutical-grade purity standards.

3. Particle Engineering & Long-Term Stability

   • Micronization: Processed with a jet mill to achieve particle size D90 < 15 microns, significantly improving dissolution rate and bioavailability.

   • Lyophilization (Freeze-Drying): Performed at -45°C/0.01mbar to control moisture to <1%, ensuring excellent stability.

   • Protective Packaging: Packaged in trilayer foil bags, nitrogen-flushed with integrated oxygen scavengers, guaranteeing >98% purity retention after 24 months under ICH Q1A(R2) accelerated stability testing (40°C/75% RH).

Scientific Evidence: Mechanism & Clinical Research

1. Accelerated Alcohol Metabolism & Hangover Relief

   • Mechanism: DHM is a potent activator of the key enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). It accelerates the conversion of ethanol to acetaldehyde and then to harmless acetate, reducing peak blood alcohol and toxic acetaldehyde levels.

   • Clinical Data:

     • Alcohol Clearance: Studies show DHM significantly lowers blood alcohol concentration and shortens intoxication time (Shen et al., 2012).

     • Symptom Improvement: A clinical trial found that individuals taking DHM experienced significantly less headache, dizziness, nausea, and weakness after alcohol consumption (Kim et al., 2017).

2. Liver Protection & Metabolic Regulation

   • Mechanism: Through its potent antioxidant activity, DHM reduces alcohol-induced oxidative stress and inflammation in the liver. It also modulates lipid and glucose metabolic pathways.

   • Research Review: Over 279 studies on PubMed and Google Scholar confirm DHM’s antioxidant, anti-inflammatory, anticancer, antimicrobial, cell death-regulating, and lipid/glucose metabolism-regulating activities (Li et al., 2017).

Technical Specifications: SRBio vs. Market Alternatives

Formulation & Application Solutions

1. Hangover Relief & Liver Health

   • Core Application: Used in capsules, tablets, or liquid shots taken before or after alcohol consumption to accelerate metabolism, protect the liver, and reduce next-day discomfort.

   • SRBio Anti-Hangover Complex Formula: We offer a scientifically designed synergistic formula including:

     • Core: DHM (High-Purity)

     • Synergistic Ingredients: Hovenia dulcis Extract, Milk Thistle Extract, Cactus Pear Extract, Korean Pear Extract, Panax Ginseng Extract. This multi-target formula accelerates alcohol breakdown, neutralizes free radicals, and replenishes key nutrients.

2. Functional Sobriety Beverages

   • Clear RTD Beverages: Our micronized DHM with enhanced solubility allows for the development of clear, portable functional shots or drinks to be consumed during or after drinking.

3. Sports Recovery & Metabolic Health

   • Sports Nutrition: DHM’s antioxidant and anti-inflammatory properties make it ideal for post-exercise recovery formulas, helping to reduce exercise-induced oxidative stress.

   • Metabolic Support: Based on its activity in regulating glucose and lipid metabolism, DHM can also be used in supplements supporting healthy blood sugar and lipid levels.

Quality Control: Four-Tiered Testing Protocol

Supply Chain & Compliance Leadership

1. Comprehensive Regulatory Readiness

   • Pre-Audited Dossiers: We provide key documentation for your global registrations, including:

     • USA (FDA): Drug Master File (DMF) for New Dietary Ingredient (NDI) applications.

     • EU (EFSA): Novel Food application dossier.

   • Complete Analytical Reports: Each batch ships with a detailed Certificate of Analysis (COA) including purity, impurity profile, heavy metals, pesticides, and microbiology.

2. Ethical & Sustainable Sourcing

   • Organic Certified: Raw material is sourced from our QTPP-certified organic farms, ensuring pesticide-free and sustainable cultivation.

   • Fully Traceable: GPS-tagged cultivation plots provide a complete chain of custody from soil to finished product.

Technical Partnership Program

1. Co-Development Services

   • Formulation Support: Our R&D team can assist in incorporating DHM into complex matrices, such as liquid beverages, softgels, or synergistic herbal blends.

   • Stability Studies: ICH-guided stability testing for your specific formulation matrix.

2. Market-Ready Solutions

   • Custom Blends: We can provide customized pre-mixes containing DHM tailored to your target market, such as our professionally developed SRBio Anti-Hangover Complex Formula.

   • Rapid Sampling: Trial batches (1kg) available for shipment within 72 hours, with full COA.

📦 Partner with the Neuro-Nutrition Leader

Request samples, clinical dossiers, or discuss co-development today.

• 📞 English Support: +86-13720408392

• 📧 Email: admin@plantextractssr.com

SRBio Dihydromyricetin (DHM): Pharmaceutical-Grade Purity for a New Era of Liver Health.

Video & Articles

What You May Need?

Note: SRBio Anti-Hangover Formula is not just a fly by night formulation, it has been worked now for over a year, by a well respected researcher in Switzerland, a food scientist from the Sunshine Coast, Australia and a product Developer from Sydney, Australia. The primary ingredients contained in it has been scientifically studied, and generates results in the real world.
So what exactly comprises the nuts and bolts behind SRBio Anti-Hangover Formula?

• Hovenia Dulcis (Japanese Raisin berry tree)
• Milk Thistle Extract
• Cactus Pear Extract
• Korean Pear Extract
• Panax Ginseng Extract

Shipping & Packing Information

OEM SERVICE

We offer all-inclusive product development from consultation to delivery.
We make product proposals based on the customer’s requirements, from small to large lots.

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