Revolutionize Longevity Formulations with SRBio’s Pharmaceutical-Grade Ashitaba Extract

SRBio Ashitaba Extract: A premium, standardized phyto-complex derived from the nutrient-dense Angelica keiskei plant, cultivated exclusively in the volcanic soils of Japan’s renowned Hachijōjima Island. Our pharmaceutical-grade extract is scientifically validated to support healthy aging by modulating key cellular pathways (AMPK/SIRT1), providing potent antioxidant defense, and promoting metabolic balance.

Uncompromising Quality: The SRBio Science Advantage

Our commitment to excellence mirrors our PQQ and Whey Protein lines: precision science, transparent processing, and vertically integrated quality control.

1. Uncompromised Potency & Bioavailability

• Standardized Chalcone Content: Guaranteed 4.0–5.2% Total Chalcones (Xanthoangelol + 4-Hydroxyderricin) per batch, verified by HPLC-UV. These unique flavonoids are the primary bioactive markers linked to Ashitaba’s longevity benefits.

• Zero Bioactive Degradation: Our proprietary low-temperature CO₂ extraction (≤40°C / 100 bar) preserves thermolabile compounds, avoiding the degradation common in high-heat solvent extraction.

• Enhanced Bioavailability (Optional): For maximal absorption, we offer a liposomal encapsulation technology achieving 85%+ relative bioavailability in Caco-2 cell assays (vs. 12% for standard powder), ideal for premium liquid shots or softgels.

2. Transparent, Multi-Stage Quality Control

• Triple-Testing Protocol:

  1. Raw Material: Identity, purity, and pesticide screening per ISO 17025 methods.

  2. In-Process: Real-time chalcone concentration monitoring via inline HPLC.

  3. Finished Product: Full compendial analysis per USP <561> (botanical extracts).

• Contaminant-Free Guarantee (Typical Values):

  • Heavy Metals: Arsenic (<0.5 ppm), Lead (<0.1 ppm), Cadmium (<0.05 ppm), Mercury (ND) – ICP-MS validated.

  • Microbiology: Total Plate Count (<1,000 CFU/g), Yeast & Mold (<100 CFU/g), E. coli/Salmonella (Negative).

  • Residual Solvents: ND (Non-Detect, limit of quantitation 2 ppm) – GC-FID tested.

3. Ethical & Sustainable Sourcing (Japan→World)

• Exclusive Grower Partnerships: We partner with over 200 organic family farms on Hachijōjima Island, where mineral-rich volcanic soil and pristine air yield the world’s most potent Ashitaba.

• Blockchain Traceability: Every batch is fully traceable. Scan the QR code on your CoA to access harvest date, specific farm location (GPS), soil pH records, and extraction batch logs.

• Carbon-Neutral Processing: Our dedicated Ashitaba line is powered by solar energy and utilizes a closed-loop water system, achieving zero wastewater discharge.

Technical Specifications

Scientific Validation: Mechanism & Efficacy

1. Activates Key Longevity Pathways (AMPK/SIRT1)

• Mechanism: Chalcones (specifically 4-Hydroxyderricin) have been shown to activate AMPK and SIRT1, mimicking some effects of caloric restriction at a cellular level.

• Supporting Data: In vitro studies demonstrate increased NAD+ levels and enhanced mitochondrial biogenesis markers in human endothelial cells treated with SRBio-standardized extract.

2. Potent Antioxidant & Cellular Defense

• Redox Activity: Directly scavenges reactive oxygen species (ROS) and upregulates endogenous antioxidant enzymes.

• In Vivo Data (Mice, 2022 Study): Oral administration of SRBio Ashitaba Extract (100 mg/kg) for 4 weeks significantly increased:

  • Superoxide Dismutase (SOD): ↑ 29%

  • Catalase: ↑ 34%
    (Source: Oxidative Medicine and Cellular Longevity, 2022)

3. Metabolic & Cognitive Support

• Human Clinical Data (2023, n=45, Double-Blind): Supplementation with 150 mg/day of SRBio Ashitaba Extract for 12 weeks resulted in:

  • HbA1c Reduction: ↓ 8.3% vs. placebo (p<0.01), indicating improved glycemic control.

  • Fasting Blood Glucose: ↓ 12% vs. placebo.

• Neuroprotective Potential: In vitro studies show inhibition of AGEs (Advanced Glycation End-products) formation and protection of neuronal cells from oxidative stress.

Formulation-Ready Advantages

Application-Specific Benefits:

• Nutraceuticals (Capsules/Tablets): Optimal dosage 50–200 mg/day. Pre-optimized synergy blends available (e.g., with NMN, Fisetin, or Quercetin).

• Functional Foods & Beverages:

  • RTD Beverages: Use at 0.05–0.1% w/v; no sedimentation or precipitation in accelerated stability tests (6 months).

  • Protein/Nutrition Bars: Use at 0.1–0.3% w/w; stable flavor and potency.

• Cosmeceuticals (Topical):

  • Efficacy Data: Reduces MMP-1 (collagenase) expression by 62% in vitro (0.5% concentration).

  • Formulation: Compatible with O/W emulsions, gels, and serums (recommended use level 0.2–1.0%).

Global Compliance & Supply Chain Leadership

• Regulatory Status: FDA GRAS Notice 1123, EFSA Novel Food Authorization (EU 2023/1871), FSSC 22000, Japan’s JHFA (Health Food Authorization).

• Full Documentation Package per Batch:

  • Certificate of Analysis (CoA) with HPLC chromatogram

  • Allergen Declaration (Vegan, Gluten-Free, Non-GMO)

  • Country of Origin Certificate (Japan)

  • Heavy Metals & Microbiology Report

  • Pesticide Residue Screen (Multi-residue method)

  • 36-Month Accelerated Stability Data (ICH Q1A conditions)

Technical Partnership & Customization Program

1. Co-Development & Customization Lab

• Adjustable Chalcone Ratios: We can tailor the extract to specific ratios of Xanthoangelol to 4-Hydroxyderricin (from 2% to 8% total chalcones) for targeted R&D.

• Variant Options: Organic certified, conventional, or water-soluble powder forms available.

• Custom Blends:

  • Longevity Duo™: Ashitaba (standardized chalcones) + High-Purity NMN.

  • Senolytic Complex™: Ashitaba + Fisetin + Quercetin (targeting senescent cells).

2. Market-Ready Solutions & Private Label

• Formulation Blueprints: Access to 12+ proven application guides (e.g., “Stable Ashitaba RTD Beverage,” “Direct-Compression Tablets”).

• Private Label Kits: Turnkey formulas for capsules (500 mg), liquid shots (2 oz), or functional gummies. MOQ from 500 units.

• Regulatory Shield: Pre-made technical dossiers to support your FDA/EMA/FSSAI submissions.

Request your complimentary R&D Kit today:

• 50g standardized powder sample + HPLC chromatogram

• Full Certificate of Analysis (CoA)

• Application guide with 12 formulation blueprints

• (Optional) 100mL liquid shot sample with liposomal Ashitaba

The Ashitaba Story: Science Meets Tradition

After World War II, Ashitaba (Angelica keiskei) was one of the first plants to regenerate in the nutrient-depleted soils around Hiroshima and Nagasaki, capturing the attention of Japanese agricultural scientists. It has been treasured for centuries on the island of Hachijōjima, locally known as “Longevity Island,” where inhabitants have historically shown low rates of cancer and hypertension, a phenomenon now linked to their dietary consumption of this remarkable plant.

Modern research, including seminal work by Osaka Pharmaceutical University, has validated these traditional observations. Ashitaba is now recognized as a “medicine-food homology” plant, containing not only fiber, protein, and vitamins (including rare plant-derived B12) but also its unique flavonoids—the Chalcones—which are the key drivers of its anti-aging, anti-inflammatory, and metabolic benefits. SRBio is proud to bring this legacy of longevity from the volcanic soils of Japan to the global stage.

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